Simultaneous quantification of 9-(β-d-1,3-dioxolan-4-yl)guanine, Amdoxovir and Zidovudine in human plasma by liquid chromatography-tandem mass spectrometric assay

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 29, 2009, Pages 3482-3488

  Fromentin, Emilie ^a   Asif, Ghazia ^a   Obikhod, Aleksandr ^a   Hurwitz, Selwyn J ^a   Schinazi, Raymond F ^a  

^a Center for AIDS Research   (United States)

Author keywords

Nucleoside analogs; Pharmacokinetics

Indexed keywords

ANALYTES; ANTIVIRAL NUCLEOSIDE; FUNCTIONAL SENSITIVITIES; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; HUMAN PLASMAS; LINEAR CALIBRATION; LOWER LIMIT OF QUANTIFICATIONS; MASS-TO-CHARGE RATIO; MATRIX; NUCLEOSIDE ANALOGS; PLASMA SAMPLES; PROTEIN PRECIPITATION; RUNTIMES; SENSITIVE METHOD; SIMULTANEOUS MEASUREMENT; TANDEM MASS SPECTROMETRIC;

BIOMOLECULES; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; METHANOL; PHARMACOKINETICS; PLASMA (HUMAN); POSITIVE IONS; ULTRAFILTRATION;

ELECTROSPRAY IONIZATION;

9 (BETA DEXTRO 1,3 DIOXOLAN 4 YL)GUANINE; AMDOXOVIR; ANTIRETROVIRUS AGENT; ANTIVIRUS AGENT; DRUG METABOLITE; NUCLEOSIDE ANALOG; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; ZIDOVUDINE;

ARTICLE; BLOOD SAMPLING; CHEMICAL STRUCTURE; DEAMINATION; DRUG BLOOD LEVEL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; PLASMA; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ANTIVIRAL AGENTS; CHROMATOGRAPHY, LIQUID; DIOXOLANES; GUANINE; HUMANS; PURINE NUCLEOSIDES; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; ZIDOVUDINE;

EID: 72149120028     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.08.030     Document Type: Article

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