Mild and efficient ligand-free copper-catalyzed condensation for the synthesis of quinazolines

Tetrahedron Letters

Volumn 51, Issue 4, 2010, Pages 758-760

  Truong, Vouy Linh ^a   Morrow, Michelle ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 IODOBENZALDEHYDE; AMIDINE; BENZAMIDINE; COPPER; FUNCTIONAL GROUP; LIGAND; METHANOL; QUINAZOLINE DERIVATIVE; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; ARYLATION; CATALYSIS; CHEMICAL REACTION; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; POLYMERIZATION; SUBSTITUTION REACTION; ULLMANN REACTION;

EID: 72149116698     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.11.133     Document Type: Article

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27. 14 The mixture was filtered through a Celite cartridge and the cartridge was washed three times with EtOAc. The filtrate was concentrated in vacuo, and the crude product was purified by flash chromatography on silica gel using ethyl acetate-hexanes (0:100-30:70) to afford 3a in 89% yield (158 mg).
28. 4, filtered, and concentrated in vacuo.