Caspase-4 activation in association with decreased adenosine deaminase activity may be a factor for gastric ulcer

Digestion

Volumn 81, Issue 1, 2010, Pages 62-67

  Yaguchi, Takahiro ^a   Saito, Masaru ^a   Yasuda, Yoshiyuki ^a   Nishizaki, Tomoyuki ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Adenosine deaminase; Apoptosis; Caspase 4; Stomach; Ulcer

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 9 (2 HYDROXY 3 NONYL)ADENINE; ADENOSINE DEAMINASE; ADENOSINE DEAMINASE INHIBITOR; CASPASE 3; CASPASE 4;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NICK END LABELING; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; RISK FACTOR; STOMACH BIOPSY; STOMACH CANCER; STOMACH EPITHELIUM; STOMACH ULCER; WESTERN BLOTTING;

ADENINE; ADENOSINE; ADENOSINE DEAMINASE; ADULT; AGED; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES, INITIATOR; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; GASTRIC MUCOSA; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; OSMOLAR CONCENTRATION; RATS; STOMACH; STOMACH ULCER;

EID: 72149107872     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000252771     Document Type: Article

References (9)

1. Blackburn MR, Datta SK, Kellems RE: Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency. J Biol Chem 1998; 273: 5093-5100.
2. Stephan JL, Vlekova V, Le Deist F, Blanche S, Donadieu J, De Saint-Basile G, Durandy A, Griscelli C, Fischer A: Severe combined immunodeficiency: a retrospective single-center study of clinical presentation and outcome in 117 patients. J Pediatr 1993; 123: 564-572. (Pubitemid 23287526)
3. Wakamiya M, Blackburn MR, Jurecic R, McArthur MJ, Geske RS, Cartwright J Jr, Mitani K, Vaishnav S, Belmont JW, Kellems RE, Finegold MJ, Montgomery CA Jr, Bradley A, Caskey CT: Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice. Proc Natl Acad Sci USA 1995; 92: 3673-3677.
4. Ferrari G, Rossini S, Nobili N, Maggioni D, Garofalo A, Giavazzi R, Mavilio F, Bordignon C: Transfer of the ADA gene into human ADA-deficient T lymphocytes reconstitutes specific immune functions. Blood 1992; 80: 1120-1124.
5. Hershfield MS: Adenosine deaminase deficiency: clinical expression, molecular basis, and therapy. Semin Hematol 1998; 35: 291-298.
6. Saitoh M, Nagai K, Nakagawa K, Yamamura T, Yamamoto S, Nishizaki T: Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase. Biochem Pharmacol 2004; 67: 2005-2011.
7. Sai K, Yang D, Yamamoto H, Fujikawa H, Yamamoto S, Nagata T, Saito M, Yamamura T, Nishizaki T: A 1 adenosine receptor signal and AMPK involving caspase-9/-3 activation are responsible for adenosine-induced RCR-1 astrocytoma cell death. Neurotoxicology 2006; 27: 458-467.
8. Yang D, Yaguchi T, Yamamoto H, Nishizaki T: Intracellularly transported adenosine induces apoptosis in HuH-7 human hepatoma cells by downregulating c-FLIP expression causing caspase-3/-8 activation. Biochem Pharmacol 2007; 73: 1665-1675.
9. Yasuda Y, Saito M, Yamamura T, Yaguchi T, Nishizaki T: Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A 2a adenosine receptors. J Gastroenterol 2009; 44: 56-65.