Effects of levetiracetam on hippocampal kindling in Noda epileptic rats

Brain Research

Volumn 1309, Issue , 2010, Pages 104-109

  Ishimaru, Yuji ^a   Chiba, Shigeru ^a   Serikawa, Tadao ^b   Sasa, Masashi ^c   Inaba, Hiroko ^a   Tamura, Yoshiyuki ^a   Ishimoto, Takahiro ^a   Takasaki, Hideki ^a   Sakamoto, Kazutaka ^a   Yamaguchi, Kazuhide ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c Nagisa Hospital   (Japan)

Author keywords

Antiepileptic drug; Brainstem; Epilepsy; Secondary generalization

Indexed keywords

ETIRACETAM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN STEM; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; ELECTROSTIMULATION; EPILEPSY; GRAND MAL SEIZURE; HIPPOCAMPUS; KINDLING; LIMBIC CORTEX; MALE; NODA EPILEPTIC RAT; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; SEIZURE SUSCEPTIBILITY; WISTAR RAT;

ANIMALS; ANTICONVULSANTS; BRAIN STEM; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DRUG ADMINISTRATION SCHEDULE; ELECTRIC STIMULATION; EPILEPSY; FUNCTIONAL LATERALITY; GENETIC PREDISPOSITION TO DISEASE; HIPPOCAMPUS; KINDLING, NEUROLOGIC; MALE; NEURAL INHIBITION; NEURAL PATHWAYS; PIRACETAM; RATS; RATS, MUTANT STRAINS; RATS, WISTAR; TREATMENT OUTCOME;

RATTUS; RATTUS NORVEGICUS;

EID: 72149106454     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.10.056     Document Type: Article

References (38)

1. Bajjalieh S.M., Frantz G.D., Weimann J.M., McConnell S.K., and Scheller R.H. Differential expression of synaptic vesicle protein 2 (SV2) isoforms. J. Neurosci. 14 (1994) 5223-5235
2. Chiba S., and Wada J.A. Kindling of the interpeduncular nucleus and its influence on subsequent amygdala kindling in rats. Epilepsia 36 (1995) 410-415
3. Dedeurwaerdere S., Boon P., De Smedt T., Claeys P., Raedt R., Bosman T., Van Hese P., Van Maele G., and Vonck K. Chronic levetiracetam treatment early in life decreases epileptiform events in young GAERS, but does not prevent the expression of spike and wave discharges during adulthood. Seizure 14 (2005) 403-411
4. Faingold C.L., and Randall M.E. Pontine reticular formation neurons exhibit a premature and precipitous increase in acoustic responses prior to audiogenic seizures in genetically epilepsy-prone rats. Brain Res. 704 (1995) 218-226
5. Faingold C.L., and Randall M.E. Neurons in the deep layers of superior colliculus play a critical role in the neuronal network for audiogenic seizures: mechanisms for production of wild running behavior. Brain Res. 815 (1999) 250-258
6. French J., Edrich P., and Cramer J.A. A systematic review of the safety profile of levetiracetam: a new antiepileptic drug. Epilepsy Res. 47 (2001) 77-90
7. Glien M., Brandt C., Potschka H., and Löscher W. Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy. Epilepsia 43 (2002) 350-357
8. Hanaya R., Sasa M., Kiura Y., Ishihara K., Serikawa T., and Kurisu K. Epileptiform burst discharges in hippocampal CA3 neurons of young but not mature Noda epileptic rats (NER). Brain Res. 950 (2002) 317-320
9. Iida K., Sasa M., Serikawa T., Noda A., Ishihara K., Akimitsu T., Hanaya R., Arita K., and Kurisu K. Induction of convulsive seizures by acoustic priming in a new genetically defined model of epilepsy (Noda epileptic rat: NER). Epilepsy Res. 30 (1998) 115-126
10. Ji-qun C., Ishihara K., Nagayama T., Serikawa T., and Sasa M. Long-lasting antiepileptic effects of levetiracetam against epileptic seizures in the spontaneously epileptic rat (SER): differentiation of levetiracetam from conventional antiepileptic drugs. Epilepsia 46 (2005) 1362-1370
11. 2+ channels in abnormal excitability of hippocampal CA3 pyramidal cells in noda epileptic rats. J. Pharmacol. Sci. 91 (2003) 137-144
12. Klitgaard H., Matagne A., Gobert J., and Wölfert E. Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. Eur. J. Pharmacol. 353 (1998) 191-206
13. Löscher W. Genetic animal models of epilepsy as a unique resource for the evaluation of anticonvulsant drugs. A review. Methods Find. Exp. Clin. Pharmacol. 6 (1984) 531-547
14. Löscher W., H?nack D., and Rundfeldt C. Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy. J. Pharmacol. Exp. Ther. 284 (1998) 474-479
15. Lynch B.A., Lambeng N., Nocka K., Kensel-Hammes P., Bajjalieh S.M., Matagne A., and Fuks B. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 9861-9866
16. Madeja M., Margineanu D.G., Gorji A., Siep E., Boerrigter P., Klitgaard H., and Speckmann E.J. Reduction of voltage-operated potassium currents by levetiracetam: a novel antiepileptic mechanism of action. Neuropharmacology 45 (2003) 661-671
17. Maihara T., Noda A., Yamazoe H., Voigt B., Kitada K., and Serikawa T. Chromosomal mapping of genes for epilepsy in NER: a rat strain with tonic-clonic seizures. Epilepsia 41 (2000) 941-949
18. Margineanu D.G., and Klitgaard H. Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs. Pharmacol. Res. 42 (2000) 281-285
19. Margineanu D.G., and Klitgaard H. Levetiracetam has no significant gamma-aminobutyric acid-related effect on paired-pulse interaction in the dentate gyrus of rats. Eur. J. Pharmacol. 466 (2003) 255-261
20. Nadler J.V. Kainic acid as a tool for the study of temporal lobe epilepsy. Life Sci. 29 (1981) 2031-2042
21. 2+ current in pyramidal neurones of rat hippocampal slices. Neurosci. Lett. 306 (2001) 5-8
22. Noda A., Hashizume R., Maihara T., Tomizawa Y., Ito Y., Inoue M., Kobayashi K., Asano Y., Sasa M., and Serikawa T. NER rat strain: a new type of genetic model in epilepsy research. Epilepsia 39 (1998) 99-107
23. Omori N., Tabata K., Ishimaru Y., Ishimoto T., Tamura Y., Mutoh F., Chiba S., Ohta S., Kiura Y., Akimitsu T., Hanaya R., Kurisu K., Sasa M., and Serikawa T. Amygdala kindling in Noda epileptic rat (NER). (in Japanese). Jpn. J. Clin. Neurophysiol. 29 2 (2001) 200
24. Patsalos P.N. Pharmacokinetic profile of levetiracetam: toward ideal characteristics. Pharmacol. Ther. 85 (2000) 77-85
25. Paxinos, G., Watson, C., 1998. The Rat Brain in Stereotaxic Coordinates, Fourth Edition. Academic Press, Sydney.
26. Racine R.J. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 32 (1972) 281-294
27. Rigo J.M., Hans G., Nguyen L., Rocher V., Belachew S., Malgrange B., Leprince P., Moonen G., Selak I., Matagne A., and Klitgaard H. The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents. Br. J. Pharmacol. 136 (2002) 659-672
28. Rogawski M.A. Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. 69 (2006) 273-294
29. Sasa M., Hanaya R., Iida K., Akimitsu T., Kurisu K., Noda A., and Serikawa T. A novel epilepsy animal model (NER). Nihon Shinkei Seishin Yakurigaku Zasshi 17 (1997) 35-38
30. Sills G.J., Leach J.P., Fraser C.M., Forrest G., Patsalos P.N., and Brodie M.J. Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain. Eur. J. Pharmacol. 325 (1997) 35-40
31. Stratton S.C., Large C.H., Cox B., Davies G., and Hagan R.M. Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling model. Epilepsy Res. 53 (2003) 95-106
32. Tilz C., Stefan H., Hopfengaertner R., Kerling F., Genow A., and Wang-Tilz Y. Influence of levetiracetame on ictal and postictal EEG in patients with partial seizures. Eur. J. Neurol. 13 (2006) 1352-1358
33. Tong X., and Patsalos P.N. A microdialysis study of the novel antiepileptic drug levetiracetam: extracellular pharmacokinetics and effect on taurine in rat brain. Br. J. Pharmacol. 133 (2001) 867-874
34. Turski W.A., Cavalheiro E.A., Schwarz M., Czuczwar S.J., Kleinrok Z., and Turski L. Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behav. Brain Res. 9 (1983) 315-335
35. Turski W.A., Cavalheiro E.A., Coimbra C., Coimbra C., Ikonomidou-Turski C., and Turski L. Only certain antiepileptic drugs prevent seizures induced by pilocarpine. Brain Res. 434 (1987) 281-305
36. van Vliet E.A., van Schaik R., Edelbroek P.M., da Silva F.H., Wadman W.J., and Gorter J.A. Development of tolerance to levetiracetam in rats with chronic epilepsy. Epilepsia 49 (2008) 1151-1159
37. Yan H.D., Ji-qun C., Ishihara K., Nagayama T., Serikawa T., and Sasa M. Separation of antiepileptogenic and antiseizure effects of levetiracetam in the spontaneously epileptic rat (SER). Epilepsia 46 (2005) 1170-1177
38. 2+ currents. Seizure 10 (2001) 279-286