A possible correlation between the correction of endothelial dysfunction and normalization of high blood pressure levels by 1,3,4-oxadiazole derivative, an L-type Ca2+ channel blocker in deoxycorticosterone acetate and NG-nitro-l-arginine hypertensive rats

Chemico-Biological Interactions

Volumn 183, Issue 2, 2010, Pages 327-331

  Bankar, Girish R ^a   Nampurath, Gopalan Kutty ^a   Nayak, Pawan G ^a   Bhattacharya, Shoumyo ^a  

^a MANIPAL COLLEGE OF PHARMACEUTICAL SCIENCES   (India)

Author keywords

1,3,4 Oxadiazole; Aortic rings; DOCA salt induced hypertension; Endothelial dysfunction; L NNA induced hypertension

Indexed keywords

1,3,4 OXADIAZINE DERIVATIVE; 1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 [3 ACETYL 5 (PYRIDINE 3 YL) 2,3 DIHYDRO 1,3,4 OXADIAZOLE 2 YL]PHENYL ACETATE; ACETYLCHOLINE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; DEOXYCORTICOSTERONE ACETATE; GLIBENCLAMIDE; INDOMETACIN; N(G) NITROARGININE; NIFEDIPINE; NORADRENALIN; NOX 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; AORTA; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; HYPERTENSION; MALE; NONHUMAN; RAT; SYSTOLIC BLOOD PRESSURE; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASODILATATION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA, THORACIC; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; DESOXYCORTICOSTERONE; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GLYBURIDE; HYPERTENSION; INDOMETHACIN; MALE; NITROARGININE; NOREPINEPHRINE; OXADIAZOLES; QUINOXALINES; RATS; RATS, WISTAR; VASODILATION; VASODILATOR AGENTS;

RATTUS;

EID: 72149100142     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.11.001     Document Type: Article

References (19)

1. Yanagisawa M., Kuruhara H., Kimura S., Mitsui Y., Kobayashi M., Watanabe T.X., and Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332 (1998) 411-415
2. Vanhoutte P.M. Other endothelium derived relaxation factors. Circulation 87 (1992) V9-V17
3. Panza J.A., Quyyumi A.A., and Brush J.E. Abnormal endothelium dependent vascular relaxation in patients with essential hypertension. N. Engl. J. Med. 323 (1990) 22-37
4. Taddei S., Virdis A., Mattei P., and Salvetti A. Vasodilation to acetylcholine in primary and secondary forms of human hypertension. Hypertension 21 (1993) 929-933
5. Luscher T.F., Diederich D., Weber E., Vanhoutte P.M., and Buhler F.R. Endothelium-dependent responses in carotid and renal arteries of normotensive and hypertensive rats. Hypertension 11 (1988) 573-578
6. Paniagua O.A., Bryant M.B., and Panza J.A. Role of endothelial nitric oxide in shear stress-induced vasodilation of human microvasculature: diminished activity in hypertensive and hypercholesterolemic patients. Circulation 103 (2001) 1752-1758
7. Carvalho M.H.C., Fortes Z.B., Nigro D., Oliveira M.A., and Scivoletto R. The role of thromboxane A2 in the altered microvascular reactivity in two-kidney, one-clip hypertension. Endothelium 5 (1997) 167-178
8. Shirasaki Y., Su C., Lee T.J.F., Kolm P., Kline W.H.J.R., and Nickols G. Endothelial modulation of vascular relaxation to nitrovasodilators in aging and hypertension. J. Pharmacol. Exp. Ther. 239 (1986) 861-866
9. Cordellini S., Carvalho M.H.C., Scivoletto R., Fortes Z.B., and Nigro D. Indirect evidence for an endothelium-derived contracting factor release in aorta of deoxycorticosterone acetate-salt hypertensive rats. J. Hypertens. 8 (1990) 53-60
10. Schiffrin E.L., and Deng L.Y. Comparison of effects of angiotensin converting enzyme inhibition and β blockade for 2 years on function of arteries from hypertensive patients. Hypertension 25 (1995) 699-703
11. Schiffrin E.L., and Deng L.Y. Structure and function of resistance arteries of hypertensive patients treated with a β-blocker or a calcium channel antagonist. J. Hypertens. 14 (1996) 1247-1255
12. Cuman R.K.N., Nigro D., Carvalho M.H.C., Scivoletto R., and Fortes Z.B. Influence of hydralazine treatment on the vascular reactivity of DOCA-salt hypertensive rats. Endothelium 2 (1994) 105-111
13. Sharma A.K., and Srinivasan B.P. Triple verses glimepiride plus metformin therapy on cardiovascular risk biomarkers and diabetic cardiomyopathy in insulin resistance type 2 diabetes mellitus rats. Eur. J. Pharm. Sci. 38 (2009) 433-444
14. Budriesi R., Cosimelli B., et al. Cardiovascular characterization of [1,4]thiazino[3,4-c][1,2,4]oxadiazol-1-one derivatives: selective myocardial calcium channel modulators. J. Med. Chem. 45 (2002) 3475-3481
15. Budriesi R., Cosimelli B., et al. L-type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives. J. Med. Chem. 52 (2009) 2352-2362
16. Bankar G.R., Nandakumar K., Nayak P.G., Thakur A., Chamallamudi M.R., and Nampurath G.K. Vasorelaxant effect in rat aortic rings through calcium channel blockage: a preliminary in vitro assessment of a 1,3,4-oxadiazole derivative. Chem. Biol. Int. 181 (2009) 377-382
17. Bockman C.S., Jeffries W.B., Pettinger W.A., and Abel P.W. Enhanced release of endothelium-derived relaxing factor in mineralocorticoid hypertension. Hypertension 20 (1992) 304-313
18. Cocks T.M. Endothelium dependent vasodilator mechanisms. In: Garland C.J., and Angus J.A. (Eds). Pharmacology of Vascular Smooth Muscle (1996), Oxford University Press, New York, NY 233-251
19. Nelson M.T., and Quayle J.M. Physiological roles and properties of potassium channels in arterial smooth muscle. Am. J. Physiol. 268 (1995) 799-822