Vasorelaxant effect in rat aortic rings through calcium channel blockage: A preliminary in vitro assessment of a 1,3,4-oxadiazole derivative

Chemico-Biological Interactions

Volumn 181, Issue 3, 2009, Pages 377-382

  Bankar, Girish R ^a   Nandakumar, K ^a   Nayak, Pawan G ^a   Thakur, Anjali ^a   Chamallamudi, Mallikarjuna Rao ^a   Nampurath, Gopalan Kutty ^a  

^a MANIPAL COLLEGE OF PHARMACEUTICAL SCIENCES   (India)

Author keywords

1,3,4 Oxadiazoles; Aortic rings; Calcium influx; Hypertension; Vasorelaxation

Indexed keywords

1,3,4 OXADIAZOLE DERIVATIVE; 4 [3 ACETYL 5 (PYRIDIN 3 YL) 2,3 DIHDYRO 1,3,4 OXADIAZOL 2 YL]PHENYLACETIC ACID; CALCIUM; CALCIUM CHANNEL L TYPE; NORADRENALIN; PHENYLEPHRINE; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL TISSUE; AORTA MEDIA; ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; IN VITRO STUDY; MALE; NONHUMAN; RAT; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; AORTA; CALCIUM CHANNEL BLOCKERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NOREPINEPHRINE; OXADIAZOLES; PHENYLEPHRINE; POTASSIUM CHLORIDE; RATS; RATS, WISTAR; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; VASODILATION; VERAPAMIL;

ANGINA; RATTUS;

EID: 70249122305     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.07.014     Document Type: Article

References (19)

1. Burt V., Whelton P., Roccella E.J., et al. Prevalence on hypertension in the US adult population: results from the third National Health and Nutrition Examination Survey, 1988-1991. Hypertension 25 (1995) 305-313
2. Victor V.L., et al. Impaired vasodilator activity in deoxycorticosterone acetate-salt hypertension is associated with increased protein O-GlcNAcylation. Hypertension 53 (2009) 166-174
3. Ayotunde S.O., et al. Cyclo-oxygenase-2, endothelium and aortic reactivity during deoxycorticosterone acetate salt-induced hypertension. J. Hypertens. 23 (2005) 1025-1036
4. El-Emam A.A., Al-Deeb O.A., Al-Omar M., and Lehmann. Synthesis, antimicrobial and anti-HIV activity of certain 5-(1-adamantyl)-2-substituted thio-1,3,4-oxadiazoles and 5-(1-adamantyl)-3-substitutedaminomethyl-1,3,4-oxadiazolin-2-thiones. Bioorg. Med. Chem. 12 (2004) 5107-5113
5. Kucukguzel S.G., Oruc E.E., Rollas S., Sahin F., and Ozbek. Synthesis, characterization and biological activity of novel 4-thiazolidinones 1,3,4-oxadiazoles and some related compounds. Eur. J. Med. Chem. 37 (2002) 197-206
6. Kagthara P.R., Shah N.S., Doshi R.K., and Parekh. Synthesis of 2,5-disubstituted-1,3,4-oxadiazoles as biologically active heterocycles. Indian J. Chem. 38B (1999) 572-576
7. Santagati M., Modica M., Santagati A., Russo F., Caruso A., Cutuli V., Dipietro E., and Amico Roxas M. Synthesis and pharmacological properties of benzothiazole 1,3,4-oxadiazole and 1,2,4-thiadiazole derivatives. Pharmazie 49 (1994) 880-884
8. Unangast P.C., Shrum G.P., Conner D.T., Dyer C.D., and Schrier. Novel 1,3,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipooxygenase and cyclooxygenase inhibitors. J. Med. Chem. 35 (1992) 3691-3698
9. Khan M.S.Y., Khan R.M., and Drabu S. Anticonvulsant and antibacterial activity of some new 1,3,4-oxadiazole derivatives. Indian J. Heterocycl. Chem. 11 (2001) 119-122
10. Chrysiha E.D., Kosmopoulou M.N., Tiraidis C., Kardakaris R., et al. Kinetic and crystallographic studies on 2-(β-d-glucopyranosyl)-5-methyl-1,3,4-oxadiazole-benzthiazole and -benzimidazole, inhibitors of muscle glycogen phosphorylase. B. Evidence for a new binding site. Protein Sci. 14 (2005) 873-878
11. Maslat A.O., Abussaud M., Tashtoush H., et al. Synthesis, antibacterial, antifungal activity and genotoxic activity of bis-1,3,4-oxadiazole derivatives. Pol. J. Pharmacol. 54 (2002) 55-59
12. Budriesi R., Cosimelli B., et al. Cardiovascular characterization of [1,4] thiazino[3,4-c][1,2,4]oxadiazol-1-one derivatives: selective myocardial calcium channel modulators. J. Med. Chem. 45 (2002) 3475-3481
13. Budriesi R., Cosimelli B., et al. L-type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives. J. Med. Chem. 52 (2009) 2352-2362
14. Zahra F.H., Mostafa J., Ahmad T., and Mohammad F. The antihypertensive and vasodilator effects of aqueous extract from Berberis vulgaris fruit on hypertensive rats. Phytother. Res. 19 (2005) 222-225
15. Karaki H., Ozaki H., Hori M., et al. Calcium movements, distribution, and functions in smooth muscle. Pharmacol. Rev. 49 (1997) 157-230
16. Spedding M., and Cavero I. Calcium antagonists: a class of drugs with a bright future. Part II. Determination of basic pharmacological properties. Life Sci. 35 (1984) 575-587
17. Ruegg U.T., Wallnofer A., Weir S., and Cauvin C. Receptor operated calcium-permeable channels in vascular smooth muscle. J. Cardiovasc. Pharmacol. 14 (1989) 49-58
18. McFadzean I., and Gibson A. The developing relationship between receptor-operated and store-operated calcium channels in smooth muscle. Br. J. Pharmacol. 35 (2002) 1-13
19. 2+ channels in the rat aorta. Chin. J. Physiol. 39 (1996) 1-8