Design, synthesis and biological evaluation of a bivalent μ opiate and adenosine A1 receptor antagonist

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 23, 2009, Pages 6736-6739

  Mathew, Smitha C ^a   Ghosh, Nandita ^a   By, Youlet ^b   Berthault, Aurélie ^a   Virolleaud, Marie Alice ^a   Carrega, Louis ^b   Chouraqui, Gaëlle ^a   Commeiras, Laurent ^a   Condo, Jocelyne ^b   Attolini, Mireille ^a   Gaudel Siri, Anouk ^a   Ruf, Jean ^b   Parrain, Jean Luc ^a   Rodriguez, Jean ^a   Guieu, Régis ^b,c  

^a AIX MARSEILLE UNIVERSITÉ   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE   (France)

Author keywords

A1 receptors; Adenosine; Bivalents antagonists; Fentanyl; Receptors

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSYLFENTANYL; CYCLIC AMP; CYCLOPENTYLADENOSINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR ANTAGONIST; NALOXONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; FEMALE; LATENT PERIOD; LD 50; NOCICEPTION; NONHUMAN; PAIN; PROTEIN EXPRESSION; TAIL FLICK TEST;

ANIMALIA;

EID: 72049130583     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.112     Document Type: Article

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