Simultaneous determination of epothilone D and its hydrolytic metabolite in human plasma by high performance liquid chromatography-tandem mass spectrometry for pharmacokinetic studies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 29, 2009, Pages 3748-3752

  Zhang, Chunling ^a,b   Zhao, Lanjiao ^a,b   Qi, Wenyuan ^a   Meng, Zhiyun ^a   Sun, Guoxiang ^b   Dou, Guifang ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Epothilone D; HPLC MS MS; Hydrolytic metabolite; Pharmacokinetics

Indexed keywords

ANALYTICAL COLUMNS; ANALYTICAL METHOD; CONCENTRATION RANGES; DILUTION EFFECT; ELECTROSPRAY IONIZATION SOURCES; EPOTHILONES; EXTRACTION RECOVERY; HIGH SENSITIVITY; HPLC-MS/MS; HUMAN PLASMAS; HYDROLYTIC METABOLITE; INTERNAL STANDARDS; ION PAIRS; LINEAR CALIBRATION CURVE; LOWER LIMITS; MATRIX EFFECTS; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; SELECTED REACTION MONITORING; SIMULTANEOUS DETERMINATIONS; TANDEM MASS SPECTROMETRIC;

ACETONITRILE; BIOMOLECULES; CHROMATOGRAPHIC ANALYSIS; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; PHARMACOKINETICS; PLASMA (HUMAN); POSITIVE IONS;

METABOLISM;

DRUG METABOLITE; EPOTHILONE C; EPOTHILONE D; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CALIBRATION; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HYDROLYSIS; DRUG INFUSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MASS SPECTROMETER; PLASMA; PRIORITY JOURNAL; QUALITY CONTROL; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EPOTHILONES; HUMANS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 72049126135     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.08.052     Document Type: Article

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