Erythropoietin protects neurons against chemical hypoxia and cerebral ischemic injury by up-regulating Bcl-xL expression

Journal of Neuroscience Research

Volumn 67, Issue 6, 2002, Pages 795-803

  Wen, Tong Chun ^a   Sadamoto, Yasutaka ^a   Tanaka, Junya ^a   Zhu, Peng Xiang ^a   Nakata, Kimihiko ^a   Yong Jie, Ma ^a   Hata, Ryuji ^a   Sakanaka, Masahiro ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Bcl xL; Cerebral ischemia; Chemical hypoxia; Erythropoietin; Neuroprotection

Indexed keywords

MESSENGER RNA; PROTEIN BCL XL; RECOMBINANT ERYTHROPOIETIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; EMBRYO; GENE EXPRESSION REGULATION; GERBIL; HIPPOCAMPUS; HYPOXIA; IMMUNOBLOTTING; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; AVOIDANCE LEARNING; BCL-X PROTEIN; BRAIN ISCHEMIA; CELL COUNT; CELL HYPOXIA; CELLS, CULTURED; CEREBRAL CORTEX; ERYTHROPOIETIN; GENE EXPRESSION; GERBILLINAE; MALE; NEURONS; NEUROPROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; REACTION TIME; RNA, MESSENGER;

EID: 0037086295     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10166     Document Type: Article

References (42)

1. Effect of recombinant human erythropoietin on cerebral ischemia following experimental subarachnoid hemorrhage
2. Behavioral, electroencephalographic and histopathological studies on Mongolia gerbils with occluded common carotid arteries
3. Apoptosis induced by erythroid differentiation of human leukemia cell lines is inhibited by Bcl-x
4. A potential role for erythropoietin in focal permanent cerebral ischemia in mice
5. The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136
6. Bcl-x, Bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
7. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury
8. Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation
9. Localization of specific erythropoietin binding sides in defined areas of the mouse brain
10. Bcl-xL is the major Bcl-x mRNA form expressed during murine development and its product localization to mitochondria
11. Bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent cell death
12. Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by Bcl-x but not Bcl- 2
13. GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating Bcl-xL expression
14. Brainstem auditory evoked potentials during brainstem ischemia and reperfusion in gerbils
15. Distinct signaling from stem cell factor and erythropoietin in HCD57 cells
16. Erythropoietin: Structure, control of production, and function
17. Role of the kidney in erythropoiesis
18. Erythropoietin and erythropoietin receptor in the developing human central nervous system
19. Caldesmon and low Mr isoform of tropomyosin are localized in neuronal growth cones
20. Immunohistochemical analysis of in vivo patterns of Bcl-x expression
21. Cleavage of structural proteins during the assembly of the head of bacteriophage T 4
22. Erythropoietin gene expression in human, monkey and murine brain
23. Detection of erythropoietin in human liquor: Intrinsic erythropoietin production in the brain
24. A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes
25. Transient forebrain ischemia of three-minute duration consistently induces severe neuronal damage in field CA1 of the hippocampus in the normothermic gerbil
26. Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced nenronal death
27. Epidermal growth factor protects neuronal cells in vivo and in vitro against transient forebrain ischemia- and free radical-induced injuries
28. Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways
29. Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery
30. In vivo evidence that erythropoietin protects neurons from ischemic damage
31. Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-xL and Bcl-2
32. Erythropoietin protects cultured cortical neurons, but not astroglia, from hypoxia and AMPA toxicity
33. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
34. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/-mice: A direct role for Stat5 in Bcl-X(L) induction
35. Stem cell factor and erythropoietin inhibit apoptosis of human erythroid progenitor cells through different signalling pathways
36. Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia
37. Microglial ramification requires non-diffusible factors derived from astrocytes
38. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheet: Procedure and some applications
39. Ginseng root prevents learning disability and neuronal loss in gerbils with 5-min forebrain ischemia
40. Interleukin 3 prevents delayed neuronal death in the hippocampal CA1 field
41. Liver as the primary site of erythropoietin formation in the fetus