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Volumn 3, Issue 3 SUPPL. 2, 2009, Pages

The role of 5-alpha reductase inhibitors in prostate pathophysiology: Is there an additional advantage to inhibition of type 1 isoenzyme?

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EID: 72049121194     PISSN: 19116470     EISSN: 19116470     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (38)

References (34)
  • 1
    • 0014429464 scopus 로고
    • The conversion of testosterone to 5-alpha-androstan-17-beta-ol-3-one by rat prostate in vivo and in vitro
    • Bruchovsky N, Wilson JD. The conversion of testosterone to 5-alpha-androstan-17-beta-ol-3-one by rat prostate in vivo and in vitro. J Biol Chem 1968; 243: 2012-21.
    • (1968) J. Biol. Chem. , vol.243 , pp. 2012-2021
    • Bruchovsky, N.1    Wilson, J.D.2
  • 2
    • 0014430280 scopus 로고
    • The intranuclear binding of testosterone and 5-alpha-androstan- 17-beta-ol-3-one by rat prostate
    • Bruchovsky N, Wilson JD. The intranuclear binding of testosterone and 5-alpha-androstan- 17-beta-ol-3-one by rat prostate. J Biol Chem 1968; 243: 5953-60.
    • (1968) J. Biol. Chem. , vol.243 , pp. 5953-5960
    • Bruchovsky, N.1    Wilson, J.D.2
  • 3
    • 0014424444 scopus 로고
    • Selective retention of dihydrotestosterone by prostatic nuclei
    • Anderson KM, Liao S. Selective retention of dihydrotestosterone by prostatic nuclei. Nature 1968; 219: 277-9.
    • (1968) Nature , vol.219 , pp. 277-279
    • Anderson, K.M.1    Liao, S.2
  • 4
    • 38449104723 scopus 로고    scopus 로고
    • Role of 5 alpha-reductase inhibitors in the management of prostate cancer
    • Hudak SJ, Hernandez J, Thompson IM. Role of 5 alpha-reductase inhibitors in the management of prostate cancer. Clin Interv Aging 2006; 1: 425-31.
    • (2006) Clin. Interv. Aging , vol.1 , pp. 425-431
    • Hudak, S.J.1    Hernandez, J.2    Thompson, I.M.3
  • 5
    • 44049101301 scopus 로고    scopus 로고
    • The role of testosterone in the pathogenesis of prostate cancer
    • Imamoto T, Suzuki H, Yano M, et al. The role of testosterone in the pathogenesis of prostate cancer. Int J Urol 2008; 15: 472-80.
    • (2008) Int. J. Urol. , vol.15 , pp. 472-480
    • Imamoto, T.1    Suzuki, H.2    Yano, M.3
  • 6
    • 37349107226 scopus 로고    scopus 로고
    • Type 1 and type 2 5alpha-reductase expression in the development and progression of prostate cancer
    • Thomas LN, Douglas RC, Lazier CB, et al. Type 1 and type 2 5alpha-reductase expression in the development and progression of prostate cancer. Eur Urol 2008; 53: 244-52.
    • (2008) Eur. Urol. , vol.53 , pp. 244-252
    • Thomas, L.N.1    Douglas, R.C.2    Lazier, C.B.3
  • 8
    • 0033305674 scopus 로고    scopus 로고
    • Androgen-induced regrowth in the castrated rat ventral prostate: Role of 5alpha-reductase
    • Wright AS, Douglas RC, Thomas LN, et al. Androgen-induced regrowth in the castrated rat ventral prostate: role of 5alpha-reductase. Endocrinology 1999; 140: 4509-15.
    • (1999) Endocrinology , vol.140 , pp. 4509-4515
    • Wright, A.S.1    Douglas, R.C.2    Thomas, L.N.3
  • 9
    • 0034743524 scopus 로고    scopus 로고
    • Inhibition of 5alpha-reductase in rat prostate reveals differential regulation of androgen-response gene expression by testosterone and dihydrotestosterone
    • Dadras SS, Cai X, Abasolo I, et al. Inhibition of 5alpha-reductase in rat prostate reveals differential regulation of androgen-response gene expression by testosterone and dihydrotestosterone. Gene Expr 2001; 9: 183-94.
    • (2001) Gene Expr. , vol.9 , pp. 183-194
    • Dadras, S.S.1    Cai, X.2    Abasolo, I.3
  • 10
    • 17644362707 scopus 로고    scopus 로고
    • Differential alterations in 5alpha-reductase type 1 and type 2 levels during development and progression of prostate cancer
    • Thomas LN, Lazier CB, Gupta R, et al. Differential alterations in 5alpha-reductase type 1 and type 2 levels during development and progression of prostate cancer. Prostate 2005; 63: 231-9.
    • (2005) Prostate , vol.63 , pp. 231-239
    • Thomas, L.N.1    Lazier, C.B.2    Gupta, R.3
  • 11
    • 0032588595 scopus 로고    scopus 로고
    • Differences in steroid 5alpha-reductase iso-enzymes expression between normal and pathological human prostate tissue
    • Iehlé C, Radvanyi F, Gil Diez de Medina S, et al. Differences in steroid 5alpha-reductase iso-enzymes expression between normal and pathological human prostate tissue. J Steroid Biochem Mol Biol 1999; 68: 189-95.
    • (1999) J. Steroid Biochem. Mol. Biol. , vol.68 , pp. 189-195
    • Iehlé, C.1    Radvanyi, F.2    De Medina, G.D.S.3
  • 12
    • 20444476601 scopus 로고    scopus 로고
    • Steroid 5alpha-reductase isozymes I and II in recurrent prostate cancer
    • Titus MA, Gregory CW, Ford OH 3rd, et al. Steroid 5alpha-reductase isozymes I and II in recurrent prostate cancer. Clin Cancer Res 2005; 11: 4365-71.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 4365-4371
    • Titus, M.A.1    Gregory, C.W.2    Ford III, O.H.3
  • 13
    • 36749022314 scopus 로고    scopus 로고
    • Levels of 5alpha-reductase type 1 and type are increased in localized high grade compared to low grade prostate cancer
    • Thomas LN, Douglas RC, Lazier CB, et al. Levels of 5alpha-reductase type 1 and type are increased in localized high grade compared to low grade prostate cancer. J Urol 2008; 179: 147-51.
    • (2008) J. Urol. , vol.179 , pp. 147-151
    • Thomas, L.N.1    Douglas, R.C.2    Lazier, C.B.3
  • 14
    • 33746047132 scopus 로고    scopus 로고
    • Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers
    • Xu Y, Dalrymple SL, Becker RE, et al. Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers. Clin Cancer Res 2006; 12: 4072-9.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 4072-4079
    • Xu, Y.1    Dalrymple, S.L.2    Becker, R.E.3
  • 15
    • 42949151909 scopus 로고    scopus 로고
    • 5alpha-reductase inhibitors in benign prostatic hyperplasia and prostate cancer risk reduction
    • Rittmaster RS. 5alpha-reductase inhibitors in benign prostatic hyperplasia and prostate cancer risk reduction. Best Pract Res Clin Endocrinol Metab 2008; 22: 389-402.
    • (2008) Best Pract. Res. Clin. Endocrinol Metab. , vol.22 , pp. 389-402
    • Rittmaster, R.S.1
  • 16
    • 2442545242 scopus 로고    scopus 로고
    • Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor
    • Clark RV, Hermann DJ, Cunningham GR, et al. Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor. J Clin Endocrinol Metab 2004; 89: 2179-84.
    • (2004) J. Clin. Endocrinol Metab. , vol.89 , pp. 2179-2184
    • Clark, R.V.1    Hermann, D.J.2    Cunningham, G.R.3
  • 17
    • 72049126532 scopus 로고    scopus 로고
    • The novel dual 5 alpha-reductase inhibitor, dutasteride, is effective and well-tolerated for benign prostatic hyperplasia in black men
    • poster 635, Madrid; 12-15 March
    • Roehrborn C, Ray P, Gittelmann M, et al. The novel dual 5 alpha-reductase inhibitor, dutasteride, is effective and well-tolerated for benign prostatic hyperplasia in black men. [poster 635]. European Urology Association Annual Meeting; Madrid; 12-15 March, 2003.
    • (2003) European Urology Association Annual Meeting
    • Roehrborn, C.1    Ray, P.2    Gittelmann, M.3
  • 18
    • 33750532965 scopus 로고    scopus 로고
    • The benefits of dual inhibition of 5 alpha reductase
    • Djavan B, Mirone V. The benefits of dual inhibition of 5 alpha reductase. Eur Urol Suppl 2006; 5: 1013.
    • (2006) Eur. Urol Suppl. , vol.5 , pp. 1013
    • Djavan, B.1    Mirone, V.2
  • 19
    • 33750486196 scopus 로고    scopus 로고
    • The effects of the dual 5alpha-reductase inhibitor dutasteride on localized prostate cancer-results from a 4-month pre-radical prostatectomy study
    • Gleave M, Qian J, Andreou C, et al. The effects of the dual 5alpha-reductase inhibitor dutasteride on localized prostate cancer-results from a 4-month pre-radical prostatectomy study. Prostate 2006; 66: 1674-85.
    • (2006) Prostate , vol.66 , pp. 1674-1685
    • Gleave, M.1    Qian, J.2    Andreou, C.3
  • 20
    • 12844279803 scopus 로고    scopus 로고
    • The dual 5-alpha-reductase Inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate
    • Iczkowski KA, Qiu J, Qian J, et al. The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate. Urology 2005; 65: 76-82.
    • (2005) Urology , vol.65 , pp. 76-82
    • Iczkowski, K.A.1    Qiu, J.2    Qian, J.3
  • 21
    • 41149166182 scopus 로고    scopus 로고
    • Prostate-specific antigen and prostate cancer: Prediction, detection and monitoring
    • Lilja H, Ulmert D, Vickers AJ. Prostate-specific antigen and prostate cancer: prediction, detection and monitoring. Nat Rev Cancer 2008; 8: 268-78.
    • (2008) Nat. Rev. Cancer. , vol.8 , pp. 268-278
    • Lilja, H.1    Ulmert, D.2    Vickers, A.J.3
  • 22
    • 0032146642 scopus 로고    scopus 로고
    • Treatment with finasteride preserves usefulness of prostate-specific antigen in the detection of prostate cancer: Results of a randomized, double-blind, placebo-controlled clinical trial
    • Proscar Longterm Efficacy and Safety Study PLESS Study Group
    • Andriole GL, Guess HA, Epstein JI, et al. Treatment with finasteride preserves usefulness of prostate-specific antigen in the detection of prostate cancer: results of a randomized, double-blind, placebo-controlled clinical trial. PLESS Study Group. Proscar Longterm Efficacy and Safety Study. Urology 1998; 52: 195-201.
    • (1998) Urology , vol.52 , pp. 195-201
    • Andriole, G.L.1    Guess, H.A.2    Epstein, J.I.3
  • 23
    • 33746543255 scopus 로고    scopus 로고
    • The interpretation of serum prostate specific antigen in men receiving 5alpha-reductase inhibitors: A review and clinical recommendations
    • Marks LS, Andriole GL, Fitzpatrick JM, et al. The interpretation of serum prostate specific antigen in men receiving 5alpha-reductase inhibitors: a review and clinical recommendations. J Urol 2006; 176: 868-74.
    • (2006) J. Urol. , vol.176 , pp. 868-874
    • Marks, L.S.1    Andriole, G.L.2    Fitzpatrick, J.M.3
  • 24
    • 0025037581 scopus 로고
    • Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone
    • Grino PB, Griffin JE, Wilson JD. Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone. Endocrinology 1990; 126: 1165-72.
    • (1990) Endocrinology , vol.126 , pp. 1165-1172
    • Grino, P.B.1    Griffin, J.E.2    Wilson, J.D.3
  • 25
    • 36949000088 scopus 로고    scopus 로고
    • Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer
    • Uemura M, Tamura K, Chung S, et al. Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. Cancer Sci 2008; 99: 81-6.
    • (2008) Cancer Sci. , vol.99 , pp. 81-86
    • Uemura, M.1    Tamura, K.2    Chung, S.3
  • 26
    • 0037812658 scopus 로고    scopus 로고
    • The influence of finasteride on the development of prostate cancer
    • Thompson IM, Goodman PJ, Tangen CM, et al. The influence of finasteride on the development of prostate cancer. N Engl J Med 2003; 349: 215-24.
    • (2003) N Engl. J. Med. , vol.349 , pp. 215-224
    • Thompson, I.M.1    Goodman, P.J.2    Tangen, C.M.3
  • 27
    • 33744790339 scopus 로고    scopus 로고
    • The pcpt: New findings, new insights, and clinical implications for the prevention of prostate cancer
    • Akduman B, Crawford ED. The PCPT: New findings, new insights, and clinical implications for the prevention of prostate cancer. Eur Urol Suppl 2006; 5: 634.
    • (2006) Eur. Urol Suppl. , vol.5 , pp. 634
    • Akduman, B.1    Crawford, E.D.2
  • 28
    • 48849083217 scopus 로고    scopus 로고
    • The reduce trial: Chemoprevention in prostate cancer using a dual 5alpha-reductase inhibitor, dutasteride
    • Musquera M, Fleshner NE, Finelli A, et al. The REDUCE trial: chemoprevention in prostate cancer using a dual 5alpha-reductase inhibitor, dutasteride. Expert Rev Anticancer Ther 2008; 8: 1073-9.
    • (2008) Expert Rev Anticancer Ther. , vol.8 , pp. 1073-1079
    • Musquera, M.1    Fleshner, N.E.2    Finelli, A.3
  • 29
    • 72049114620 scopus 로고    scopus 로고
    • Dentification and characterization of somatic steroid 5alpha-reductase (Srd5A2) mutations in human prostate cancer tissue
    • Makridakis N, Akalu A, Reichardt JK. dentification and characterization of somatic steroid 5alpha-reductase (SRD5A2) mutations in human prostate cancer tissue. ncogene 2004; 3: 399-405.
    • (2004) Ncogene , vol.3 , pp. 399-405
    • Makridakis, N.1    Akalu, A.2    Reichardt, J.K.3
  • 30
    • 72049083884 scopus 로고    scopus 로고
    • Harmacogenetic analysis of human steroid 5 alpha reductase type II: Comparison of finasteride and dutasteride
    • Makridakis N, Reichardt JK. harmacogenetic analysis of human steroid 5 alpha reductase type II: comparison of finasteride and dutasteride. Mol Endocrinol 2005; 4: 17-23.
    • (2005) Mol. Endocrinol , vol.4 , pp. 17-23
    • Makridakis, N.1    Reichardt, J.K.2
  • 31
    • 72049127695 scopus 로고    scopus 로고
    • Nhancement of intermittent androgen ablation by "off-cycle" maintenance with finasteride in LNCaP prostate cancer xenograft model
    • Eggener SE, Stern JA, Jain PM, et al. nhancement of intermittent androgen ablation by "off-cycle" maintenance with finasteride in LNCaP prostate cancer xenograft model. rostate 2006; 6: 95-502.
    • (2006) Rostate , vol.6 , pp. 95-502
    • Eggener, S.E.1    Stern, J.A.2    Jain, P.M.3
  • 32
    • 72049085703 scopus 로고    scopus 로고
    • Argeting the androgen receptor: Improving outcomes for castration-resistant prostate cancer
    • Scher HI, Buchanan G, Gerald W, et al. argeting the androgen receptor: improving outcomes for castration-resistant prostate cancer. ndocr Relat Cancer 2004; 1: 59-76.
    • (2004) Ndocr Relat Cancer , vol.1 , pp. 59-76
    • Scher, H.I.1    Buchanan, G.2    Gerald, W.3
  • 33
    • 72049086103 scopus 로고    scopus 로고
    • aximal suppression of the androgen axis in clinically localized prostate cancer NCT00298155, ccessed January 16
    • aximal suppression of the androgen axis in clinically localized prostate cancer (NCT00298155). http://www.clinicaltrials.gov/ct2/show/NCT00298155?term= nct00298155&rank=1.accessed January 16, 2009.
    • (2009)
  • 34
    • 85069299857 scopus 로고    scopus 로고
    • Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
    • Locke JA, Guns ES, Lubik AA, et al. Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. ancer Res 2008; 8: 407-15.
    • (2008) Ancer Res. , vol.8 , pp. 407-415
    • Locke, J.A.1    Guns, E.S.2    Lubik, A.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.