Inhibition of 5α-reductase in rat prostate reveals differential regulation of androgen-response gene expression by testosterone and dihydrotestosterone

Gene Expression

Volumn 9, Issue 4-5, 2001, Pages 183-194

  Dadras, S S ^a   Cai, X ^a   Abasolo, I ^a   Wang, Z ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

5 Reductase; Androgen response genes; Dihydrotestosterone; Testosterone

Indexed keywords

ADRENOMEDULLIN; ANDROSTANOLONE; CALRETICULIN; FINASTERIDE; GENE PRODUCT; SPERMIDINE SYNTHASE; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CASTRATION; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE INDUCTION; HORMONAL REGULATION; MALE; METABOLIC INHIBITION; NONHUMAN; PROSTATE; RAT; TISSUE DIFFERENTIATION; TISSUE REGENERATION; ANIMAL; DNA RESPONSIVE ELEMENT; DRUG ANTAGONISM; DRUG POTENTIATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; ORCHIECTOMY; ORGAN SIZE; SPRAGUE DAWLEY RAT; TESTIS;

ANIMALIA;

ANIMALS; DIHYDROTESTOSTERONE; DRUG SYNERGISM; FINASTERIDE; GENE EXPRESSION REGULATION; MALE; ORCHIECTOMY; ORGAN SIZE; PROSTATE; RATS; RATS, SPRAGUE-DAWLEY; RESPONSE ELEMENTS; RNA, MESSENGER; TESTIS; TESTOSTERONE; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 0034743524     PISSN: 10522166     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000001783992551     Document Type: Article

References (40)

1. Effects of intermittent androgen suppression on androgen-dependent tumors. Apoptosis and serum prostate-specific antigen
2. Identification of genes expressed in the rat prostate that are modulated differently by castration and finasteride treatment
3. Intermittent androgen suppression for prostate cancer: Canadian prospective trial and related observation
4. Hormonal effects on cell proliferation in rat prostate
5. The conversion of testosterone to 5-alpha-androstan-17-beta-ol-3-one by rat prostate in vivo and in vitro
6. The intranuclear binding of testosterone and 5-alpha-androstan-17-beta-ol-3-one by rat prostate
7. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
8. Evidence for a non-androgenic role of testis and epididymis in androgen-supported growth of the rat ventral prostate
9. Testosterone and 5 alpha-dihydrotestosterone interact differently with the androgen receptor to enhance transcription of the MMTV-CAT reporter gene
10. Effects of 5 alpha-reductase inhibitors on intraprostatic androgens in the rat
11. Androgen metabolism in the prostate of the finasteride-treated, adult rat: A possible explanation for the differential action of testosterone and 5 alpha-dihydrotestosterone during development of the male urogenital tract
12. Feed-forward control of prostate growth: Dihydrotestosterone induces expression of its own biosynthetic enzyme, steroid 5 alpha-reductase
13. Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone
14. Comparison of the effects of the 5 alpha-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: Dose-response studies
15. Gross dissection of three lobes of the rat prostate
16. Prostatic ductal system in rats: Regional variation in morphological and functional activities
17. Steroid structure and androgenic activity. Specificities involved in the receptor binding and nuclear retention of various androgens
18. Cloning and characterization of TDD5, an androgen target gene that is differentially repressed by testosterone and dihydrotestosterone
19. FR146687, a novel steroid 5 alpha-reductase inhibitor: In vitro and in vivo effects on prostates
20. Morphological and hormonal changes in the ventral and dorsolateral prostatic lobes of rats treated with finasteride, a 5-alpha reductase inhibitor
21. Comparison of finasteride (Proscar), a 5 alpha reductase inhibitor, and various commercial plant extracts in in vitro and in vivo 5 alpha reductase inhibition
22. Differential effect of 5 alpha-reductase inhibition and castration on androgen-regulated gene expression in rat prostate
23. Evidence for atrophy and apoptosis in the ventral prostate of rats given the 5 alpha-reductase inhibitor finasteride
24. Effects of finasteride on the rat ventral prostate
25. Response elements of the androgen-regulated C3 gene
26. The influence of finasteride on the volume of the peripheral and periurethral zones of the prostate in men with benign prostatic hyperplasia
27. Role of epithelial-stromal interactions in the control of gene expression in the prostate: An hypothesis
28. Familial incomplete male pseudohermaphroditism, type 2. Decreased dihydrotestosterone formation in pseudovaginal perineoscrotal hypospadias
29. A gene expression screen
30. Genes regulated by androgen in the rat ventral prostate
31. Binding properties of androgen receptors. Evidence for identical receptors in rat testis, epididymis, and prostate
32. Androgen-induced regrowth in the castrated rat ventral prostate: Role of 5alpha-reductase
33. Relative potency of testosterone and dihydrotestosterone in preventing atrophy and apoptosis in the prostate of the castrated rat
34. Influence of diethylstilbestrol, leuprolelin (a luteinizing hormone-releasing hormone analog), finasteride (a 5 alpha-reductase inhibitor), and castration on the lobar subdivisions of the rat prostate
35. The androgen receptor: An overview
36. ++-binding protein abundantly expressed and regulated by androgen in prostatic epithelial cells
37. Calreticulin expression is associated with androgen regulation of the sensitivity to calcium ionophore-induced apoptosis in LNCaP prostate cancer cells