Comparative study of A HPLC-MS assay versus an UHPLC-MS/MS for anti-tumoral alkyl lysophospholipid edelfosine determination in both biological samples and in lipid nanoparticulate systems

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 31, 2009, Pages 4035-4041

  Estella Hermoso de Mendoza, A ^a   Campanero, M A ^b   Mollinedo, F ^c   Blanco Prieto M J ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

^c UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Biological matrices; Edelfosine; Mass spectrometry; Nanoparticles

Indexed keywords

ANTI-TUMOR AGENTS; APOPTOSIS; ASSAY METHODS; BIOLOGICAL MATRIXES; BIOLOGICAL SAMPLES; CALIBRATION CURVES; COMPARATIVE STUDIES; DETECTOR RESPONSE; EDELFOSINE; GOOD CORRELATIONS; HPLC METHOD; HPLC-MS; IN-VIVO; LINEAR RANGE; LIPID NANOPARTICLES; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MATRIX EFFECTS; NANOPARTICULATE SYSTEM; ORAL ADMINISTRATION; PLASMA SAMPLES; RETENTION TIME; TISSUE HOMOGENATES; TISSUE SAMPLES; TUMOR CELLS; ULTRA HIGH PERFORMANCE;

ASSAYS; CELL DEATH; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; NANOPARTICLES; QUALITY CONTROL; QUALITY FUNCTION DEPLOYMENT; TOTAL QUALITY MANAGEMENT; TUMORS;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ALKYLLYSOPHOSPHOLIPID; ANTINEOPLASTIC AGENT; EDELFOSINE; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG DETERMINATION; DRUG DISTRIBUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; MASS SPECTROMETRY; MOUSE; NONHUMAN; PLASMA; PRIORITY JOURNAL; TISSUE; TISSUE HOMOGENATE; TUMOR; ULTRAHIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; LYSOPHOSPHOLIPIDS; MASS SPECTROMETRY; MICE; NANOPARTICLES; PHOSPHOLIPID ETHERS; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

MUS;

EID: 72049114741     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.10.020     Document Type: Article

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