Loss of calcineurin Aα alters keratinocyte survival and differentiation

Journal of Investigative Dermatology

Volumn 130, Issue 1, 2010, Pages 135-140

  Pena, Juan A ^a   Losi Sasaki, Jacqueline L ^b   Gooch, Jennifer L ^a,c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCINEURIN A ALPHA; CYTOKERATIN 14; INVOLUCRIN; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG; CYTOKERATIN 10; KRT1 10 PROTEIN, MOUSE; KRT1 14 PROTEIN, MOUSE; KRT1-10 PROTEIN, MOUSE; KRT1-14 PROTEIN, MOUSE; NFATC1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; EPIDERMIS CELL; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; AGE; ANIMAL; APOPTOSIS; CONGENITAL MALFORMATION; CYTOLOGY; ENZYMOLOGY; EPIDERMIS; FEMALE; GENETICS; MALE; METABOLISM; MOUSE MUTANT; NEWBORN; PATHOLOGY; PHYSIOLOGY;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CALCINEURIN; CELL DIFFERENTIATION; CELL SURVIVAL; EPIDERMIS; FEMALE; IN SITU NICK-END LABELING; KERATIN-10; KERATIN-14; KERATINOCYTES; MALE; MICE; MICE, MUTANT STRAINS; NFATC TRANSCRIPTION FACTORS;

EID: 72049109706     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.222     Document Type: Article

References (21)

1. Al-Daraji WI, Grant KR, Ryan K, Saxton A, Reynolds NJ (2002) Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A. J Invest Dermatol 118:779-788
2. Bueno OF, Brandt EB, Rothenberg ME, Molkentin JD (2002) Defective T cell development and function in calcineurin Abeta-deficient mice. Proc Natl Acad Sci USA 99:9398-9403
3. Chamian F, Krueger JG (2004) Psoriasis vulgaris: an interplay of T lymphocytes, dendritic cells, and inflammatory cytokines in pathogen-esis. Curr Opin Rheumatol 16:331-337
4. Fisher GJ, Duell EA, Nickoloff BJ, Annesley TM, Kowalke JK, Ellis CN et al. (1988) Levels of cyclosporin in epidermis of treated psoriasis patients differentially inhibit growth of keratinocytes cultured in serum free versus serum containing media. J Invest Dermatol 91:142-146
5. Gafter-Gvili A, Sredni B, Gal R, Gafter U, Kalechman Y (2003) Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes. Am J Physiol Cell Physiol 284:C1593-603
6. Gooch JL, Roberts BR, Cobbs SL, Tumlin JA (2007) Loss of the alpha isoform of calcineurin is sufficient to induce nephrotoxicity and altered expression of TGFbeta. Transplantation 83:439-447
7. Gooch JL, Toro JJ, Guler RL, Barnes JL (2004) Calcineurin A-alpha but not A-beta is required for normal kidney development and function. Am J Pathol 165:1755-1765
8. Lim KK, Su WP, Schroeter AL, Sabers CJ, Abraham RT, Pittelkow MR (1996) Cyclosporine in the treatment of dermatologic disease: an update. Mayo Clin Proc 71:1182-1191
9. Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL (1991) Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66:807-815
10. Mammucari C, Tommasi di Vignano A, Sharov AA, Neilson J, Havrda MC, Roop DR et al. (2005) Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Dev Cell 8:665-676
11. Moriyama M, Durham AD, Moriyama H, Hasegawa K, Nishikawa S, Radtke F, Osawa M (2008) Multiple roles of Notch signaling in the regulation of epidermal development. Dev Cell 14:594-604
12. Nickoloff BJ, Fisher GJ, Mitra RS, Voorhees JJ (1988) Direct cytopathic effects of cyclosporine A on rapidly proliferating cultured keratinocytes and dermal fibroblasts. Transplant Proc 20:85-90
13. Parsons SA, Wilkins BJ, Bueno OF, Molkentin JD (2003) Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice. Mol Cell Biol 23:4331-4343
14. Rao A, Luo C, Hogan P (1997) Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 15:707-747
15. Rusnak F, Mertz P (2000) Calcineurin: form and function. Physiol Rev 80:1483-1521
16. Sakaguchi M, Sonegawa H, Nukui T, Sakaguchi Y, Miyazaki M, Namba M et al. (2005) Bifurcated converging pathways for high Ca2+-and TGFbeta-induced inhibition of growth of normal human keratinocytes. Proc Natl Acad Sci USA 102:13921-13926
17. Santini MP, Talora C, Seki T, Bolgan L, Dotto GP (2001) Cross talk among calcineurin, Sp1/Sp3, and NFAT in control of p21(WAF1/CIP1) expression in keratinocyte differentiation. Proc Natl Acad Sci USA 98:9575-9580
18. Smit NP, Van Rossum HH, Romijn FP, Sellar KJ, Breetveld M, Gibbs S et al. (2008) Calcineurin activity and inhibition in skin and (epi)dermal cell cultures. J Invest Dermatol 128:1686-1690
19. Thelu J, Rossio P, Favier B (2002) Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriases and wound healing. BMC Dermatol 2:1-12
20. Zhang BW, Zimmer G, Chen J, Ladd D, Li E, Alt FW et al. (1996) T cell responses in calcineurin A alpha-deficient mice. J Exp Med 183:413-420
21. Zhuo M, Zhang W, Son H, Mansuy I, Sobel R, Seidman J et al. (1999) A selective role of calcineurin Aalpha in synaptic depotentiation in hippocampus. Proc Natl Acad Sci 96:4650-4655