Gene-lifestyle interactions and their consequences on human health

Medicine and Sport Science

Volumn 54, Issue , 2009, Pages 110-135

  Pomeroy, Jeremy ^a,b   Söderberg, Anna M ^b   Franks, Paul W ^b  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UMEÅ UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DIABETES MELLITUS; DISEASE PREDISPOSITION; GENE; GENETICS; GENOTYPE; HEALTH BEHAVIOR; HEALTH STATUS; HUMAN; HYPERTENSION; LIFESTYLE; OBESITY;

DIABETES MELLITUS; DISEASE SUSCEPTIBILITY; GENES; GENOTYPE; HEALTH BEHAVIOR; HEALTH STATUS; HUMANS; HYPERTENSION; LIFE STYLE; OBESITY;

EID: 72049109692     PISSN: 02545020     EISSN: 16622812     Source Type: Book Series    
DOI: 10.1159/000235700     Document Type: Article

References (61)

1. McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP, Hirschhorn JN: Genomewide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 2008;9:356-369.
2. Roth SM: Perspectives on the future use of genomics in exercise prescription. J Appl Physiol 2008;104:1243-1245.
3. King H, Rewers M: Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. WHO Ad Hoc Diabetes Reporting Group. Diabetes Care 1993;16:157-177.
4. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002;346:393-403.
5. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen- Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Aunola S, Cepaitis Z, Moltchanov V, Hakumaki M, Mannelin M, Martikkala V, Sundvall J, Uusitupa M, the Finnish Diabetes Prevention Study Group: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001;344:1343-1350. (Pubitemid 32378388)
6. Bouchard C, Rankinen T: Individual differences in response to regular physical activity. Med Sci Sports Exerc 2001;33:S446-S451.
7. Neel JV: Diabetes mellitus: a 'thrifty' genotype rendered detrimental by 'progress'? Am J Hum Genet 1962;14:353-362.
8. Chakravarthy MV, Booth FW: Eating, exercise, and 'thrifty' genotypes: connecting the dots toward an evolutionary understanding of modern chronic diseases. J Appl Physiol 2004;96:3-10.
9. Bersaglieri T, Sabeti PC, Patterson N, Vanderploeg T, Schaffner SF, Drake JA, Rhodes M, Reich DE, Hirschhorn JN: Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet 2004;74:1111-1120.
10. Voight BF, Kudaravalli S, Wen X, Pritchard JK: A map of recent positive selection in the human genome. PLoS Biol 2006;4:e72.
11. Speakman JR: A nonadaptive scenario explaining the genetic predisposition to obesity: the 'predation release' hypothesis. Cell Metabolism 2007;6:5-12.
12. Speakman JR: Thrifty genes for obesity and the metabolic syndrome - time to call off the search? Diab Vasc Dis Res 2006;3:7-11.
13. Speakman JR: Thrifty genes for obesity, an attractive but flawed idea, and an alternative perspective: the 'drifty gene' hypothesis. Int J Obes 2008;32:1611- 1617; http://dx.doi.org/10.1038/ijo.2008.161.
14. Prentice A, Hennig BJ, Fulford AJ: Evolutionary origins of the obesity epidemic: natural selection of thrifty genes or genetic drift following predation release? Int J Obes 2008;32:1607-1610.
15. Frayling TM, Timpson NJ, Weedon MN, et al: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:889-894.
16. Franks PW, Jablonski KA, Delahanty L, Hanson RL, Kahn SE, Altshuler D, Knowler WC, Florez JC: The Pro12Ala variant at the peroxisome proliferatoractivated receptor gamma gene and change in obesity- related traits in the Diabetes Prevention Program. Diabetologia 2007;50:2451-2460.
17. Florez JC, Jablonski KA, Kahn SE, Franks PW, Dabelea D, Hamman RF, Knowler WC, Nathan DM, Altshuler D: Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program. Diabetes 2007;56:531-536.
18. Franks PW, Bhattacharyya S, Luan J, Montague C, Brennand J, Challis B, Brage S, Ekelund U, Middelberg RP, O'Rahilly S, Wareham NJ: Association between physical activity and blood pressure is modified by variants in the G-protein coupled receptor 10. Hypertension 2004;43:224-228.
19. Ueno LM, Frazzatto ES, Batalha LT, Trombetta IC, do Socorro Brasileiro M, Irigoyen C, Brum PC, Villares SM, Negrão CE: Alpha2B-adrenergic receptor deletion polymorphism and cardiac autonomic nervous system responses to exercise in obese women. Int J Obes (Lond) 2006;30:214-220.
20. Thamer C, Machann J, Stefan N, Schäfer SA, Machicao F, Staiger H, Laakso M, Böttcher M, Claussen C, Schick F, Fritsche A, Haring HU: Variations in PPARD determine the change in body composition during lifestyle intervention: a wholebody magnetic resonance study. J Clin Endocrinol Metab 2008;93:1497-1500.
21. Naito H, Kamijima M, Yamanoshita O, Nakahara A, Katoh T, Tanaka N, Aoyama T, Gonzalez FJ, Nakajima T: Differential effects of aging, drinking and exercise on serum cholesterol levels dependent on the PPARA-V227A polymorphism. J Occup Health 2007;49:353-362.
22. Andreasen CH, Stender-Petersen KL, Mogensen MS, Torekov SS, Wegner L, Andersen G, Nielsen AL, Albrechtsen A, Borch-Johnsen K, Rasmussen SS, Clausen JO, Sandbaek A, Lauritzen T, Hansen L, Jorgensen T, Pedersen O, Hansen T: Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 2008;57:95-101.
23. Rosado EL, Bressan J, Martins MF, Cecon PR, Martínez JA: Polymorphism in the PPARgamma2 and beta2-adrenergic genes and diet lipid effects on body composition, energy expenditure and eating behavior of obese women. Appetite 2007;49:635-643.
24. Kilpeläinen TO, Lakka TA, Laaksonen DE, Laukkanen O, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, Finnish Diabetes Prevention Study Group: Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes. Physiol Genomics 2007;31:264-272.
25. Wootton PT, Flavell DM, Montgomery HE, World M, Humphries SE, Talmud PJ: Lipoproteinassociated phospholipase A2 A379V variant is associated with body composition changes in response to exercise training. Nutr Metab Cardiovasc Dis 2007;17:24-31.
26. Okura T, Rankinen T, Gagnon J, Lussier-Cacan S, Davignon J, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C: Effect of regular exercise on homocysteine concentrations: the HERITAGE Family Study. Eur J Appl Physiol 2006;98:394-401. (Pubitemid 44490062)
27. Karnehed N, Tynelius P, Heitmann BL, Rasmussen F: Physical activity, diet and gene-environment interactions in relation to body mass index and waist circumference: the Swedish young male twins study. Public Health Nutr 2006;9:851-858.
28. de Luis Roman D, de la Fuente RA, Sagrado MG, Izaola O, Vicente RC: Leptin receptor Lys656Asn polymorphism is associated with decreased leptin response and weight loss secondary to a lifestyle modification in obese patients. Arch Med Res 2006;37:854-859.
29. Ridderstråle M, Johansson LE, Rastam L, Lindblad U: Increased risk of obesity associated with the variant allele of the PPARGC1A Gly482Ser polymorphism in physically inactive elderly men. Diabetologia 2006;49:496-500.
30. Thompson PD, Tsongalis GJ, Ordovas JM, Seip RL, Bilbie C, Miles M, Zoeller R, Visich P, Gordon P, Angelopoulos TJ, Pescatello L, Moyna N: Angiotensin-converting enzyme genotype and adherence to aerobic exercise training. Prev Cardiol 2006;9:21-24.
31. Berentzen T, Dalgaard LT, Petersen L, Pedersen O, Sørensen TI: Interactions between physical activity and variants of the genes encoding uncoupling proteins-and -3 in relation to body weight changes during a 10-y follow-up. Int J Obes (Lond) 2005;29:93-99.
32. Tworoger SS, Chubak J, Aiello EJ, Yasui Y, Ulrich CM, Farin FM, Stapleton PL, Irwin ML, Potter JD, Schwartz RS, McTiernan A: The effect of CYP19 and COMT polymorphisms on exercise-induced fat loss in postmenopausal women. Obes Res 2004;12:972-981.
33. Franks PW, Luan J, Browne PO, Harding AH, O'Rahilly S, Chatterjee VK, Wareham NJ: Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level? Metabolism 2004;53:11-16.
34. Walston J, Andersen RE, Seibert M, Hilfiker H, Beamer B, Blumenthal J, Poehlman ET: Arg64 beta3-adrenoceptor variant and the components of energy expenditure. Obes Res 2003;11:509-511.
35. Hittel DS, Kraus WE, Hoffman EP: Skeletal muscle dictates the fibrinolytic state after exercise training in overweight men with characteristics of metabolic syndrome. J Physiol 2003;548:401-410.
36. Marti A, Corbalán MS, Martínez-Gonzalez MA, Martinez JA: TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle. Diabetes Obes Metab 2002;4:428-430.
37. Kahara T, Takamura T, Hayakawa T, Nagai Y, Yamaguchi H, Katsuki T, Katsuki K, Katsuki M, Kobayashi K: Prediction of exercise-mediated changes in metabolic markers by gene polymorphism. Diabetes Res Clin Pract 2002;57:105-110.
38. Poston WS, Haddock CK, Spertus J, Catanese DM, Pavlik VN, Hyman DJ, Hanis CL, Forevt JP: Physical activity does not mitigate G-protein-related genetic risk for obesity in individuals of African descent. Eat Weight Disord 2002;7:68-71.
39. Moore GE, Shuldiner AR, Zmuda JM, Ferrell RE, McCole SD, Hagberg JM: Obesity gene variant and elite endurance performance. Metabolism 2001;50: 1391-1392.
40. Chagnon YC, Rice T, Pérusse L, Borecki IB, Ho-Kim MA, Lacaille M, Paré C, Bouchard L, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C: HERITAGE Family Study. Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE. J Appl Physiol 2001;90:1777-1787.
41. Otabe S, Clement K, Dina C, Pelloux V, Guy-Grand B, Froguel P, Vasseur F: A genetic variation in the 5- flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity. Diabetologia 2000;43:245-249.
42. Feitosa MF, Rice T, Nirmala A, Rao DC: Major gene effect on body mass index: the role of energy intake and energy expenditure. Hum Biol 2000;72:781-799.
43. Rice T, Hong Y, Pérusse L, Després JP, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC: Total body fat and abdominal visceral fat response to exercise training in the HERITAGE Family Study: evidence for major locus but no multifactorial effects. Metabolism 1999;48:1278-1286.
44. Boer JM, Kuivenhoven JA, Feskens EJ, Schouten EG, Havekes LM, Seidell JC, Kastelein JJ, Kromhout D: Physical activity modulates the effect of a lipoprotein lipase mutation (D9N) on plasma lipids and lipoproteins. Clin Genet 1999;56:158-163.
45. Samaras K, Kelly PJ, Chiano MN, Spector TD, Campbell LV: Genetic and environmental influences on total-body and central abdominal fat: the effect of physical activity in female twins. Ann Intern Med 1999;130:873-882.
46. Meirhaeghe A, Helbecque N, Cottel D, Amouyel P: Beta2-adrenoceptor gene polymorphism, body weight, and physical activity. Lancet 1999;353:896.
47. Bouchard C, Tremblay A: Genetic effects in human energy expenditure components. Int J Obes 1990; 14(suppl 1):49-55; discussion 55-58.
48. Yoshida T, Sakane N, Umekawa T, Sakai M, Takahashi T, Kondo M: Mutation of beta 3-adrenergic- receptor gene and response to treatment of obesity. Lancet 1995;346:1433-1434.
49. Ortega-Alonso A, Sipilä S, Kujala UM, Kaprio J, Rantanen T: Body fat and mobility are explained by common genetic and environmental influences in older women. Obesity (Silver Spring) 2008;16:1616-1621.
50. Rampersaud E, Mitchell BD, Pollin TI, Fu M, Shen H, O'Connell JR, Ducharme JL, Hines S, Sack P, Naglieri R, Shuldiner AR, Snitker S: Physical activity and the association of common FTO gene variants with body mass index and obesity. Arch Intern Med 2008;168:1791-1797.
51. Franks PW, Rolandsson O, Debenham SL, Fawcett KA, Payne F, Dina C, Froguel P, Mohlke KL, Willer C, Olsson T, Wareham NJ, Hallmans G, Barroso I, Sandhu MS: Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations. Diabetologia 2008;51:458-463.
52. Dina C, Meyre D, Gallina S, Durand E, Korner A, Jacobson P, Carlsson LM, Kiess W, Vatin V, Lecoeur C, Delplanque J, Vaillant E, Pattou F, Ruiz J, Weill J, Levy-Marchal C, Horber F, Potoczna N, Hercberg S, Le Stunff C, Bougneres P, Kovacs P, Marre M, Balkau B, Cauchi S, Chevre JC, Froguel P: Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007;39:724-726.
53. Franks PW, Jablonski KA, Delahanty LM, McAteer JB, Kahn SE, Knowler WC, Florez JC: Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program. Diabetologia 2008;51:2214-2223.
54. Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CNA: An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 2008;359:2558-2566.
55. Jonsson A, Franks PW: Obesity, FTO gene variant, and energy intake in children. N Engl J Med 2009;360:1571-1572.
56. Wong MY, Day NE, Luan JA, Chan KP, Wareham NJ: The detection of gene-environment interaction for continuous traits: should we deal with measurement error by bigger studies or better measurement? Int J Epidemiol 2003;32:51-57.
57. Brito EC, Franks PW: Commentary on viewpoint: perspective on the future use of genomics in exercise prescription. J Appl Physiol 2008;104:1248.
58. Church TS, Earnest CP, Skinner JS, Blair SN: Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure: a randomized controlled trial. JAMA 2007;297: 2081-2091.
59. Franks PW: Muscling in on the genetics of quantitative disease traits. J Appl Physiol 2007;103:1111-1112.
60. Goran MI, Poehlman ET: Endurance training does not enhance total energy expenditure in healthy elderly persons. Am J Physiol 1992;263:E950-E957.
61. Jonsson A, Renström F, Lyssenko V, Brito EC, Isomaa B, Berglund G, Nilsson PM, Groop L, Franks PW: Assessing the interaction between FTO variation (rs9939609) and physical activity on obesity in 15,931 Swedish and 2,511 Finnish adults. Diabetologia 2009;52:1334-1338.