Total body fat and abdominal visceral fat response to exercise training in the HERITAGE Family Study: Evidence for major locus but no multifactorial effects

Metabolism: Clinical and Experimental

Volumn 48, Issue 10, 1999, Pages 1278-1286

  Rice, T ^a   Hong, Y ^b   Perusse L ^b   Despres J P ^b   Gagnon, J ^b   Leon, A S ^b   Skinner, J S ^b   Wilmore, J H ^b   Bouchard, C ^b   Rao, D C ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TISSUE; ADULT; ARTICLE; BODY FAT; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORRELATION FUNCTION; EXERCISE; FAMILY STUDY; FEMALE; GENE LOCUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIFACTORIAL INHERITANCE; PRIORITY JOURNAL; SEGREGATION ANALYSIS; VISCERA;

EID: 13044257707     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(99)90268-8     Document Type: Article

References (49)

1. Lapidus L, Bengtsson C, Larsson B, et al: Distribution of adipose tissue and risk of cardiovascular disease and death: A 12-year follow-up of participants in the population study of women in Gothenburg, Sweden. BMJ 289:1257-1261, 1984
2. Ohlson LO, Larsson B, Svardsudd K, et al: The influence of body fat distribution on the incidence of diabetes mellitus: 13.5 years of follow-up of the subjects in the Study of Men Born in 1913. Diabetes 34:1055-1058, 1985
3. Lundgren H, Bengtsson C, Blohmé G, et al: Adiposity and adipose tissue distribution in relation to incidence of diabetes in women: Results from a prospective population study in Gothenburg, Sweden. Int J Obes 13:413-423, 1989
4. Larsson B, Svärdsudd K, Welin L, et al: Abdominal adipose tissue distribution, obesity and risk of cardiovascular disease and death: 13 year follow up of subjects in the Study of Men Born in 1913. BMJ 288:1401-1404, 1984
5. Després JP, Moorjani S, Ferland M, et al: Adipose tissue distribution and plasma lipoprotein levels in obese women: Importance of intra-abdominal fat. Arteriosclerosis 9:203-210, 1989
6. Fujioka S, Matsuzawa Y, Tokunaga K, et al: Improvement of glucose and lipid metabolism associated with selective reduction of intra-abdominal visceral fat in premenopausal women with visceral fat obesity. Int J Obes 15:853-859, 1991
7. Rissanen J, Hudson R, Ross R: Visceral adiposity, androgens, and plasma lipids in obese men. Metabolism 43:1318-1323, 1994
8. Saris WHM: Exercise with or without dietary restriction and obesity treatment. Int J Obes 19:S113-S116, 1995 (suppl 4)
9. Weinsier RL, Hunter GR, Heini AF, et al: The etiology of obesity: Relative contribution of metabolic factors, diet, and physical activity. Am J Med 105:145-150, 1998
10. Bouchard C: Individual differences in the response to regular exercise. Int J Obes 19:S5-S8, 1995 (suppl 4)
11. Bouchard C, Tremblay A, Després JP, et al: The response to exercise with constant energy intake in identical twins. Obes Res 2:400-410, 1994
12. Bouchard C, Leon AS, Rao DC, et al: The HERITAGE Family Study: Aims, design and measurement protocol. Med Sci Sports Exerc 276:721-729, 1995
13. Wilmore JH, Stanforth PR, Domenick MA, et al: Reproducibility of anthropometric and body composition measurements: The HERITAGE Family Study. Int J Obes 21:297-303, 1997
14. Wilmore JH, Després JP, Stanforth PR, et al: Alterations in body mass and composition consequent to 20 weeks of endurance exercise training: The HERITAGE Family Study. Am J Clin Nutr (in press)
15. Willett WC, Sampson L, Stampfer MJ, et al: Reproducibility and validity of a semi-quantitative food frequency questionnaire. Am J Epidemiol 122:51-65, 1985
16. Peters JR, Brekke MJ, Quiter ES, et al: Eating pattern assessment tool: A simple instrument for assessing dietary fat. J Am Diet Assoc 94:1008-1013, 1994
17. Sjöström L, Kvist H, Cederblad A, et al: Determination of the total adipose tissue volume in women by computed tomography: Comparison with 40K and tritium techniques. Am J Physiol 250:736-745, 1986
18. Behnke AR, Wilmore JH: Evaluation and Regulation of Body Build and Composition. Englewood Cliffs, NJ, Prentice-Hall, 1974, pp 21-27
19. Wilmore JH: A simplified method for determination of residual lung volume. J Appl Physiol 27:96-100, 1969
20. Wilmore JH, Vodak PA, Parr RB, et al: Further simplification of a method for determining residual lung volume. Med Sci Sports 12:216-128, 1980
21. Meneely GR, Kaltreider NL: The volume of the lung determined by helium dilution: Description of the method and comparison with other procedures. J Clin Invest 28:129-139, 1949
22. Motley HL: Comparison of simple helium closed with the oxygen open-circuit method for measuring residual air. Am Rev Tuberc Pulm Dis 76:601-615, 1957
23. Rice T, Després JP, Daw EW, et al: Familial resemblance for abdominal visceral fat: The HERITAGE Family Study. Int J Obes 21:1024-1031, 1997
24. Province MA, Rao DC: General purpose model and a computer program for combined segregation and path analysis (SEGPATH): Automatically creating computer programs from symbolic language model specifications. Genet Epidemiol 12:203-219, 1995
25. MacLean CJ, Morton NE, Elston RC, et al: Skewness in commingled distributions. Biometrics 32:695-699, 1976
26. Morton NE, Rao DC, Lalouel JM: Methods in Genetic Epidemiology. Basel, Switzerland, Karger, 1983
27. Akaike H: A new look at the statistical model identification. IEEE Trans Automat Control 29:716-723, 1974
28. Lalouel JM, Rao DC, Morton NE, et al: A unified model for complex segregation analysis. Am J Hum Genet 35:816-826, 1983
29. Lalouel JM, Morton NE: Complex segregation analysis with pointers. Hum Hered 31:312-321, 1981
30. Bray GA: Historical framework for the development of ideas about obesity, in Bray GA, Bouchard C, James WPT (eds): Handbook of Obesity. New York, NY, Dekker, 1998, pp 31-40
31. National Institutes of Health: The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Bethesda, MD, National Institutes of Health, Publication No. 98-4080, Nov 1997
32. Bouchard C, Rice T, Lemieux S, et al: Major gene for abdominal visceral fat area in the Québec Family Study. Int J Obes 20:420-427, 1996
33. Pérusse L, Després JP, Lemieux S, et al: Familial aggregation of abdominal visceral fat level: Results from the Québec Family Study. Metabolism 45:378-382, 1996
34. Rice T, Després JP, Pérusse L, et al: Segregation analysis of abdominal visceral fat: The HERITAGE Family Study. Obes Res 5:417-424, 1997
35. Rice T, Borecki IB, Bouchard C, et al: Segregation analysis of fat mass and other body composition measures derived from underwater weighing. Am J Hum Genet 52:967-973, 1993
36. Comuzzie AG, Blangero J, Mahaney MC, et al: Major gene with sex-specific effects influences fat mass in Mexican Americans. Genet Epidemiol 12:475-488, 1995
37. Arner P: Impact of exercise on adipose tissue metabolism in humans. Int J Obes 19:S18-S21, 1995 (suppl 4)
38. Chagnon YC, Pérusse L, Bouchard C: The human obesity gene map: The 1997 update. Obes Res 6:76-92, 1998
39. Pouliot MC, Després JP, Dionne FT, et al: ApoB-100 gene EcoRI polymorphism. Relations to plasma lipoprotein changes associated with abdominal visceral obesity. Arterioscler Thromb 14:527-533, 1994
40. Buemann B, Vohl MC, Chagnon M, et al: Abdominal visceral fat is associated with a BclI restriction fragment length polymorphism at the glucocorticoid receptor gene locus. Obes Res 5:186-192, 1997
41. Yamada K, Yuan X, Ishiyama S, et al: Association between Ala54Thr substitution of the fatty acid-binding protein 2 gene with insulin resistance and intra-abdominal fat thickness in Japanese men. Diabetologia 40:706-710, 1997
42. Sakane N, Yoshida T, Umekawa T, et al: Beta 3-adrenergic-receptor polymorphism: A genetic marker for visceral fat obesity and the insulin resistance syndrome. Diabetologia 40:200-204, 1997
43. Kim-Motoyama H, Yasuda K, Yamaguchi T, et al: A mutation of the β3-adrenergic receptor is associated with visceral obesity but decreased serum triglyceride. Diabetologia 40:469-472, 1997
44. Gagnon J, Mauriège P, Roy S, et al: The Trp64Arg mutation of the b3 adrenergic receptor gene has no effect on obesity phenotypes in the Québec Family Study and the Swedish Obese Subjects cohorts. J Clin Invest 98:2086-2093, 1996
45. Oppert JM, Vohl MC, Chagnon M, et al: DNA polymorphism in the uncoupling protein (UCP) gene and human body fat. Int J Obes 18:526-531, 1994
46. Fumeron F, Durack-Bown I, Betoulle D, et al: Polymorphisms of uncoupling protein (UCP) and β3-adrenoreceptor genes in obese people submitted to a low calorie diet. Int J Obes 20:1051-1054, 1997
47. Oksanen L, Öhman M, Heiman M, et al: Markers for the gene ob and serum leptin levels in human morbid obesity. Hum Genet 99:559-564, 1997
48. Clément K, Vaisse C, Manning BSJ, et al: Genetic variation in the β3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med 333:352-354, 1995
49. 64Arg mutation in the β3-adrenergic receptor gene and obesity in Japanese men: A longitudinal analysis. J Clin Endocrinol Metab 82:1284-1287, 1997