1,5-Benzodiazepines: Part XIII. Substituted 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5-amines and 4H-imidazo[1,2-a][1,5]benzodiazepin-5-amines as analgesic, anti-inflammatory and/or antipyretic agents with low acute toxicity

European Journal of Medicinal Chemistry

Volumn 37, Issue 12, 2002, Pages 933-944

  Grossi, Giancarlo ^a   Di Braccio, Mario ^a   Roma, Giorgio ^a   Ballabeni, Vigilio ^b   Tognolini, Massimiliano ^b   Calcina, Francesco ^b   Barocelli, Elisabetta ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

1,5 Benzodiazepine tricyclic derivatives; Acute toxicity; Analgesic; Anti inflammatory; Antipyretic; Gastrolesivity

Indexed keywords

4 (DIBUTYLAMINO) 1,3 DIHYDRO 2H 1,5 BENZODIAZEPIN 2 ONE; 4 [(2,2 DIMETHOXYETHYL)AMINO] 1,3 DIHYDRO 2H 1,5 DIBENZODIAZEPIN 2 ONE; 5 (1 PIPERIDINYL) 4H IMIDAZO[1,2 A][1,5]BENZODIAZEPINE; 5 MORPHOLINO 1 PHENYL 4H[1,2,4]TRIAZOLO[4,3 A][1,5]BENZODIAZEPINE; 5 MORPHOLINO 4H IMIDAZO[1,2 A][1,5]BENZODIAZEPINE; AMINE; ANTIINFLAMMATORY AGENT; ANTIPYRETIC ANALGESIC AGENT; BENZODIAZEPINE DERIVATIVE; DIAZEPINE DERIVATIVE; N,N DIBUTYL 4 (1 PIPERIDINYL) 4H[1,2,4]TRIAZOLO[4,3 A][1,5]BENZODIAZEPIN 5 AMINE; N,N DIBUTYL 4 MORPHOLINO 4H[1,2,4]TRIAZOLO[4,3 A][1,5]BENZODIAZEPIN 5 AMINE; N,N DIETHYL 4 (1 PIPERIDINYL) 4H[1,2,4]TRIAZOL[4,3 A][1,5]BENZODIAZEPIN 5 AMINE; N,N DIETHYL 4 (4 METHYL 1 PIPERAZINYL) 4H[1,2,4]TRIAZOLO[4,3 A][1,5]BENZODIAZEPIN 5 AMINE; N,N DIETHYL 4 MORPHOLINO 4H[1,2,4]TRIAZOLO[4,3 A][1,5]BENZODIAZEPIN 5 AMINE; N,N DIMETHYL 1 PHENYL 4 (1 PIPERIDINYL) 4H[1,2,4]TRIAZOLO[4,3 A][1,5]BENZODIAZEPIN 5 AMINE; N,N DIMETHYL 1 PHENYL 4 (1 PYRROLIDINYL) 4H[1,2,4]TRIAZOLO[4,3 A][1,5]BENZODIAZEPIN 5 AMINE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIPYRETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; EDEMA; FEVER; MALE; NONHUMAN; PAIN; RAT; ULCEROGENESIS; WRITHING TEST;

ANALGESICS; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZODIAZEPINES; DRUG DESIGN; FEVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; RATS; RATS, WISTAR; STOMACH; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036952880     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(02)01400-9     Document Type: Article

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