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Volumn 20, Issue 22, 2009, Pages 2594-2599

Enzyme-mediated synthesis of EEHP and EMHP, useful pharmaceutical intermediates of PPAR agonists

Author keywords

[No Author keywords available]

Indexed keywords

CHYMOTRYPSIN A; ESTER DERIVATIVE; ETHYL 2 ETHOXY 3 (4 HYDROXYPHENYL)PROPANOIC ACID; ETHYL 2 METHOXY 3 (4 HYDROXYPHENYL)PROPANOIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PROPIONIC ACID DERIVATIVE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

EID: 72049098523     PISSN: 09574166     EISSN: 1362511X     Source Type: Journal    
DOI: 10.1016/j.tetasy.2009.10.013     Document Type: Article
Times cited : (14)

References (27)
  • 2
    • 72049118377 scopus 로고    scopus 로고
    • PCT Appl. WO 99/62872, to Astra
    • Anderson, K. PCT Appl. WO 99/62872 (1999 to Astra).
    • (1999)
    • Anderson, K.1
  • 4
    • 72049085723 scopus 로고    scopus 로고
    • note
    • ® by AstraZeneca, but its production was stopped in 2006, because the benefits were not worth the risks.
  • 6
    • 72049095503 scopus 로고    scopus 로고
    • For an approach based on the diazotisation of l-tyrosine derivatives, followed by O-alkylation see:, PCT Appl. WO 02/24625
    • For an approach based on the diazotisation of l-tyrosine derivatives, followed by O-alkylation see: Potlapally, R. K.; Siripragada, M. R.; Kotra, N. M.; Sirisilla, R.; Mamillapalli, R. S.; PCT Appl. WO 02/24625.
    • Potlapally, R.K.1    Siripragada, M.R.2    Kotra, N.M.3    Sirisilla, R.4    Mamillapalli, R.S.5
  • 12
    • 72049132819 scopus 로고    scopus 로고
    • For an asymmetric synthesis of 1 by catalytic reduction of α-ethoxycinnamic acid, see: Woltering, M.; Bunlakasnanusorn, T.; Gerlach, A. PCT Appl. US 2007/0149804.
    • For an asymmetric synthesis of 1 by catalytic reduction of α-ethoxycinnamic acid, see: Woltering, M.; Bunlakasnanusorn, T.; Gerlach, A. PCT Appl. US 2007/0149804.
  • 14
    • 71849118073 scopus 로고    scopus 로고
    • Brenna, E.; Fuganti, C.; Gatti, F. C.; Parmeggiani, F. Tetrahedron: Asymmetry 2009, 20, in press. doi:10.1016/j.tetasy.2009.09.024.
    • Brenna, E.; Fuganti, C.; Gatti, F. C.; Parmeggiani, F. Tetrahedron: Asymmetry 2009, 20, in press. doi:10.1016/j.tetasy.2009.09.024.
  • 19
    • 72049090311 scopus 로고    scopus 로고
    • Barot, V. K. G.; Kothari, H. M.; Lohray, B. B.; Lohray, V. B. PCT Appl. WO 2005/019152.
    • Barot, V. K. G.; Kothari, H. M.; Lohray, B. B.; Lohray, V. B. PCT Appl. WO 2005/019152.
  • 21
    • 72049120869 scopus 로고    scopus 로고
    • note
    • A similar PS-lipase-mediated resolution has been already carried out on the methyl ester of 5, Ref. 9b.
  • 26
    • 72049121805 scopus 로고    scopus 로고
    • note
    • Ref. 7c describes the α-CT-catalysed hydrolysis of racemic 1 at pH 7.0, which furnished (S)-1 with 34% ee and after a conversion of 84%.
  • 27
    • 72049094203 scopus 로고    scopus 로고
    • note
    • This sample was provided by AstraZeneca.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.