-
1
-
-
34548182594
-
-
For a review see:
-
For a review see:. Balakumar P., Rose M., Ganti S.S., Krishan P., and Singh M. Pharm. Res. 56 (2007) 91
-
(2007)
Pharm. Res.
, vol.56
, pp. 91
-
-
Balakumar, P.1
Rose, M.2
Ganti, S.S.3
Krishan, P.4
Singh, M.5
-
2
-
-
72049118377
-
-
PCT Appl. WO 99/62872, to Astra
-
Anderson, K. PCT Appl. WO 99/62872 (1999 to Astra).
-
(1999)
-
-
Anderson, K.1
-
3
-
-
9644252788
-
-
Martin J.A., Brooks D.A., Prieto L., Gonzalez R., Torrado A., Rojo I., Lopez de Uralde B., Lamas C., Ferrito M., Martin-Ortega M.D., Agejas J., Parra F., Rizzo J.R., Rhodes G.A., Robey R.L., Alt C.A., Wendel S.R., Zhang T.Y., Reifel-Miller A., Montrose-Rafidazeh C., Brozinik J.T., Hawkins E., Misener E.A., Briere D.A., Ardecky R., Fraser J.D., and Warshawsky A.M. Bioorg. Med. Chem. Lett. 15 (2005) 51-55
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 51-55
-
-
Martin, J.A.1
Brooks, D.A.2
Prieto, L.3
Gonzalez, R.4
Torrado, A.5
Rojo, I.6
Lopez de Uralde, B.7
Lamas, C.8
Ferrito, M.9
Martin-Ortega, M.D.10
Agejas, J.11
Parra, F.12
Rizzo, J.R.13
Rhodes, G.A.14
Robey, R.L.15
Alt, C.A.16
Wendel, S.R.17
Zhang, T.Y.18
Reifel-Miller, A.19
Montrose-Rafidazeh, C.20
Brozinik, J.T.21
Hawkins, E.22
Misener, E.A.23
Briere, D.A.24
Ardecky, R.25
Fraser, J.D.26
Warshawsky, A.M.27
more..
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4
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72049085723
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note
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® by AstraZeneca, but its production was stopped in 2006, because the benefits were not worth the risks.
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5
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39849086207
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Parmenon C., Guillard J., Caignard D.-H., Hennuyer N., Staels B., Audinot-Bouchez V., Boutin J.A., Dacquet C., Ktorza A., and Viaud-Massuard M.-C. Bioorg. Med. Chem. Lett. 18 (2008) 1617
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 1617
-
-
Parmenon, C.1
Guillard, J.2
Caignard, D.-H.3
Hennuyer, N.4
Staels, B.5
Audinot-Bouchez, V.6
Boutin, J.A.7
Dacquet, C.8
Ktorza, A.9
Viaud-Massuard, M.-C.10
-
6
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72049095503
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For an approach based on the diazotisation of l-tyrosine derivatives, followed by O-alkylation see:, PCT Appl. WO 02/24625
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For an approach based on the diazotisation of l-tyrosine derivatives, followed by O-alkylation see: Potlapally, R. K.; Siripragada, M. R.; Kotra, N. M.; Sirisilla, R.; Mamillapalli, R. S.; PCT Appl. WO 02/24625.
-
-
-
Potlapally, R.K.1
Siripragada, M.R.2
Kotra, N.M.3
Sirisilla, R.4
Mamillapalli, R.S.5
-
7
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72049114640
-
-
PCT Appl. WO 03/027084
-
Potlapally, R. K.; Siripragada, M. R.; Mamillapalli, R. S.; Gaddam, O. R.; Jangaigar, T. R.; Velagala, V. R. M. K. R.; PCT Appl. WO 03/027084.
-
-
-
Potlapally, R.K.1
Siripragada, M.R.2
Mamillapalli, R.S.3
Gaddam, O.R.4
Jangaigar, T.R.5
Velagala, V.R.M.K.R.6
-
8
-
-
72049093681
-
-
Zeng Q.L., Wang H.Q., Liu Z.R., Li B.G., and Zhao Y.F. Amino Acids 33 (2007) 536-541
-
(2007)
Amino Acids
, vol.33
, pp. 536-541
-
-
Zeng, Q.L.1
Wang, H.Q.2
Liu, Z.R.3
Li, B.G.4
Zhao, Y.F.5
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9
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0037283982
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-
For an approach based on enzymatic/chemical resolution of derivatives of 1 or 2, see:
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For an approach based on enzymatic/chemical resolution of derivatives of 1 or 2, see:. Deussen H.-J., Zundel M., Valdois M., Lehmann S.V., Weil V., Hjort C.M., Østergaard P.R., Marcussen E., and Ebdrup S. Org. Process Res. Dev. 7 (2003) 82-88
-
(2003)
Org. Process Res. Dev.
, vol.7
, pp. 82-88
-
-
Deussen, H.-J.1
Zundel, M.2
Valdois, M.3
Lehmann, S.V.4
Weil, V.5
Hjort, C.M.6
Østergaard, P.R.7
Marcussen, E.8
Ebdrup, S.9
-
12
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72049132819
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For an asymmetric synthesis of 1 by catalytic reduction of α-ethoxycinnamic acid, see: Woltering, M.; Bunlakasnanusorn, T.; Gerlach, A. PCT Appl. US 2007/0149804.
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For an asymmetric synthesis of 1 by catalytic reduction of α-ethoxycinnamic acid, see: Woltering, M.; Bunlakasnanusorn, T.; Gerlach, A. PCT Appl. US 2007/0149804.
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-
-
-
13
-
-
19544375431
-
-
Houpis I.N., Patterson L.E., Alt C.A., Zhang T.Y., and Haurez M. Org. Lett. 7 (2005) 1947-1950
-
(2005)
Org. Lett.
, vol.7
, pp. 1947-1950
-
-
Houpis, I.N.1
Patterson, L.E.2
Alt, C.A.3
Zhang, T.Y.4
Haurez, M.5
-
14
-
-
71849118073
-
-
Brenna, E.; Fuganti, C.; Gatti, F. C.; Parmeggiani, F. Tetrahedron: Asymmetry 2009, 20, in press. doi:10.1016/j.tetasy.2009.09.024.
-
Brenna, E.; Fuganti, C.; Gatti, F. C.; Parmeggiani, F. Tetrahedron: Asymmetry 2009, 20, in press. doi:10.1016/j.tetasy.2009.09.024.
-
-
-
-
15
-
-
0032581676
-
-
Wang Z., La B., Fortunak J.M., Meng X.-J., and Kabalka G.W. Tetrahedron Lett. 39 (1998) 5501-5504
-
(1998)
Tetrahedron Lett.
, vol.39
, pp. 5501-5504
-
-
Wang, Z.1
La, B.2
Fortunak, J.M.3
Meng, X.-J.4
Kabalka, G.W.5
-
18
-
-
0027080917
-
-
Gentile A., Giordano C., Fuganti C., Ghirotto L., and Servi S. J. Org. Chem. 57 (1992) 6635-6637
-
(1992)
J. Org. Chem.
, vol.57
, pp. 6635-6637
-
-
Gentile, A.1
Giordano, C.2
Fuganti, C.3
Ghirotto, L.4
Servi, S.5
-
19
-
-
72049090311
-
-
Barot, V. K. G.; Kothari, H. M.; Lohray, B. B.; Lohray, V. B. PCT Appl. WO 2005/019152.
-
Barot, V. K. G.; Kothari, H. M.; Lohray, B. B.; Lohray, V. B. PCT Appl. WO 2005/019152.
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-
-
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21
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72049120869
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note
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A similar PS-lipase-mediated resolution has been already carried out on the methyl ester of 5, Ref. 9b.
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22
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0034354383
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Yamano T., Kikumoto F., Yamamoto S., Miwa K., Kawada M., Ito T., Ikemoto T., Tomimatsu K., and Mizuno Y. Chem. Lett. 29 (2000) 448-450
-
(2000)
Chem. Lett.
, vol.29
, pp. 448-450
-
-
Yamano, T.1
Kikumoto, F.2
Yamamoto, S.3
Miwa, K.4
Kawada, M.5
Ito, T.6
Ikemoto, T.7
Tomimatsu, K.8
Mizuno, Y.9
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25
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20344405982
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Aikins J.A., Haurez M., Rizzo J.R., Van Hoeck J.-P., Brione W., Kastemont J.-P., Stevens C., Lemair X., Stephenson G.A., Marlot E., Forst M., and Houpis I.N. J. Org. Chem. 70 (2005) 4695-4705
-
(2005)
J. Org. Chem.
, vol.70
, pp. 4695-4705
-
-
Aikins, J.A.1
Haurez, M.2
Rizzo, J.R.3
Van Hoeck, J.-P.4
Brione, W.5
Kastemont, J.-P.6
Stevens, C.7
Lemair, X.8
Stephenson, G.A.9
Marlot, E.10
Forst, M.11
Houpis, I.N.12
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26
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72049121805
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note
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Ref. 7c describes the α-CT-catalysed hydrolysis of racemic 1 at pH 7.0, which furnished (S)-1 with 34% ee and after a conversion of 84%.
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27
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72049094203
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note
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This sample was provided by AstraZeneca.
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