Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport

Toxicology in Vitro

Volumn 24, Issue 1, 2010, Pages 297-309

  Wolf, Kristina K ^a   Vora, Sapana ^a   Webster, Lindsey O ^b   Generaux, Grant T ^b   Polli, Joseph W ^b   Brouwer, Kim L R ^a  

^a UNC Hamner Institute for Drug Safety Sciences   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Hepatobiliary transport; Hepatotoxicity; High throughput screening; In vitro models; Sandwich cultured hepatocytes; Taurocholate

Indexed keywords

AMPICILLIN; AZLOCILLIN; BIFONAZOLE; BILE ACID; CARBAMAZEPINE; CARBENICILLIN; CEFALEXIN; CEFTRIAXONE; CEFUROXIME; CLOTRIMAZOLE; CLOXACILLIN; CYCLOSPORIN A; IBUPROFEN; INDOMETACIN; ISONIAZID; MENADIONE; MINOCYCLINE; NAFCILLIN; OXACILLIN; PENTAMIDINE; PHENOBARBITAL; PHENYTOIN; PIOGLITAZONE; PIROXICAM; PREDNISONE; RIFAMPICIN; TAUROCHOLIC ACID; TICARCILLIN; TROGLITAZONE; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; BILE FLOW; CYTOTOXICITY; DRUG DETERMINATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CULTURE; LIVER TOXICITY; MALE; NONHUMAN; RAT; TOXICITY TESTING;

ANIMALS; ANTI-INFECTIVE AGENTS; BILE; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT, ACTIVE; CELLS, CULTURED; CHOLAGOGUES AND CHOLERETICS; CYCLOSPORINE; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HEPATOCYTES; HUMANS; HYPOGLYCEMIC AGENTS; IMMUNOSUPPRESSIVE AGENTS; LIVER; MALE; RATS; RATS, WISTAR; TAUROCHOLIC ACID;

RATTUS;

EID: 72049095849     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.08.009     Document Type: Article

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