Pyrazole derived from (+)-3-carene; a novel potent, selective scaffold for sphingosine-1-phosphate (S1P1) receptor agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 1, 2010, Pages 35-37

  Zécri, Frédéric J ^a   Albert, Rainer ^b   Landrum, Gregory ^a   Hinterding, Klaus ^c   Cooke, Nigel G ^a   Guerini, Danilo ^a   Streiff, Markus ^a   Bruns, Christian ^a   Nuesslein Hildesheim, Barbara ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Gerbergässlein 8 III   (Switzerland)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Carene; Pharmacophore model; S1P1 agonist

Indexed keywords

3 [2 (3 TRIFLUOROMETHYL 4 BIPHENYLYL)BENZO[B]THIEN 5 YLMETHYLAMINO]PROPIONIC ACID; 5 (4 PHENYL 5 TRIFLUOROMETHYL 2 THIENYL) 3 (3 TRIFLUOROMETHYLPHENYL) 1,2,4 OXADIAZOLE; FINGOLIMOD; PYRAZOLE DERIVATIVE; SPHINGOSINE 1 PHOSPHATE RECEPTOR;

ARTICLE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

HIGH-THROUGHPUT SCREENING ASSAYS; HYDROGEN BONDING; MONOTERPENES; PYRAZOLES; RECEPTORS, LYSOSPHINGOLIPID; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72049095045     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.11.045     Document Type: Article

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