Prompt lithiation of 1-dimethylsulfamoylthymine used for the synthesis of 1-allyloxymethyl-6-(α,2,6-trifluorobenzyl)thymine

Synthesis

Volumn , Issue 21, 2009, Pages 3589-3592

  Loksha, Yasser M ^a   Pedersen, Erik B ^a   Bond, Andrew D ^a   La Colla, Paolo ^b   Secci, Barbara ^b   Loddo, Roberta ^b  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b Virologia Generale e Biotecnologie Microbiche   (Italy)

Author keywords

Antiviral agents; Heterocycles; HIV; Medicinal chemistry; Sulfonamides

Indexed keywords

ANTIVIRAL AGENTS; DIFLUOROPHENYL; HETEROCYCLES; INTERMEDIATE PRODUCT; LITHIATION; LITHIATION REACTION; MEDICINAL CHEMISTRY;

AMIDES; CHLORINE COMPOUNDS; FLUORINE CONTAINING POLYMERS; METHANE; MINERALOGY; OXYGEN; SELF ASSEMBLY; SILANES; SULFUR COMPOUNDS; VIRUSES;

X RAY CRYSTALLOGRAPHY;

1 ALLYLOXYMETHYL 6 [(2,6 DIFLUOROPHENYL)FLUOROMETHYL] 5 METHYLPYRIMIDINE 2,4(1H,3H) DIONE; 1 DIMETHYLSULFAMOYLTHYMINE; ALCOHOL; BENZALDEHYDE DERIVATIVE; CHLORIDE; DIMETHYLSULFAMOYL CHLORIDE; OXYGEN; PYRIMIDINE DERIVATIVE; SULFUR DERIVATIVE; THYMINE; THYMINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; FLUORINATION; HUMAN IMMUNODEFICIENCY VIRUS 1; LITHIATION; POLYMERIZATION; REACTION ANALYSIS; SILYLATION; SULFAMOYLATION; X RAY CRYSTALLOGRAPHY;

EID: 72049090147     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/S-0029-1216978     Document Type: Article

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