Overexpression of the single-stranded DNA-binding protein (SSB) stabilises CAG•CTG triplet repeats in an orientation dependent manner

FEBS Letters

Volumn 584, Issue 1, 2010, Pages 153-158

  Andreoni, Federica ^a   Darmon, Elise ^a   Poon, Wilson C K ^a   Leach, David R F ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

SbcCD; Single stranded DNA binding protein; Trinucleotide repeat instability

Indexed keywords

MRE11 PROTEIN; RAD51 PROTEIN; SINGLE STRANDED DNA BINDING PROTEIN;

ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL STRAIN; BACTERIUM MUTANT; CONTROLLED STUDY; ESCHERICHIA COLI; GENE DELETION; GENE INSERTION; GENE OVEREXPRESSION; GENETIC STABILITY; GENETIC TRANSDUCTION; GENOME SIZE; NONHUMAN; PRIORITY JOURNAL; TRINUCLEOTIDE REPEAT;

DEOXYRIBONUCLEASES; DNA, SINGLE-STRANDED; DNA-BINDING PROTEINS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; EXONUCLEASES; GENOMIC INSTABILITY; SEQUENCE DELETION; TRINUCLEOTIDE REPEATS;

ESCHERICHIA COLI;

EID: 71949125701     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.11.042     Document Type: Article

References (22)

1. Jeffreys A.J., Holloway J.K., Kauppi L., May C.A., Neumann R., Slingsby M.T., and Webb A.J. Meiotic recombination hot spots and human DNA diversity. Philos. Trans. R. Soc. Lond. B Biol. Sci. 359 (2004) 141-152
2. Yant S.R., Wu X., Huang Y., Garrison B., Burgess S.M., and Kay M.A. High-resolution genome-wide mapping of transposon integration in mammals. Mol. Cell Biol. 25 (2005) 2085-2094
3. Durkin S.G., and Glover T.W. Chromosome fragile sites. Annu. Rev. Genet. 41 (2007) 169-192
4. Sinden R.R., Potaman V.N., Oussatcheva E.A., Pearson C.E., Lyubchenko Y.L., and Shlyakhtenko L.S. Triplet repeat DNA structures and human genetic disease: dynamic mutations from dynamic DNA. J. Biosci. 27 (2002) 53-65
5. Sutherland G.R., and Richards R.I. Simple tandem DNA repeats and human genetic disease. Proc. Natl. Acad. Sci. USA 92 (1995) 3636-3641
6. Cummings C.J., and Zoghbi H.Y. Trinucleotide repeats: mechanisms and pathophysiology. Annu. Rev. Genomics Hum. Genet. 1 (2000) 281-328
7. Kovtun I.V., and McMurray C.T. Trinucleotide expansion in haploid germ cells by gap repair. Nat. Genet. 27 (2001) 407-411
8. Kovtun I.V., Liu Y., Bjoras M., Klungland A., Wilson S.H., and McMurray C.T. OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature 447 (2007) 447-452
9. Mirkin S.M. Expandable DNA repeats and human disease. Nature 447 (2007) 932-940
10. Pearson C.E., Nichol Edamura K., and Cleary J.D. Repeat instability: mechanisms of dynamic mutations. Nat. Rev. Genet. 6 (2005) 729-742
11. Gacy A.M., Goellner G., Juranic N., Macura S., and McMurray C.T. Trinucleotide repeats that expand in human disease form hairpin structures in vitro. Cell 81 (1995) 533-540
12. Kunkel T.A. Nucleotide repeats. Slippery DNA and diseases. Nature 365 (1993) 207-208
13. Pearson C.E., Tam M., Wang Y.H., Montgomery S.E., Dar A.C., Cleary J.D., and Nichol K. Slipped-strand DNAs formed by long (CAG)*(CTG) repeats: slipped-out repeats and slip-out junctions. Nucleic Acids Res. 30 (2002) 4534-4547
14. Rosche W.A., Jaworski A., Kang S., Kramer S.F., Larson J.E., Geidroc D.P., Wells R.D., and Sinden R.R. Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli. J. Bacteriol. 178 (1996) 5042-5044
15. Eykelenboom J.K., Blackwood J.K., Okely E., and Leach D.R. SbcCD causes a double-strand break at a DNA palindrome in the Escherichia coli chromosome. Mol. Cell 29 (2008) 644-651
16. Connelly J.C., de Leau E.S., and Leach D.R. DNA cleavage and degradation by the SbcCD protein complex from Escherichia coli. Nucleic Acids Res. 27 (1999) 1039-1046
17. Bzymek M., and Lovett S.T. Evidence for two mechanisms of palindrome-stimulated deletion in Escherichia coli: Single-strand annealing and replication slipped mispairing. Genetics 158 (2001) 527-540
18. Zahra R., Blackwood J.K., Sales J., and Leach D.R. Proofreading and secondary structure processing determine the orientation dependence of CAG x CTG trinucleotide repeat instability in Escherichia coli. Genetics 176 (2007) 27-41
19. Merlin C., McAteer S., and Masters M. Tools for characterization of Escherichia coli genes of unknown function. J. Bacteriol. 184 (2002) 4573-4581
20. Gil D., and Bouche J.P. ColE1-type vectors with fully repressible replication. Gene 105 (1991) 17-22
21. Darmon E., Lopez-Vernaza M.A., Helness A.C., Borking A., Wilson E., Thacker Z., Wardrope L., and Leach D.R. SbcCD regulation and localization in Escherichia coli. J. Bacteriol. 189 (2007) 6686-6694
22. Miret J.J., Pessoa-Brandao L., and Lahue R.S. Instability of CAG and CTG trinucleotide repeats in Saccharomyces cerevisiae. Mol. Cell Biol. 17 (1997) 3382-3387