The role of P-glycoprotein in intestinal transport versus the BBB transport of tetraphenylphosphonium

Molecular Pharmaceutics

Volumn 6, Issue 6, 2009, Pages 1883-1890

  Swed, Avi ^a   Eyal, Sara ^b   Madar, Igal ^c   Zohar Kontante, Hila ^a   Weiss, Lola ^d   Hoffman, Amnon ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b UNIVERSITY OF WASHINGTON   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Absorption; BBB uptake; Caco 2; Dinitrophenol; Distribution; Imaging; Intestinal permeability; MDR; P glycoprotein; P gp knockout mice; TPP; Tumor; Ussing chamber; Verapamil

Indexed keywords

2,4 DINITROPHENOL; CYCLOSPORIN A; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; TETRAPHENYLPHOSPHONIUM; VALSPODAR; VERAPAMIL; VERLUKAST;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG TRANSPORT; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; MALE; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

2,4-DINITROPHENOL; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CACO-2 CELLS; CALCIUM CHANNEL BLOCKERS; CYCLOSPORINE; CYCLOSPORINS; ENZYME INHIBITORS; FEMALE; HUMANS; INTESTINES; LEUKOTRIENE ANTAGONISTS; MICE; MICE, KNOCKOUT; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ONIUM COMPOUNDS; ORGANOPHOSPHORUS COMPOUNDS; P-GLYCOPROTEIN; PROPIONATES; QUINOLINES; RATS; UNCOUPLING AGENTS; VERAPAMIL;

EID: 71949121823     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp900170y     Document Type: Article

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