Iron as a cause of Parkinson disease - a myth or a well established hypothesis?

Parkinsonism and Related Disorders

Volumn 15, Issue SUPPL. 3, 2009, Pages

  Friedman, Andrzej ^a   Galazka Friedman, Jolanta ^b   Koziorowski, Dariusz ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b WARSAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Iron; Oxidative stress; Parkinson disease

Indexed keywords

FERRITIN; IRON;

ARTICLE; BRAIN TISSUE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IRON METABOLISM; NERVE DEGENERATION; OXIDATIVE STRESS; PARKINSON DISEASE; PARKINSONISM; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SPECTROPHOTOMETRY; SUBSTANTIA NIGRA; X RAY FLUORESCENCE;

ANIMALS; APOFERRITINS; HUMANS; IRON; PARKINSON DISEASE; SUBSTANTIA NIGRA;

EID: 71849112978     PISSN: 13538020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1353-8020(09)70817-X     Document Type: Article

References (28)

1. Halliwell B. Oxidation and the central nervous system: some fundamental questions. Acta Neurol Scand 126 (1989) 23-33
2. Gała{ogonek}zka-Friedman J., and Friedman A. Controversies aboutiron in parkinsonian and control substantia nigra. Acta Neurobiol Exp 57 (1997) 210-225
3. Friedman A, Galazka-Friedman J, Bauminger ER. Iron as a trigger of neurodegeneration in Parkinson's disease. In: Handbook of Clinical Neurology, vol. 83, Koller W & Melamed E, eds, Parkinson's disease and related disorders, ISBN 0444519009., Elsevier, Edinburgh 2007; pp. 493-506.
4. Uitti R.J., Rajput A.H., Rozdilsky B., Bickis M., Wollin T., and Yuen W.K. Regional metal concentrations in Parkinson's disease, other chronic neurological disease, and control brains. Can J Neurol Sci 16 (1989) 310-314
5. Loeffler D.A., Connor J.R., Juneau P.I., Snyder B.S., Kanaley L., DeMaggio A.J., et al. Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions. J Neurochem 65 (1995) 710-716
6. Gała{ogonek}zka-Friedman J., Bauminger E.R., Friedman A., Barcikowska M., Hechel D., and Nowik I. Iron in parkinsonian and control substantia nigra-a Mössbauer spectroscopy study. Movement Disorders 11 (1996) 8-16
7. Earle K.M. Studies on Parkinson's disease including x-ray fluorescent spectroscopy of formalin fixed brain tissue. J Neuropathol Exp Neurol 27 (1968) 1-13
8. Bauminger E.R., Barcikowska M., Friedman A., Gała{ogonek}zka-Friedman J., Hechel D., and Nowik I. Does iron play a role in Parkinson's disease?. Hyperfine Interactions 91 (1994) 853-856
9. Sofic E., Riederer P., Heinsen H., Beckmann H., Reynolds G.P., Hebenstreit G., et al. Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain. J Neural Trans 74 (1988) 199-205
10. Zecca L., and Swartz H.M. Total and paramagnetic metals in human substantia nigra and its neuromelanin. J Neural Trans [P-D Sect] 5 (1993) 203-213
11. Hallgren B., and Sourander P. The effect of age on the non-haemin iron the human brain. J Neurochem 3 (1958) 41-51
12. Zecca L., Stroppolo A., Gatti A., Tampellini D., Toscani M., Gallorini M., et al. The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. PNAS 101 (2004) 9843-9848
13. Galazka-Friedman J., Friedman A., and Bauminger E.R. Iron in the brain. Hyperfine Interact 189 (2009) 31-37
14. Riederer P., Sofic E., Rausch W.-D., Schmidt B., Reynolds G.P., Jellinger K., et al. Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains. J Neurochem 52 (1989) 515-520
15. Jellinger K., Kienzel E., Rumpelmair G., Riederer P., Stachelberger H., Ben-Shachar D., et al. Iron-melanin complex in substantia nigra of parkinsonian brains: an X-ray microanalysis. J Neurochem 59 (1992) 1168-1171
16. Hirsch E.C., Brandel J.P., Galle P., Javoy-Agid F., and Agid Y. Iron and aluminium increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis. J Neurochem 56 (1991) 446-451
17. Oakley A.E., Collingwood J.F., Dobson J., Love G., Perrott H.R., Edwardson J.A., et al. Individual dopaminergic neurons show raised iron levels in Parkinson disease. Neurology 68 (2007) 1820-1825
18. Galazka-Friedman J., Bauminger E.R., and Friedman A. Iron in Parkinson's disease - revisited. Hyperfine Interactions 141/142 (2002) 267-271
19. Dexter D.T., Wells F.R., Lees A.J., Agid F., Agid Y., Jenner P., et al. Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease. J Neurochem 52 (1989) 1830-1836
20. Griffiths P.D., and Crossman A.R. Distribution of iron in the basal ganglia and neocortex in postmortem tissue in Parkinson's disease and Alzheimer's disease. Dementia 4 (1993) 61-65
21. Mann V.M., Cooper J.M., Daniel S.E., Srai K., Jenner P., Marsden C.D., et al. Complex I, iron, and ferritin in Parkinson's disease substantia nigra. Ann Neurol 36 (1994) 876-881
22. Galazka-Friedman J., Bauminger E.R., Koziorowski D., and Friedman A. Mössbauer spectroscopy and ELISA studies reveal differences between Parkinson's disease and control substantia nigra. Biochim. Biophys. Acta 1688 (2004) 130-136
23. Koziorowski D., Friedman A., Arosio P., Santambrogio P., and Dziewulska D. ELISA reveals a difference in the structure of substantia nigra ferritin in Parkinson's disease and Incidental Lewy Body compared to control. Park Rel Disord 13 (2007) 214-218
24. Connor J.R., Snyder B.S., Arosio P., Loeffler D.A., and LeWitt P. A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains. J Neurochem 65 (1995) 717-724
25. Harrison P.M., and Arosio P. The ferritins: molecular properties, iron storage function and cellular regulation. Biochim Biophys Acta 1275 (1996) 161-203
26. Dalfo E., Portero-Otin M., Ayala V., Martinez A., Pamplona R., and Ferrer I. Evidence of oxidative stress in the neocortex in incidental Lewy body disease. J Neuropathol Exp Neurol 64 (2005) 816-830
27. Fukae J., Takanashi M., Kubo S., Nishioka K., Nakabeppu Y., Mori H., et al. Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders. Acta Neuropathol 109 (2005) 256-262
28. Logroscino G., Marder K., Graziano J., Freyer G., Salvkovich V., Loiacono N., et al. Paraquat and iron exposure as possible synergistic environmental risk factors in Parkinson's disease. Neurotoxicity Research 5 (2003) 307-313