Targeted knock down of CCL22 and CCL17 by siRNA during DC differentiation and maturation affects the recruitment of T subsets

Immunobiology

Volumn 215, Issue 2, 2010, Pages 153-162

  Kang, Shijun ^a,b   Xie, Jianmin ^a   Ma, Shudong ^a   Liao, Wangjun ^a   Zhang, Junyi ^a   Luo, Rongcheng ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

CCL17; CCL22; Migration; MoDC; siRNA; Tregs

Indexed keywords

CCL18 CHEMOKINE; CCL23 CHEMOKINE; CHEMOKINE; CUTANEOUS T CELL ATTRACTING CHEMOKINE; CXCL16 CHEMOKINE; CXCL3 CHEMOKINE; CXCL7 CHEMOKINE; EOTAXIN 2; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; INTERLEUKIN 8; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; SMALL INTERFERING RNA; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER IMMUNOLOGY; CD25+ T LYMPHOCYTE; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTIC INFILTRATION; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TUMOR XENOGRAFT;

ANIMALS; CANCER VACCINES; CD4-CD8 RATIO; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; CHEMOKINE CCL17; CHEMOKINE CCL22; DENDRITIC CELLS; FEMALE; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HUMANS; LYMPHOCYTE ACTIVATION; MICE; MICE, NUDE; NEOPLASMS; RNA, SMALL INTERFERING; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 71849099109     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2009.03.001     Document Type: Article

References (51)

1. Balkwill F. Cancer and the chemokine network. Nat. Rev. Cancer 4 (2004) 540-550
2. Bayry J., Tchilian E.Z., Davies M.N., Forbes E.K., Draper S.J., Kaveri S.V., Hill A.V., Kazatchkine M.D., Beverley P.C., Flower D.R., and Tough D.F. In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination. Proc. Natl. Acad. Sci. USA 105 (2008) 10221-10226
3. Beaty S.R., Rose Jr. C.E., and Sung S.S. Diverse and potent chemokine production by lung CD11bhigh dendritic cells in homeostasis and in allergic lung inflammation. J. Immunol. 178 (2007) 1882-1895
4. Bonnotte B., Crittenden M., Larmonier N., Gough M., and Vile R.G. MIP-3alpha transfection into a rodent tumor cell line increases intratumoral dendritic cell infiltration but enhances (facilitates) tumor growth and decreases immunogenicity. J. Immunol. 173 (2004) 4929-4935
5. Bottazzi B., Polentarutti N., Acero R., Balsari A., Boraschi D., Ghezzi P., Salmona M., and Mantovani A. Regulation of the macrophage content of neoplasms by chemoattractants. Science 220 (1983) 210-212
6. Brinckerhoff L.H., Thompson L.W., and Slingluff. Jr. C.L. Melanoma vaccines. Curr. Opin. Oncol. 12 (2000) 163-173
7. Curiel T.J., Coukos G., Zou L., Alvarez X., Cheng P., Mottram P., Evdemon-Hogan M., Conejo-Garcia J.R., Zhang L., Burow M., Zhu Y., Wei S., Kryczek I., Daniel B., Gordon A., Myers L., Lackner A., Disis M.L., Knutson K.L., Chen L., and Zou W. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 10 (2004) 942-949
8. Feijoo E., Alfaro C., Mazzolini G., Serra P., Penuelas I., Arina A., Huarte E., Tirapu I., Palencia B., Murillo O., Ruiz J., Sangro B., Richter J.A., Prieto J., and Melero I. Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8. Int. J. Cancer 116 (2005) 275-281
9. Fernandez N., Renedo M., Garcia-Rodriguez C., and Sanchez Crespo M. Activation of monocytic cells through Fc gamma receptors induces the expression of macrophage-inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES. J. Immunol. 169 (2002) 3321-3328
10. Furutani Y., Nomura H., Notake M., Oyamada Y., Fukui T., Yamada M., Larsen C.G., Oppenheim J.J., and Matsushima K. Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF). Biochem. Biophys. Res. Commun. 159 (1989) 249-255
11. Ghadially H., Ross X.L., Kerst C., Dong J., Reske-Kunz A.B., and Ross R. Differential regulation of CCL22 gene expression in murine dendritic cells and B cells. J. Immunol. 174 (2005) 5620-5629
12. Godiska R., Chantry D., Raport C.J., Sozzani S., Allavena P., Leviten D., Mantovani A., and Gray P.W. Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. J. Exp. Med. 185 (1997) 1595-1604
13. Grossman W.J., Verbsky J.W., Barchet W., Colonna M., Atkinson J.P., and Ley T.J. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 21 (2004) 589-601
14. Grove M., and Plumb M. C/EBP, NF-kappa B, and c-Ets family members and transcriptional regulation of the cell-specific and inducible macrophage inflammatory protein 1 alpha immediate-early gene. Mol. Cell Biol. 13 (1993) 5276-5289
15. Hannon G.J. RNA interference. Nature 418 (2002) 244-251
16. Hillenbrand E.E., Neville A.M., and Coventry B.J. Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumours. Br. J. Cancer 79 (1999) 940-944
17. Hiroi M., and Ohmori Y. The transcriptional coactivator CREB-binding protein cooperates with STAT1 and NF-kappa B for synergistic transcriptional activation of the CXC ligand 9/monokine induced by interferon-gamma gene. J. Biol. Chem. 278 (2003) 651-660
18. Imai T., Nagira M., Takagi S., Kakizaki M., Nishimura M., Wang J., Gray P.W., Matsushima K., and Yoshie O. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int. Immunol. 11 (1999) 81-88
19. Katou F., Ohtani H., Nakayama T., Ono K., Matsushima K., Saaristo A., Nagura H., Yoshie O., and Motegi K. Macrophage-derived chemokine (MDC/CCL22) and CCR4 are involved in the formation of T lymphocyte-dendritic cell clusters in human inflamed skin and secondary lymphoid tissue. Am. J. Pathol. 158 (2001) 1263-1270
20. Langenkamp A., Messi M., Lanzavecchia A., and Sallusto F. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat. Immunol. 1 (2000) 311-316
21. Larmonier N., Marron M., Zeng Y., Cantrell J., Romanoski A., Sepassi M., Thompson S., Chen X., Andreansky S., and Katsanis E. Tumor-derived CD4(+) CD25(+) regulatory T cell suppression of dendritic cell function involves TGF-beta and IL-10. Cancer Immunol. Immunother. 56 (2007) 48-59
22. Lutz M.B., and Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?. Trends Immunol. 23 (2002) 445-449
23. Mahnke K., Schmitt E., Bonifaz L., Enk A.H., and Jonuleit H. Immature, but not inactive: the tolerogenic function of immature dendritic cells. Immunol. Cell Biol. 80 (2002) 477-483
24. Milliken D., Scotton C., Raju S., Balkwill F., and Wilson J. Analysis of chemokines and chemokine receptor expression in ovarian cancer ascites. Clin. Cancer Res. 8 (2002) 1108-1114
25. Mizukami Y., Kono K., Kawaguchi Y., Akaike H., Kamimura K., Sugai H., and Fujii H. CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer. Int. J. Cancer 122 (2008) 2286-2293
26. Muthuswamy R., Urban J., Lee J.J., Reinhart T.A., Bartlett D., and Kalinski P. Ability of mature dendritic cells to interact with regulatory T cells is imprinted during maturation. Cancer Res. 68 (2008) 5972-5978
27. Negus R.P., Stamp G.W., Hadley J., and Balkwill F.R. Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines. Am. J. Pathol. 150 (1997) 1723-1734
28. Negus R.P., Stamp G.W., Relf M.G., Burke F., Malik S.T., Bernasconi S., Allavena P., Sozzani S., Mantovani A., and Balkwill F.R. The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer. J. Clin. Invest. 95 (1995) 2391-2396
29. Niess J.H., and Reinecker H.C. Dendritic cells: the commanders-in-chief of mucosal immune defenses. Curr. Opin. Gastroenterol. 22 (2006) 354-360
30. O'Garra A., McEvoy L.M., and Zlotnik A. T-cell subsets: chemokine receptors guide the way. Curr. Biol. 8 (1998) R646-R649
31. Ohmori Y., Schreiber R.D., and Hamilton T.A. Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB. J. Biol. Chem. 272 (1997) 14899-14907
32. Payne A.S., and Cornelius L.A. The role of chemokines in melanoma tumor growth and metastasis. J. Invest. Dermatol. 118 (2002) 915-922
33. Piqueras B., Connolly J., Freitas H., Palucka A.K., and Banchereau J. Upon viral exposure, myeloid and plasmacytoid dendritic cells produce 3 waves of distinct chemokines to recruit immune effectors. Blood 107 (2006) 2613-2618
34. Qian, C., An, H., Yu, Y., Liu, S., Cao, X., 2006. TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation. Blood.
35. Randolph G.J., Angeli V., and Swartz M.A. Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat. Rev. Immunol. 5 (2005) 617-628
36. Reay P.A. Dendritic cells: immunological features and utilisation for tumour immunotherapy. Expert Opin. Ther. Targets 5 (2001) 491-506
37. Sallusto F., Palermo B., Lenig D., Miettinen M., Matikainen S., Julkunen I., Forster R., Burgstahler R., Lipp M., and Lanzavecchia A. Distinct patterns and kinetics of chemokine production regulate dendritic cell function. Eur. J. Immunol. 29 (1999) 1617-1625
38. Schutyser E., Richmond A., and Van Damme J. Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes. J. Leukoc. Biol. 78 (2005) 14-26
39. Sebastiani S., Allavena P., Albanesi C., Nasorri F., Bianchi G., Traidl C., Sozzani S., Girolomoni G., and Cavani A. Chemokine receptor expression and function in CD4+ T lymphocytes with regulatory activity. J. Immunol. 166 (2001) 996-1002
40. Shevach E.M. Regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 18 (2000) 423-449
41. Sozzani S. Dendritic cell trafficking: more than just chemokines. Cytokine Growth Factor Rev. 16 (2005) 581-592
42. Steinman R.M., Hawiger D., and Nussenzweig M.C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21 (2003) 685-711
43. Tacke F., and Randolph G.J. Migratory fate and differentiation of blood monocyte subsets. Immunobiology 211 (2006) 609-618
44. Tanaka K., Ito A., Kobayashi T., Kawamura T., Shimada S., Matsumoto K., Saida T., and Honda H. Intratumoral injection of immature dendritic cells enhances antitumor effect of hyperthermia using magnetic nanoparticles. Int. J. Cancer 116 (2005) 624-633
45. Tang H.L., and Cyster J.G. Chemokine up-regulation and activated T cell attraction by maturing dendritic cells. Science 284 (1999) 819-822
46. Thornton A.M., and Shevach E.M. Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J. Immunol. 164 (2000) 183-190
47. Vissers J.L., Hartgers F.C., Lindhout E., Teunissen M.B., Figdor C.G., and Adema G.J. Quantitative analysis of chemokine expression by dendritic cell subsets in vitro and in vivo. J. Leukoc. Biol. 69 (2001) 785-793
48. Vulcano M., Albanesi C., Stoppacciaro A., Bagnati R., D'Amico G., Struyf S., Transidico P., Bonecchi R., Del Prete A., Allavena P., Ruco L.P., Chiabrando C., Girolomoni G., Mantovani A., and Sozzani S. Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo. Eur. J. Immunol. 31 (2001) 812-822
49. Wolpe S.D., Davatelis G., Sherry B., Beutler B., Hesse D.G., Nguyen H.T., Moldawer L.L., Nathan C.F., Lowry S.F., and Cerami A. Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. J. Exp. Med. 167 (1988) 570-581
50. Xu Z., Huang C.X., Li Y., Wang P.Z., Ren G.L., Chen C.S., Shang F.J., Zhang Y., Liu Q.Q., Jia Z.S., Nie Q.H., Sun Y.T., and Bai X.F. Toll-like receptor 4 siRNA attenuates LPS-induced secretion of inflammatory cytokines and chemokines by macrophages. J. Infect. (2007)
51. Zlotnik A., and Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity 12 (2000) 121-127