Exacerbation of spinal cord injury due to static compression occurring early after onset: Laboratory investigation

Journal of Neurosurgery: Spine

Volumn 11, Issue 5, 2009, Pages 570-574

  Swartz, Karin R ^a   Scheff, Nicole N ^a   Roberts, Kelly N ^a   Fee, Dominic B ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Compression; Dwell; Injury; Pathophysiology; Spinal cord

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DISEASE EXACERBATION; FEMALE; GRAY MATTER; LAMINECTOMY; NONHUMAN; OPERATION DURATION; OUTCOME ASSESSMENT; RAT; RATING SCALE; SCORING SYSTEM; SPINAL CORD COMPRESSION; SPINAL CORD INJURY; THORACIC SPINAL CORD; WHITE MATTER;

ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EDEMA; FEMALE; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SPINAL CORD COMPRESSION; SPINAL CORD INJURIES;

EID: 71849093994     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/2009.5.SPINE08588     Document Type: Article

References (25)

1. Anonymous: Guidelines for management of acute cervical spinal injuries. Introduction. Neurosurgery 50 (3 Suppl):S1, 2002
2. Basso DM, Beattie MS, Bresnahan JC: Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 139:244-256, 1996
3. Basso DM, Beattie MS, Bresnahan JC: A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21, 1995
4. Carlson GD, Gorden CD, Oliff HS, Pillai JJ, LaManna JC: Sustained spinal cord compression: part I: time-dependent effect on long-term pathophysiology. J Bone Joint Surg Am 85: 86-94, 2003
5. Carlson GD, Minato Y, Okada A, Gorden CD, Warden KE, Barbeau JM, et al: Early time-dependent decompression for spinal cord injury: vascular mechanisms of recovery. J Neurotrauma 14:951-962, 1997 (Pubitemid 28087520)
6. Delamarter RB, Sherman J, Carr JB: Pathophysiology of spinal cord injury. Recovery after immediate and delayed decompression. J Bone Joint Surg Am 77:1042-1049, 1995
7. Dimar JR II, Glassman SD, Raque GH, Zhang YP, Shields CB: The influence of spinal canal narrowing and timing of decompression on neurologic recovery after spinal cord contusion in a rat model. Spine 24:1623-1633, 1999
8. Dolan EJ, Tator CH, Endrenyi L: The value of decompression for acute experimental spinal cord compression injury. J Neurosurg 53:749-755, 1980 (Pubitemid 11194433)
9. Fee DB, Swartz KR, Joy KM, Roberts KN, Scheff NN, Scheff SW: Effects of progesterone on experimental spinal cord injury. Brain Res 1137:146-152, 2007 (Pubitemid 46240051)
10. Fehlings MG, Perrin RG: The role and timing of early decompression for cervical spinal cord injury: update with a review of recent clinical evidence. Injury 36 (2 Suppl):B13-B26, 2005
11. Fehlings MG, Sekhon LH, Tator C: The role and timing of decompression in acute spinal cord injury: what do we know? What should we do? Spine 26:S101-S110, 2001
12. Kasahara K, Nakagawa T, Kubota T: Neuronal loss and expression of neurotrophic factors in a model of rat chronic compressive spinal cord injury. Spine 31:2059-2066, 2006 (Pubitemid 44246378)
13. Kim P, Haisa T, Kawamoto T, Kirino T, Wakai S: Delayed myelopathy induced by chronic compression in the rat spinal cord. Ann Neurol 55:503-511, 2004 (Pubitemid 38391967)
14. Rabchevsky AG, Fugaccia I, Sullivan PG, Blades DA, Scheff SW: Efficacy of methylprednisolone therapy for the injured rat spinal cord. J Neurosci Res 68:7-18, 2002 (Pubitemid 34274992)
15. Rabchevsky AG, Fugaccia I, Sullivan PG, Scheff SW: Cyclosporin A treatment following spinal cord injury to the rat: behavioral effects and stereological assessment of tissue sparing. J Neurotrauma 18:513-522, 2001 (Pubitemid 32472841)
16. Rabchevsky AG, Fugaccia I, Turner AF, Blades DA, Mattson MP, Scheff SW: Basic fibroblast growth factor (bFGF) enhances functional recovery following severe spinal cord injury to the rat. Exp Neurol 164:280-291, 2000 (Pubitemid 32008973)
17. Rabchevsky AG, Sullivan PG, Fugaccia I, Scheff SW: Creatine diet supplement for spinal cord injury: influences on functional recovery and tissue sparing in rats. J Neurotrauma 20: 659-669, 2003
18. Rivlin AS, Tator CH: Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat. Surg Neurol 10:38-43, 1978
19. Scheff SW, Rabchevsky AG, Fugaccia I, Main JA, Lumpp JE Jr: Experimental modeling of spinal cord injury: characterization of a force-defined injury device. J Neurotrauma 20: 179-193, 2003 (Pubitemid 36292827)
20. Scheff SW, Saucier DA, Cain ME: A statistical method for analyzing rating scale data: the BBB locomotor score. J Neurotrauma 19:1251-1260, 2002
21. Sekhon LH, Fehlings MG: Epidemiology, demographics, and pathophysiology of acute spinal cord injury. Spine 26 (24 Suppl):S2-S12, 2001 (Pubitemid 34019773)
22. Sheng H, Wang H, Homi HM, Spasojevic I, Batinic-Haberle I, Pearlstein RD, et al: A no-laminectomy spinal cord compression injury model in mice. J Neurotrauma 21:595-603, 2004 (Pubitemid 38656756)
23. Shields CB, Zhang YP, Shields LB, Han Y, Burke DA, Mayer NW: The therapeutic window for spinal cord decompression in a rat spinal cord injury model. J Neurosurg Spine 3:302-307, 2005
24. Swartz KR, Fee DB, Joy KM, Roberts KN, Sun S, Scheff NN, et al: Gender differences in spinal cord injury are not estrogen- dependent. J Neurotrauma 24:473-480, 2007 (Pubitemid 46598281)
25. Tarlov IM, Klinger H: Spinal cord compression studies. II. Time limits for recovery after acute compression in dogs. AMA Arch Neurol Psychiatry 71:271-290, 1954