Protein kinase C-mediated translocation of secretory vesicles to plasma membrane and enhancement of neurotransmitter release from PC12 cells

European Journal of Neuroscience

Volumn 15, Issue 8, 2002, Pages 1390-1394

  Shoji Kasai, Yoko ^a   Itakura, Makoto ^a   Kataoka, Masakazu ^b   Yamamori, Saori ^a   Takahashi, Masami ^a  

^a MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

^b SHINSHU UNIVERSITY   (Japan)

Author keywords

GFP; Phorbol ester; Phosphorylation; VAChT; VMAT

Indexed keywords

ACETYLCHOLINE; BISINDOLYLMALEIMIDE; DOPAMINE; GREEN FLUORESCENT PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; VESICULAR ACETYLCHOLINE TRANSPORTER;

ANIMAL CELL; ARTICLE; CELL LABELING; CELL MEMBRANE DEPOLARIZATION; CELL STRAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DOPAMINE RELEASE; ENZYME MECHANISM; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SECRETORY VESICLE;

ACETYLCHOLINE; ANIMALS; CARCINOGENS; CARRIER PROTEINS; CELL MEMBRANE; CENTRAL NERVOUS SYSTEM; DOPAMINE; ENZYME INHIBITORS; GREEN FLUORESCENT PROTEINS; INDICATORS AND REAGENTS; LUMINESCENT PROTEINS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; PC12 CELLS; PRESYNAPTIC TERMINALS; PROTEIN KINASE C; PROTEIN TRANSPORT; RATS; SECRETORY VESICLES; SYNAPTIC VESICLES; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; TETRADECANOYLPHORBOL ACETATE; VESICULAR ACETYLCHOLINE TRANSPORT PROTEINS; VESICULAR BIOGENIC AMINE TRANSPORT PROTEINS; VESICULAR MONOAMINE TRANSPORT PROTEINS; VESICULAR TRANSPORT PROTEINS;

EID: 0036459950     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2002.01972.x     Document Type: Article

References (24)

1. Ashery, U., Varoqueaux, F., Voets, T., Betz, A., Thakur, P., Neher, E., Brose, N. & Retting, J. (2000) Munc13-1 act as a priming factor for large dense-core vesicles in bovine chromaffin cells. EMBO J., 19, 3586-3596.
2. Augustin, I., Korte, S., Rickmann, M., Kretzschmar, H.A., Sudhof, T.C., Herms, J.W. & Brose, N. (2001) The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice. J. Neurosci., 21, 10-7.
3. Augustin, I., Rosenmund, C., Sudhof, T.C. & Brose, N. (1999) Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles. Nature, 400, 457-461.
4. Betz, A., Ashery, U., Rickmann, M., Augustin, I., Neher, E., Sudhof, T.C., Retting, J. & Brose, N. (1998) Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release. Neuron, 21, 123-136.
5. Cubitt, A.B., Heim, R., Adams, S.R., Boyd, A.E., Gross, L.A. & Tsien, R.Y. (1995) Understanding, improving and using green fluorescent proteins. Trends Biochem. Sci., 20, 448-455.
6. De Camilli, P. (1991) Co-secretion of multiple signal molecules from endocrine cells via distinct exocytotic pathways. Trends. Pharmacol. Sci., 12, 446-448.
7. Duncan, R.R., Betz, A., Shipston, M.J., Brose, N. & Chow, R.H. (1999) Transient phorbol ester-induced DOC2-Munc13 interactions in vivo. J. Biol. Chem., 274, 27347-27350.
8. Gekeler, V., Boer, R., Uberall, F., Ise, W., Schubert, C., Utz, I., Hofmann, J., Sandeers, K.H., Schachtele, C., Klemm, K. & Grunicke, H. (1996) Effect of the selective bisindolylmaleimide protein kinase C inhibitor CF 109203X on P-glycoprotein-mediated multidrug resistance. Br. J. Cancer, 74, 897-905.
9. Gillis, K.D., Mossner, R. & Neher, E. (1996) Protein kinase C enhances exocytosis from chromaffin cells by increasing the size of the readily releasable pool of secretory granules. Neuron, 16, 1209-1220.
10. Greene, L.A. & Tischler, A.A. (1982) PC12 pheochomocytoma cultures in neurobiological research. Adv. Cell Neurobiol., 3, 373-414.
11. Greengard, P., Valtorta, F., Czernik, A.J. & Benfenati, F. (1993) Synaptic vesicle phosphoproteins and regulation of synptic function. Science, 259, 780-785.
12. Itakura, M., Misawa, H., Sekiguchi, M., Takahashi, S. & Takahashi, M. (1999) Transfection analysis of functional roles of complexin I and II in the exocytosis of two deferent types of secretory vesicles. Biochem. Biophys. Res. Commun., 265, 691-696.
13. Iwasaki, S., Kataoka, M., Sekiguchi, M., Shimazaki, Y., Sato, K. & Takahashi, M. (2000) Two distinct mechanisms underlie the stimulation of neurotransmitter release by phorbol esters in clonal rat pheochromocytoma PC12 cells. J. Biochem., 128, 407-414.
14. Jessell, T.M. & Kandel, E.R. (1993) Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication. Cell Suppl., 1-30.
15. Kataoka, M., Kuwahara, R., Iwasaki, S., Shoji-Kasai, Y. & Takahashi, M. (2000) Nerve growth factor-induced phosphorylation of SNAP-25 in PC12 cells: A possible involvement in the regulation of SNAP-25 localization. J. Neurochem., 74, 2058-2066
16. Lin, R.C. & Scheller, R.H. (2000) Mechanisms of synaptic vesicle exocytosis. Annu. Rev. Cell Dev. Biol., 16, 19-49.
17. Minami, N., Berglund, K., Sakaba, T., Kohmoto, H. & Tachibana, M. (1998) Potentiation of transmitter release by protein kinase C in goldfish retinalbioilar cells. J. Physiol. (Lond.), 512, 219-225.
18. Shimazaki, Y., Nishiki, T., Omori, A., Sekiguchi. M., Kamata, Y., Kozaki, S. & Takahashi, M. (1996) Phosphorylation of 25-kDa synaptosome-associated protein. J. Biol. Chem, 271, 14548-14553.
19. Shoji-Kasai, Y., Morishima, M., Kuwahara, R., Kondo, S., Itakura, M. & Takahashi, M. (2001) Establishment of variant PC12 subclones deficient in stimulation-secretion coupling. Biochim. Biophys. Acta, 1499, 180-190.
20. Shoji-Kasai, Y., Yoshida, A., Sato, K., Hoshino, T., Ogura, A., Kondo, S., Fujimoto, Y., Kuwahara, R. & Takahashi, M. (1992) Neurotransmitter release from synaptotagmin-defecient clonal variants of PC12 cells. Science, 256, 1820-1823.
21. Sudhof, T.C. (1995) The synaptic vesicle cycle: A cascade of protein-protein interactions. Nature, 375, 645-653.
22. Tsuboi, T., Kikuta, T., Warashina, A. & Terakawa, S. (2001) Protein kinase C-dependent supply of secretory granules to the plasma membrane. Biochem. Biophys. Res. Commun., 282, 621-628.
23. Weihe, E. & Eiden, L.E. (2000) Chemical neuroanatomy of the vesicular amine transporters. FASEB J., 14, 2435-2449.
24. Yawo, H. (1999) Protein kinase C potentiates transmitter release from the chick ciliary presynaptic fusion probability. J. Physiol. (Lond.), 515, 169-180.