Genomic structure of mouse IA-2: Comparison with its human homologue

Diabetologia

Volumn 43, Issue 11, 2000, Pages 1429-1434

  Saeki, K ^a   Xie, J ^a   Notkins, A L ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Autoantibodies; Genomic structure; IA 2; Insulin dependent diabetes mellitus; Intron exon junctions; Protein tyrosine phosphatase

Indexed keywords

AUTOANTIGEN; MEMBRANE PROTEIN; PROTEIN TYROSINE PHOSPHATASE;

ARTICLE; COMPARATIVE STUDY; DNA DETERMINATION; EXON; GENE STRUCTURE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INTRON; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION MAPPING;

AMINO ACID SEQUENCE; ANIMALS; AUTOANTIGENS; BASE SEQUENCE; CONSERVED SEQUENCE; EXONS; HUMANS; INTRONS; ISLETS OF LANGERHANS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); PROTEIN-TYROSINE-PHOSPHATASE; REGULATORY SEQUENCES, NUCLEIC ACID; RESTRICTION MAPPING; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY;

EID: 0033736094     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051550     Document Type: Article

References (21)

1. Molecular cloning and identification of a recptor-type protein tyrosine phosphatase, IA-2, from human insulinoma
2. IA-2 and IA-2β: The immune response in IDDM
3. Identification of a second transmembrane protein tyrosine phosphatase, IA-2β, as an autoantigen in insulin-dependent diabetes mellitus: Precursor of the 37-kDa tryptic fragment
4. Comparison of IA-2 with IA-2β and with six other members of the protein tyrosine phosphatase family: Recognition of antigenic determinants by IDDM sera
5. Isolation, sequence and expression of a novel mouse brain cDNA, mIA-2, and its relatedness to members of the protein tyrosine phosphatase family
6. IA-2-autoantibody complement GAD-65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. The Belgian Diabetes Registry
7. Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes
8. Prediction of insulin-dependent-diabetes mellitus in siblings of children with diabetes: A population-based study. The Childhood Diabetes in Finland Study Group
9. IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus
10. Autoantigens IA-2 and GAD in Type I (Insulin-Dependent) Diabetes
11. Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2β predict immune-mediated (type 1) diabetes in relatives
12. Prediction of type 1 diabetes in first-degree relatives using a combination of insulin, GAD and ICA512bdc/IA-2 autoantibodies
13. Genomic structure and promoter sequence of the insulin-dependent diabetes mellitus autoantigen, IA-2 (PTPRN)
14. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction
15. Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer
16. Complete exon-intron organization of the human leukocyte common antigen (CD45) gene
17. Sequence conservation in potential regulatory regions of the mouse and human leukocyte common antigen gene
18. Leukocytes common antigen-related phosphatase (LRP) gene structure: Conservation of the genomic organization of transm embrane protein tyrosine phosphatases
19. A catalogue splice junction sequence
20. Genomic organization of human and mouse genes for vascular endothelial growth factor C
21. Characterization and comparison of the human and mouse GLC1A glaucoma genes