Dual acting norepinephrine reuptake inhibitors and 5-HT2A receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 22, 2009, Pages 7802-7815

  Heffernan, Gavin D ^a   Coghlan, Richard D ^a   Manas, Eric S ^a   McDevitt, Robert E ^a   Li, Yanfang ^a   Mahaney, Paige E ^a   Robichaud, Albert J ^a   Huselton, Christine ^a   Alfinito, Peter ^a   Bray, Jenifer A ^a   Cosmi, Scott A ^a   Johnston, Grace H ^a   Kenney, Thomas ^a   Koury, Elizabeth ^a   Winneker, Richard C ^a   Deecher, Darlene C ^a   Trybulski, Eugene J ^a  

^a PFIZER INC   (United States)

Author keywords

4 Aminoethyl 3 (phenylsulfonyl) 1H indoles; 5 HT2A receptor antagonists; Monoamine reuptake inhibitors; Norepinephrine reuptake inhibitors; NRI

Indexed keywords

3 (PHENYLSULFONYL) 4 (2 PIPERIDIN 1 YLETHYL) 1H INDOLE; 4 AMINOETHYL 3 (PHENYLSULFONYL) 1H INDOLE DERIVATIVE; INDOLE DERIVATIVE; NORADRENALIN UPTAKE INHIBITOR; SEROTONIN 2A ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

BIOLOGICAL TRANSPORT; CELL LINE; HUMANS; INDOLES; NEUROTRANSMITTER UPTAKE INHIBITORS; NOREPINEPHRINE; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 71749116274     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.09.023     Document Type: Article

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