Novel 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3- d]oxepin derivatives displaying combined norepinephrine reuptake inhibition and 5-HT2A/2C receptor antagonism

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 11, 2005, Pages 2898-2901

  Bartolomé, José M ^a   Alcudia, Ana ^a   Andrés, José I ^a   Cid, José M ^a   García, Mercedes ^a   Megens, Anton ^b   Toledo, Miguel A ^a   Trabanco, Andrés A ^a  

^a JOHNSON AND JOHNSON   (United States)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Antidepressant; Anxiolytic; Norepinephrine; Serotonin

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; NORADRENALIN TRANSPORTER; NORADRENALIN UPTAKE INHIBITOR; OXEPINE DERIVATIVE; SEROTONIN 2A ANTAGONIST; SEROTONIN 2C ANTAGONIST;

ANIMAL CELL; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; CONVULSION; CYANOSIS; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HYPOTHERMIA; MOUSE; NONHUMAN; PREDICTION; RAT; TRANQUILIZING ACTIVITY;

BENZOFURANS; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; OXEPINS; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN ANTAGONISTS; SYMPORTERS;

EID: 19544377518     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.03.076     Document Type: Article

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