Recombinant human epidermal growth factor accelerates the proliferation of irradiated human fibroblasts and keratinocytes in vitro and in vivo

Journal of Radiation Research

Volumn 50, Issue 6, 2009, Pages 545-552

  Ryu, Seung Hee ^a   Moon, Soo Young ^a   Yang, Youn Joo ^a   Moon, Sun Rock ^b   Hong, Joon Pio ^a   Choi, Jene ^a   Lee, Sang wook ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Wonkwang University   (South Korea)

Author keywords

BALB c mice; Fibroblast; Irradiation; Keratinocyte; Recombinant human epidermal growth factor (rhEGF)

Indexed keywords

CELL CULTURE; FIBROBLASTS; MAMMALS; RADIATION EFFECTS;

BALB/C MICE; CELL-BE; CELL/B.E; CELL/BE; EPIDERMAL GROWTH FACTORS; FIBROBLAST; HUMAN EPIDERMAL GROWTH FACTOR; KERATINOCYTES; RADIATION-INDUCED; RECOMBINANT HUMAN EPIDERMAL GROWTH FACTOR;

IRRADIATION;

MUS;

EID: 71749102198     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.09066     Document Type: Article

References (43)

1. Sonis, S. T. (2004) Pathobiology of mucositis. Semin. Oncol. Nurs. 20: 11-15.
2. Sonis, S. T. (2004) Oral mucositis in cancer therapy. J. Support. Oncol. 2: 3-8.
3. Sonis, S. T. (2007) Pathobiology of oral mucositis: novel insights and opportunities. J. Support. Oncol. 5: 3-11.
4. Sonis, S. T., Elting, L. S., Keefe, D., Peterson, D. E., Schubert, M., Hauer-Jensen, M., Bekele, B. N., Raber-Durlacher, J., Donnelly, J. P. and Rubenstein, E. B. (2004) Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100: 1995-2025.
5. Sonis, S. T. (1998) Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity. Oral. Oncol. 34: 39-43.
6. Hall, E. J. and Giaccia, A. J. (2006) Clinical reponse of normal tissues. In: Radiobiology for the radiologist, Eds. Hall, E. J. and Giaccia, A. J., pp. 327-348, Lippincott Williams & Wilkins, Philadelphia.
7. Rudolph, R., Vande Berg, J., Schneider, J. A., Fisher, J. C. and Poolman, W. L. (1988) Slowed growth of cultured fibroblasts from human radiation wounds. Plast. Reconstr. Surg. 82: 669-677.
8. Wang, Q., Dickson, G. R., Abram, W. P. and Carr, K. E. (1994) Electron irradiation slows down wound repair in rat skin: a morphological investigation. Br. J. Dermatol. 130: 551-560.
9. Withers, H. R. (1992) Biologic basis of radiation therapy. In: Principles and practice of radiation oncology, Eds. Perez, C. and Brady, L., pp. 64-96, Lippincott Williams & Wilkins, Philadelphia.
10. Dorr, W., Hamilton, C. S., Boyd, T., Reed, B. and Denham, J. W. (2002) Radiation-induced changes in cellularity and proliferation in human oral mucosa. Int. J. Radiat. Oncol. Biol. Phys. 52: 911-917.
11. Dorr, W., Jacubek, A., Kummermehr, J., Herrmann, T., Dolling- Jochem, I. and Eckelt, U. (1995) Effects of stimulated repopulation on oral mucositis during conventional radiotherapy. Radiother. Oncol. 37: 100-107.
12. Dorr, W., Emmendorfer, H., Haide, E. and Kummermehr, J. (1994) Proliferation equivalent of 'accelerated repopulation' in mouse oral mucosa. Int. J. Radiat. Biol. 66: 157-167.
13. Dorr, W. and Kummermehr, J. (1991) Proliferation kinetics of mouse tongue epithelium under normal conditions and following single dose irradiation. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. 60: 287-294.
14. Garden, A. S. (2003) Mucositis: current management and investigations. Semin. Radiat. Oncol. 13: 267-273.
15. Lee, S. W., Jung, K. I., Kim, Y. W., Jung, H. D., Kim, H. S. and Hong, J. P. (2007) Effect of epidermal growth factor against radiotherapy-induced oral mucositis in rats. Int. J. Radiat. Oncol. Biol. Phys. 67: 1172-1178.
16. Carpenter, G. and Cohen, S. (1979) Epidermal growth factor. Annu. Rev. Biochem. 48: 193-216.
17. Cohen, S. (1962) Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. J. Biol. Chem. 237: 1555-1562.
18. Savage, C. R. Jr., Inagami, T. and Cohen, S. (1972) The primary structure of epidermal growth factor. J. Biol. Chem. 247: 7612-7621.
19. Taylor, J. M., Mitchell, W. M. and Cohen, S. (1972) Epidermal growth factor. Physical and chemical properties. J. Biol. Chem. 247: 5928-5934.
20. Carpenter, G. and Cohen, S. (1976) Human epidermal growth factor and the proliferation of human fibroblasts. J. Cell. Physiol. 88: 227-237.
21. Weaver, L. T., Gonnella, P. A., Israel, E. J. and Walker, W. A. (1990) Uptake and transport of epidermal growth factor by the small intestinal epithelium of the fetal rat. Gastroenterology 98: 828-837.
22. Cohen, S. (1983) The epidermal growth factor (EGF). Cancer 51: 1787-1791.
23. Steidler, N. E. and Reade, P. C. (1980) Histomorphological effects of epidermal growth factor on skin and oral mucosa in neonatal mice. Arch. Oral. Biol. 25: 37-43.
24. Waterfield, M. D. (1989) Epidermal growth factor and related molecules. Lancet 1: 1243-1246.
25. Ino, M., Ushiro, K., Ino, C., Yamashita, T. and Kumazawa, T. (1993) Kinetics of epidermal growth factor in saliva. Acta. Otolaryngol. Suppl. 500: 126-130.
26. Thesleff, I., Viinikka, L., Saxen, L., Lehtonen, E. and Perheentupa, J. (1988) The parotid gland is the main source of human salivary epidermal growth factor. Life Sci. 43: 13-18.
27. Epstein, J. B., Emerton, S., Guglietta, A. and Le, N. (1997) Assessment of epidermal growth factor in oral secretions of patients receiving radiation therapy for cancer. Oral Oncol. 33: 359-363.
28. Carpenter, G. (1980) Epidermal growth factor is a major growth-promoting agent in human milk. Science 210: 198-199.
29. Heitz, P. U., Kasper, M., van Noorden, S., Polak, J. M., Gregory, H. and Pearse, A. G. (1978) Immunohistochemical localisation of urogastrone to human duodenal and submandibular glands. Gut. 19: 408-413.
30. Olsen, P. S., Poulsen, S. S., Therkelsen, K. and Nexo, E. (1986) Effect of sialoadenectomy and synthetic human urogastrone on healing of chronic gastric ulcers in rats. Gut. 27: 1443-1449.
31. Kamata, N., Chida, K., Rikimaru, K., Horikoshi, M., Enomoto, S. and Kuroki, T. (1986) Growth-inhibitory effects of epidermal growth factor and overexpression of its receptors on human squamous cell carcinomas in culture. Cancer Res. 46: 1648-1653.
32. Cowley, G., Smith, J. A., Gusterson, B., Hendler, F. and Ozanne, B. (1984) The amount of EGF receptor is elevated on squamous cell carcinoma. In: Cancer Cells, Eds. Levine, A. J., Vande Wounde, G. F., Topp, W. C. and Waston, J. D., pp. 5-10, Cold Spring Harbor, NY.
33. Buss, J. E., Kudlow, J. E., Lazar, C. S. and Gill, G. N. (1982) Altered epidermal growth factor (EGF)-stimulated protein kinase activity in variant A431 cells with altered growth responses to EGF. PNAS 79: 2574-2578.
34. Ning, S., Shui, C., Khan, W. B., Benson, W., Lacey, D. L. and Knox, S. J. (1998) Effects of keratinocyte growth factor on the proliferation and radiation survival of human squamous cell carcinoma cell lines in vitro and in vivo. Int. J. Radiat. Oncol. Biol. Phys. 40: 177-187.
35. Syljuasen, R. G., Jensen, S., Bartek, J. and Lukas, J. (2006) Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases. Cancer Res. 66: 10253-10257.
36. Elkind, M. M., Sutton-Gilbert, H., Moses, W. B., Alescio, T. and Swain, R. W. (1965) Radiation Response of Mammalian Cells Grown in Culture. V. Temperature Dependence of the Repair of X-Ray Damage in Surviving Cells (Aerobic and Hypoxic). Radiat. Res. 25: 359-376.
37. Kwok, T. T. and Sutherland, R. M. (1989) Enhancement of sensitivity of human squamous carcinoma cells to radiation by epidermal growth factor. J. Natl. Cancer Inst. 81: 1020-1024.
38. Takuwa, N., Fukui, Y. and Takuwa, Y. (1999) Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts. Mol. Cell. Biol. 19: 1346-1358.
39. Rodriguez, P., Barquinero, J. F., Duran, A., Caballin, M. R., Ribas, M. and Barrios, L. (2009) Cells bearing chromosome aberrations lacking one telomere are selectively blocked at the G2/M checkpoint. Mutat. Res. (in press)
40. Iliakis, G., Wang, Y., Guan, J. and Wang, H. (2003) DNA damage checkpoint control in cells exposed to ionizing radiation. Oncogene 22: 5834-5847.
41. Lee, K. K., Jo, H. J., Hong, J. P., Lee, S. W., Sohn, J. S., Moon, S. Y., Yang, S. H., Shim, H., Lee, S. H., Ryu, S. H. and Moon, S. R. (2008) Recombinant human epidermal growth factor accelerates recovery of mouse small intestinal mucosa after radiation damage. Int. J. Radiat. Oncol. Biol. Phys. 71: 1230-1235.
42. Lee, S. W., Moon, S. Y., Kim, Y. H. and Hong, J. P. (2007) The use of recombinant human epidermal growth factor to promote healing for chronic radiation ulcer. Int. Wound J. 4: 216-220.
43. Wu, H. G., Song, S. Y., Kim, Y. S., Oh, Y. T., Lee, C. G., Keum, K. C., Ahn, Y. C. and Lee, S. W. (2009) Therapeutic effect of recombinant human epidermal growth factor (rhEGF) on mucositis in patients undergoing radiotherapy, with or without chemotherapy, for head and neck cancer: a double-blind placebo-controlled prospective phase 2 multi-institutional clinical trial. Cancer 115: 3699-3708.