Quantitative evaluation of T-cell response after specific antigen stimulation in active and latent tuberculosis infection in adults and children

Diagnostic Microbiology and Infectious Disease

Volumn 65, Issue 3, 2009, Pages 236-246

  Latorre, Irene ^a,b,c   De Souza Galvão, Malú ^b,d   Ruiz Manzano, Juan ^a,b,c   Lacoma, Alicia ^a,b,c   Prat, Cristina ^a,b,c   Fuenzalida, Loreto ^a,b   Altet, Neus ^d   Ausina, Vicente ^a,b,c   Domínguez, Jose ^a,b,c  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d Unidad de Pre vención y Control de la Tuberculosis   (Spain)

Author keywords

Active TB; Children; IFN tests; LTBI; Mycobacterial burden

Indexed keywords

BCG VACCINE; IMMUNOSUPPRESSIVE AGENT; MYCOBACTERIUM ANTIGEN; PROTEIN RD1; T LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG;

ADULT; ANTIGEN SPECIFICITY; ARTICLE; CHILD; CONTROLLED STUDY; EXTRAPULMONARY TUBERCULOSIS; FEMALE; HUMAN; IMMUNOSTIMULATION; LUNG TUBERCULOSIS; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; PROBABILITY; QUANTITATIVE ANALYSIS; T LYMPHOCYTE; TUBERCULOSIS;

ADOLESCENT; ADULT; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CELL PROLIFERATION; CHILD; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES, T-LYMPHOCYTE; FEMALE; HUMANS; LATENT TUBERCULOSIS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; REAGENT KITS, DIAGNOSTIC; ROC CURVE; STATISTICS, NONPARAMETRIC; T-LYMPHOCYTES; TUBERCULOSIS;

EID: 71749093511     PISSN: 07328893     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2009.07.015     Document Type: Article

References (52)

1. Andersen P., Munk M.E., Pollock J.M., and Doherty T.M. Specific immune-based diagnosis of tuberculosis. Lancet 356 (2000) 1099-1104
2. Arend S.M., Thijsen S.F., Leyten E.M., Bouwman J.J., Franken W.P., Koster B.F., Cobelens F.G., van Houte A.J., and Bossink A.W. Comparison of two interferon-gamma assays and tuberculin skin test for tracing TB contacts. Am. J. Respir. Crit. Care Med. 175 (2007) 618-627
3. Barnes P.F., Lu S., Abrams J.S., Wang E., Yamamura M., and Modlin R.L. Cytokine production at the site of disease in human tuberculosis. Infect. Immun. 61 (1993) 3482-3489
4. Brock I., Weldingh K., Leyten E.M., Arend S.M., Ravn P., and Andersen P. Specific T-cell epitopes for immunoassay-based diagnosis of Mycobacterium tuberculosis infection. J. Clin. Microbiol. 42 (2004) 2379-2387
5. Connell T.G., Ritz N., Paxton G.A., Buttery J.P., Curtis N., and Ranganathan S.C. A three-way comparison of tuberculin skin testing, QuantiFERON-TB gold and T-SPOT.TB in children. PLoS ONE e2624 (2008) 3
6. Chee C.B., Barkham T.M., Khinmar K.W., Gan S.H., and Wang Y.T. Quantitative T-cell interferon-gamma responses to Mycobacterium tuberculosis-specific antigens in active and latent tuberculosis. Eur. J. Clin. Microbiol. Infect. Dis. 28 (2008) 667-670
7. Chee C.B., Gan S.H., Khinmar K.W., Barkham T.M., Koh C.K., Liang S., and Wang Y.T. Comparison of sensitivities of two commercial gamma interferon release assays for pulmonary tuberculosis. J. Clin. Microbiol. 46 (2008) 1935-1940
8. Detjen A.K., Keil T., Roll S., Hauer B., Mauch H., Wahn U., and Magdorf K. Interferon-gamma release assays improve the diagnosis of tuberculosis and nontuberculous mycobacterial disease in children in a country with a low incidence of tuberculosis. Clin. Infect. Dis. 45 (2007) 322-328
9. Dinnes J., Deeks J., Kunst H., Gibson A., Cummins E., Waugh N., Drobniewski F., and Lalvani A. A systematic review of rapid diagnostic tests for the detection of tuberculosis infection. Health Technol. Assess. 11 (2007) 1-196
10. Djoba Siawaya J.F., Ruhwald M., Eugen-Olsen J., and Walzl G. Correlates for disease progression and prognosis during concurrent HIV/TB infection. Int. J. Infect. Dis. 11 (2007) 289-299
11. Doherty T.M., Demissie A., Olobo J., Wolday D., Britton S., Eguale T., Ravn P., and Andersen P. Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients. J. Clin. Microbiol. 40 (2002) 704-706
12. Dominguez J., Ruiz-Manzano J., De Souza-Galvao M., Latorre I., Mila C., Blanco S., Jimenez M.A., Prat C., Lacoma A., Altet N., and Ausina V. Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis. Clin. Vaccine Immunol. 15 (2008) 168-171
13. Domínguez J., De Souza-Galvao M., Ruiz-Manzano J., Latorre I., Prat C., Lacoma A., Milà C., Jiménez M.A., Blanco S., Maldonado J., Altet N., and Ausina V. T-cell responses to the Mycobacterium tuberculosis-specific antigens in active tuberculosis patients at the beginning, during, and after antituberculosis treatment. Diagn. Microbiol. Infect. Dis. 63 (2009) 43-51
14. Domínguez J., Latorre I., Altet N., Mateo L., De Souza-Galvao M., Ruiz-Manzano J., and Ausina V. Interferon-gamma-release assays to diagnose TB infection in immunocompromised individual. Expert Rev. Respir. Med. 3 (2009) 309-327
15. Dosanjh D.P., Hinks T.S., Innes J.A., Deeks J.J., Pasvol G., Hackforth S., Varia H., Millington K.A., Gunatheesan R., Guyot-Revol V., and Lalvani A. Improved diagnostic evaluation of suspected tuberculosis. Ann. Intern. Med. 148 (2008) 325-336
16. Dye C., Maher D., Weil D., Espinal M., and Raviglione M. Targets for global tuberculosis control. Int. J. Tuberc. Lung Dis. 10 (2006) 460-462
17. Ewer K., Deeks J., Alvarez L., Bryant G., Waller S., Andersen P., Monk P., and Lalvani A. Comparison of T-cell-based assay with tuberculin skin test for diagnosis of Mycobacterium tuberculosis infection in a school tuberculosis outbreak. Lancet 361 (2003) 1168-1173
18. Ferrara G., Losi M., D'Amico R., Roversi P., Piro R., Meacci M., Meccugni B., Dori I.M., Andreani A., Bergamini B.M., Mussini C., Rumpianesi F., Fabbri L.M., and Richeldi L. Use in routine clinical practice of two commercial blood tests for diagnosis of infection with Mycobacterium tuberculosis: a prospective study. Lancet 367 (2006) 1328-1334
19. Fox A., Jeffries D.J., Hill P.C., Hammond A.S., Lugos M.D., Jackson-Sillah D., Donkor S.A., Owiafe P.K., McAdam K.P., and Brookes R.H. ESAT-6 and CFP-10 can be combined to reduce the cost of testing for Mycobacterium tuberculosis infection, but CFP-10 responses associate with active disease. Trans. R. Soc. Trop. Med. Hyg. 101 (2007) 691-698
20. Goletti D., Vincenti D., Carrara S., Butera O., Bizzoni F., Bernardini G., Amicosante M., and Girardi E. Selected RD1 peptides for active tuberculosis diagnosis: comparison of a gamma interferon whole-blood enzyme-linked immunosorbent assay and an enzyme-linked immunospot assay. Clin. Diagn. Lab. Immunol. 12 (2005) 1311-1316
21. Goletti D., Carrara S., Vincenti D., Saltini C., Rizzi E.B., Schinina V., Ippolito G., Amicosante M., and Girardi E. Accuracy of an immune diagnostic assay based on RD1 selected epitopes for active tuberculosis in a clinical setting: a pilot study. Clin. Microbiol. Infect. 12 (2006) 544-550
22. Goletti D., Carrara S., Mayanja-Kizza H., Baseke J., Mugerwa M.A., Girardi E., and Toossi Z. Response to M. tuberculosis selected RD1 peptides in Ugandan HIV-infected patients with smear positive pulmonary tuberculosis: a pilot study. BMC Infect. Dis. 8 (2008) 11
23. Goletti D., Stefania C., Butera O., Amicosante M., Ernst M., Sauzullo I., Vullo V., Cirillo D., Borroni E., Markova R., Drenska R., Dominguez J., Latorre I., Angeletti C., Navarra A., Petrosillo N., Lauria F.N., Ippolito G., Migliori G.B., Lange C., and Girardi E. Accuracy of immunodiagnostic tests for active tuberculosis using single and combined results: a multicenter TBNET-Study. PLoS ONE e3417 (2008) 3
24. Hill P.C., Fox A., Jeffries D.J., Jackson-Sillah D., Lugos M.D., Owiafe P.K., Donkor S.A., Hammond A.S., Corrah T., Adegbola R.A., McAdam K.P., and Brookes R.H. Quantitative T cell assay reflects infectious load of Mycobacterium tuberculosis in an endemic case contact model. Clin. Infect. Dis. 40 (2005) 273-278
25. Hirsch C.S., Toossi Z., Othieno C., Johnson J.L., Schwander S.K., Robertson S., Wallis R.S., Edmonds K., Okwera A., Mugerwa R., Peters P., and Ellner J.J. Depressed T-cell interferon-gamma responses in pulmonary tuberculosis: analysis of underlying mechanisms and modulation with therapy. J. Infect. Dis. 180 (1999) 2069-2073
26. Horsburgh Jr. C.R. Priorities for the treatment of latent tuberculosis infection in the United States. N. Engl. J. Med. 350 (2004) 2060-2067
27. Huebner R.E., Schein M.F., and Bass Jr. J.B. The tuberculin skin test. Clin. Infect. Dis. 17 (1993) 968-975
28. Jafari C., Ernst M., Strassburg A., Greinert U., Kalsdorf B., Kirsten D., and Lange C. Local immunodiagnosis of pulmonary tuberculosis by enzyme-linked immunospot. Eur. Respir. J. 31 (2008) 261-265
29. Janssens J.P., Roux-Lombard P., Perneger T., Metzger M., Vivien R., and Rochat T. Quantitative scoring of an interferon-gamma assay for differentiating active from latent tuberculosis. Eur. Respir. J. 30 (2007) 722-728
30. Kang Y.A., Lee H.W., Hwang S.S., Um S.W., Han S.K., Shim Y.S., and Yim J.J. Usefulness of whole-blood interferon-{gamma} assay and interferon-{gamma} enzyme-linked immunospot assay in the diagnosis of active pulmonary tuberculosis. Chest 132 (2007) 959-965
31. Kobashi Y., Mouri K., Yagi S., Obase Y., Miyashita N., and Oka M. Transitional changes in T-cell responses to Mycobacterium tuberculosis-specific antigens during treatment. J. Infect. 58 (2008) 197-204
32. Lalvani A. Diagnosing tuberculosis infection in the 21st century: new tools to tackle an old enemy. Chest 131 (2007) 1898-1906
33. Lalvani A., Pathan A.A., McShane H., Wilkinson R.J., Latif M., Conlon C.P., Pasvol G., and Hill A.V. Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells. Am. J. Respir. Crit. Care Med. 163 (2001) 824-828
34. Latorre I., De Souza-Galvao M., Ruiz-Manzano J., Lacoma A., Prat C., Altet N., Ausina V., and Dominguez J. Evaluating the non-tuberculous mycobacteria effect in the tuberculosis infection diagnosis. Eur. Respir. J. 34 (2009) 10.1183/09031936.0196608
35. Lee J.Y., Choi H.J., Park I.N., Hong S.B., Oh Y.M., Lim C.M., Lee S.D., Koh Y., Kim W.S., Kim D.S., Kim W.D., and Shim T.S. Comparison of two commercial interferon-gamma assays for diagnosing Mycobacterium tuberculosis infection. Eur. Respir. J. 28 (2006) 24-30
36. Liebeschuetz S., Bamber S., Ewer K., Deeks J., Pathan A.A., and Lalvani A. Diagnosis of tuberculosis in South African children with a T-cell-based assay: a prospective cohort study. Lancet 364 (2004) 2196-2203
37. Losi M., Bossink A., Codecasa L., Jafari C., Ernst M., Thijsen S., Cirillo D., Ferrarese M., Greinert U., Fabbri L.M., Richeldi L., and Lange C. Use of a T-cell interferon-{gamma} release assay for the diagnosis of tuberculous pleurisy. Eur. Respir. J. 30 (2007) 1173-1179
38. Menzies D. Using tests for latent tuberculous infection to diagnose active tuberculosis: can we eat our cake and have it too?. Ann. Intern. Med. 148 (2008) 398-399
39. Menzies D., Pai M., and Comstock G. Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research. Ann. Intern. Med. 146 (2007) 340-354
40. Migliori G.B., Hopewell P.C., Blasi F., Spanevello A., and Raviglione M.C. Improving the TB case management: the International Standards for Tuberculosis Care. Eur. Respir. J. 28 (2006) 687-690
41. Mori T., Sakatani M., Yamagishi F., Takashima T., Kawabe Y., Nagao K., Shigeto E., Harada N., Mitarai S., Okada M., Suzuki K., Inoue Y., Tsuyuguchi K., Sasaki Y., Mazurek G.H., and Tsuyuguchi I. Specific detection of tuberculosis infection: an interferon-gamma-based assay using new antigens. Am. J. Respir. Crit. Care Med. 170 (2004) 59-64
42. Pai M., Zwerling A., and Menzies D. Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update. Ann. Intern. Med. 149 (2008) 177-184
43. Pathan A.A., Wilkinson K.A., Klenerman P., McShane H., Davidson R.N., Pasvol G., Hill A.V., and Lalvani A. Direct ex vivo analysis of antigen-specific IFN-gamma-secreting CD4 T cells in Mycobacterium tuberculosis-infected individuals: associations with clinical disease state and effect of treatment. J. Immunol. 167 (2001) 5217-5225
44. Rangaka M.X., Wilkinson K.A., Seldon R., Van Cutsem G., Meintjes G.A., Morroni C., Mouton P., Diwakar L., Connell T.G., Maartens G., and Wilkinson R.J. Effect of HIV-1 infection on T-Cell-based and skin test detection of tuberculosis infection. Am. J. Respir. Crit. Care Med. 175 (2007) 514-520
45. Richeldi L. An update on the diagnosis of tuberculosis infection. Am. J. Respir. Crit. Care Med. 174 (2006) 736-742
46. Ruhwald M., Bjerregaard-Andersen M., Rabna P., Kofoed K., Eugen-Olsen J., and Ravn P. CXCL10/IP-10 release is induced by incubation of whole blood from tuberculosis patients with ESAT-6, CFP10 and TB7.7. Microbes Infect. 9 (2007) 806-812
47. Ruiz-Manzano J., Blanquer R., Calpe J.L., Caminero J.A., Caylà J., Domínguez J., García J.M., and Vidal R. SEPAR Guidelines. Diagnostic and treatment of tuberculosis. Arch. Bronconeumol. 44 (2008) 551-566
48. Soysal A., Torun T., Efe S., Gencer H., Tahaoglu K., and Bakir M. Evaluation of cut-off values of interferon-gamma-based assays in the diagnosis of M. tuberculosis infection. Int. J. Tuberc. Lung Dis. 12 (2008) 50-56
49. Valdes L., Alvarez D., San Jose E., Penela P., Valle J.M., Garcia-Pazos J.M., Suarez J., and Pose A. Tuberculous pleurisy: a study of 254 patients. Arch. Intern. Med. 158 (1998) 2017-2021
50. Vincenti D., Carrara S., De Mori P., Pucillo L.P., Petrosillo N., Palmieri F., Armignacco O., Ippolito G., Girardi E., Amicosante M., and Goletti D. Identification of early secretory antigen target-6 epitopes for the immunodiagnosis of active tuberculosis. Mol. Med. 9 (2003) 105-111
51. Whittaker E., Gordon A., and Kampmann B. Is IP-10 a better biomarker for active and latent tuberculosis in children than IFNgamma?. PLoS ONE 3 (2008) e3901
52. Wilkinson K.A., Wilkinson R.J., Pathan A., Ewer K., Prakash M., Klenerman P., Maskell N., Davies R., Pasvol G., and Lalvani A. Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis. Clin. Infect. Dis. 40 (2005) 184-187