Role of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: Wild type versus mutant p53-R175H

FEBS Letters

Volumn 583, Issue 22, 2009, Pages 3557-3562

  Fanucchi, Stephanie ^a   Veale, Robin B ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

Apoptosis; Esophageal carcinoma; Focal adhesion kinase; p53

Indexed keywords

ARGININE; CASPASE 3; FOCAL ADHESION KINASE; HISTIDINE; MUTANT PROTEIN; PROTEIN P53; SERINE; STAUROSPORINE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVATION; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; WILD TYPE;

AMINO ACID SUBSTITUTION; APOPTOSIS; CASPASE 3; CELL ADHESION; CELL LINE, TUMOR; CELL NUCLEUS; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FOCAL ADHESION KINASE 1; HUMANS; IMMUNOBLOTTING; MUTATION; PHOSPHORYLATION; PROTEIN TRANSPORT; SERINE; STAUROSPORINE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 71749089995     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.10.059     Document Type: Article

References (29)

1. Cohen L.A., and Guan J.L. Mechanisms of focal adhesion kinase regulation. Curr. Cancer. Drug Targets 5 (2005) 629-643
2. Mitra S.K., Hanson D.A., and Schlaepfer D.D. Focal adhesion kinase: in command and control of cell motility. Nat. Rev. Mol. Cell Biol. 6 (2005) 56-68
3. Schneider G.B., Kurago Z., Zaharias R., Gruman L.M., Schaller M.D., and Hendrix M.J.C. Elevated focal adhesion kinase expression facilitates oral tumor cell invasion. Cancer 95 (2002) 2508-2515
4. Lark A.L., Livasy C.A., Dressler L., Moore D.T., Millikan R.C., Geradts J., Iacocca M., Cowan D., Little D., and Craven R.J. High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype. Mod. Path. 18 (2005) 1289-1294
5. Miyazaki T., Kato H., Nakajima M., Sohda M., Fukai Y., Masuda N., Manda R., Fukuchi M., Tsukada K., and Kuwano H. FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma. Br. J. Cancer 89 (2003) 140-145
6. Golubovskaya V.M., Finch R., Kweh F., Massoll N.A., Campbell-Thompson M., Wallace M.R., and Cance W.G. P53 regulates FAK expression in human tumor cells. Mol. Carcinog. 47 (2008) 373-382
7. Golubovskaya V.M., Finch R., and Cance W.G. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. J. Biol. Chem. 280 (2005) 25008-25021
8. Ilic D., Almeida E.A.C., Schlaepfer D.D., Dazin P., Aizawa S., and Damsky C.H. Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis. J. Cell Biol. 143 (1998) 547-560
9. Zhang Y., Lu H., Dazin P., and Kapila Y. Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase. J. Biol. Chem. 279 (2004) 48342-48349
10. Lim S.T., Chen X.L., Lim Y., Hanson D.A., Vo T.T., Howerton K., Larocque N., Fisher S.J., Schlaepfer D.D., and Ilic D. Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol. Cell 29 (2008) 9-22
11. Beviglia L., Golubovskaya V., Xu L., Yang X., Craven R.J., and Cance W.G. Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding, detachment and apoptosis. Biochem. J. 373 (2003) 201-210
12. Golubovskaya V.M., Conway-Dorsey K., Edmiston S.N., Tse C.-K., Lark A.A., Livasy C.A., Moore D., Millikan R.C., and Cance W.G. FAK overexpression and p53 mutations are highly correlated in human breast cancer. Int. J. Cancer 125 (2009) 1735-1738
13. Blandino G., Levine A.J., and Oren M. Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy. Oncogene 18 (1999) 477-485
14. Tsang W., Ho F.Y.F., Fung K., Kong S., and Kwok T. P53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int. J. Cancer 114 (2005) 331-336
15. Aylon Y., and Oren M. Living with p53, dying of p53. Cell 130 (2007) 597-601
16. Shimizu H., Saliba D., Wallace M., Finlan L., Langridge-Smith P.R.R., and Hupp T.R. Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo. Biochem. J. 397 (2006) 355-367
17. Kurihara A., Nagoshi H., Yabuki M., Okuyama R., Obinata M., and Ikawa S. Ser46 phosphorylation of p53 is not always sufficient to induce apoptosis: multiple mechanism of regulation of p53-dependent apoptosis. Gene Cell 12 (2007) 853-861
18. Thompson R., Tovar C., Yang H., Carvajal D., Vu B.T., Xu Q., Wahl G.M., Heimbrook D.C., and Vassilev L.T. Phosphorylation of p53 on key serine residues is dispensable for transcriptional activation and apoptosis. J. Biol. Chem. 17 (2004) 53015-53022
19. Oda K., Arakawa H., Tanaka T., Matsuda K., Tanikawa C., Mori T., Nishimori H., Tamai K., Tokino T., Nakamura Y., and Taya Y. P53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by ser-46-phosphorylated p53. Cell 102 (2000) 849-862
20. Feng L., Hollstein M., and Xu Y. Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence. Cell Cycle 5 (2006) 2812-2819
21. Xue L.Y., Hu N., Song Y.M., Zou S.M., Shou J.Z., Qian L.X., Ren L.Q., Lin D.M., Tong T., He Z.G., Zhan Q.M., Taylor P.R., and Lu N. Tissue microarray analysis reveals a tight correlation between protein expression pattern and progression of esophageal squamous cell carcinoma. BMC Cancer 6 (2006) 296
22. Leu C.M., Chang C., and Hu C. Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway. Oncogene 19 (2000) 1665-1675
23. Veale R., and Thornley A. Increased single class low-affinity EGF receptors expressed by human oesophageal squamous carcinoma cell lines. S. Afr. Med. J. Sci 85 (1989) 375-379
24. Bey E., Alexander J., Whitcutt J.M., Hunt J.A., and Gear J.H.S. Carcinoma of the esophagus in Africans: establishment of a continuously growing cell line from a tumor specimen. In Vitro 12 (1976) 107-114
25. Anselmi C., Ettorre A., Andreassi M., Centini M., Neri P., and Di Stefano A. In vitro induction of apoptosis vs. necrosis by widely used preservatives: 2-phenoxyethanol, a mixture of isothiazolinones, imidazolidinyl urea and 1,2-pentanediol. Biochem. Pharmacol. 63 (2002) 437-453
26. Mooney L.M., Al-Sakkaf K.A., Brown B.L., and Dobson P.R.M. Apoptotic mechanisms in T47D and MCF-7 human breast cancer cells. Br. J. Cancer 87 (2002) 909-917
27. Ossovskaya V., Lim S., Ota N., Schlaepfer D.D., and Ilic D. FAK nuclear export signal sequences. FEBS Lett. 582 (2008) 2402-2406
28. Gervais F.G., Thornberry N.A., Ruffolo S.C., Nicholson D.W., and Roy S. Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide. J. Biol. Chem. 273 (1998) 17102-17108
29. Ichwan S.J., Yamada S., Sumrejkanchanakji P., Irabhim-Auerkari E., Eto K., and Ikeda M.A. Defect in Ser46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells. Oncogene 25 (2006) 1216-1224