Separation of human serum albumin and human immunoglobulins using carrier phase ultrafiltration

Biotechnology Progress

Volumn 20, Issue 4, 2004, Pages 1103-1112

  Wan, Yinhua ^a   Ghosh, Raja ^b   Cui, Zhanfeng ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; OPTIMIZATION; PH EFFECTS; ULTRAFILTRATION;

IMMUNOGOBULINS; SERUM;

BIOTECHNOLOGY;

IMMUNOGLOBULIN G; SERUM ALBUMIN;

ARTICLE; HUMAN; ISOLATION AND PURIFICATION; METHODOLOGY; OSMOLARITY; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; ULTRAFILTRATION;

ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; OSMOLAR CONCENTRATION; SERUM ALBUMIN; ULTRAFILTRATION;

EID: 4043176173     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp0343716     Document Type: Article

References (22)

1. Saksena, S.; Zydney, A. L. Effect of solution pH and ionic strength on the separation of albumin from immunoglobulins (IgG) by selective filtration. Biotechnol. Bioeng. 1994, 43, 960-968.
2. Ghosh, R.; Cui, Z. F. Fractionation of BSA and lysozyme using ultrafiltration: Effect of pH and membrane surface pretreatment. J. Membr. Sci. 1998, 139, 17-28.
3. Zhang, L.; Spencer, H. G. Selective separation of proteins by microfiltration with formed-in-place membranes. Desalination 1993, 90, 137-146.
4. van Eijndhoven, R. H. C. M.; Saksena, S.; Zydney, A. L. Protein fractionation using electrostatic interactions in membrane filtration. Biotechnol. Bioeng. 1995, 48, 406-414.
5. Opong, W. S.; Zydney, A. L. Diffusive and convective protein transport through asymmetric membranes. AIChE J. 1991, 37, 1497-1510.
6. Fane, A. G.; Fell, C. J. D.; Suki, A. The effect of pH and ionic environment on the ultrafiltration of protein solutions with retentive membranes. J. Membr. Sci. 1983, 16, 195-210.
7. Ehsani, N.; Parkkinen, S.; Nystrom, M. Fractionation of natural and model egg white protein solution with modified and unmodified polysulfone UF membranes. J. Membr. Sci. 1997, 123, 105-119.
8. Li, Q. Y.; Cui, Z. F.; Pepper, D. S. Fractionation of HSA and IgG by gas sparged ultrafiltration. J. Membr. Sci. 1997, 136, 181-190.
9. Ghosh, R. Fractionation of biological macromolecules using carrier phase ultrafiltration. Biotechnol. Bioeng. 2001, 74, 1-11.
10. Ghosh, R.; Cui, Z. F. Analysis of protein transport and polarisation through membrane using pulsed sample injection technique. J. Membr. Sci. 2000, 175, 75-84.
11. Wan, Y.; Ghosh, R.; Cui, Z. F. High-resolution plasma protein fractionation using ultrafiltration. Desalination 2002, 144, 301-306.
12. Ghosh, R.; Wan, Y.; Cui, Z. F.; Hale, G. Parameter scanning ultrafiltration: Rapid optimization of protein separation. Biotechnol. Bioeng. 2003, 81, 673-682.
13. Ghosh, R. Study of membrane fouling by BSA using pulsed injection technique, J. Membr. Sci. 2002, 195, 117-126.
14. Foster, J. F. Some aspects of the structure and conformational properties of serum albumin. In Albumin Structure, Function and Uses; Rosenoer, V. M., Oratz, M., Rothschild, M. A., Eds.; Pergamon: Oxford, 1977; pp 53-84.
15. Carter, D. C.; Ho, J. X. Structure of serum albumin. Adv. Protein Chem. 1994, 45, 153-203.
16. Kelly, B. D.; Petrone, J. T. Virus removal by tangential-flow filtration for protein therapeutics. In Membrane Separation in Biotechnology, 2nd ed.; Wang, W. K., Ed.; Marcel Dekker: New York, 2001; pp 351-396.
17. Nel, R. G.; Oppennheim, S. F.; Rodgers, V. G. J. Effects of solution properties on solute and permeate flux in bovine serum albumin-IgG ultrafiltration. Biotechnol. Prog. 1994, 10, 539-542.
18. Miller, K. D.; Weitzel, S.; Rodgers, V. G. J. Reduction of membrane fouling in the presence of high polarization resistance. J. Membr. Sci. 1993, 76, 77-83.
19. Saksena, S.; Zydney, A. L. Influence of protein-protein interactions on bulk mass transport during ultrafiltration. J. Membr. Sci. 1997, 125, 93-108.
20. Higuchi, A.; Mishima, S,; Nakagawa, T. Separation of proteins by surface modified polysulfone membranes. J. Membr. Sci. 1991, 57, 175-185.
21. Ghosh, R.; Cui, Z. F. Simulation study of the fractionation of proteins using ultrafiltration. J. Membr. Sci. 2000, 180, 29-36.
22. Xu, Y.; Sirkar, K. K. Protein mass transfer enhancement in the membrane filtration-cum-adsorption process. J. Membr. Sci. 2003, 221, 79-87.