-
1
-
-
0034077041
-
Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system
-
Abeliovich A., Schmitz Y., Farinas I., Choi-Lundberg D., Ho W.H., Castillo P.E., Shinsky N., Verdugo J.M., Armanini M., Ryan A., Hynes M., Phillips H., Sulzer D., and Rosenthal A. Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25 (2000) 239-252
-
(2000)
Neuron
, vol.25
, pp. 239-252
-
-
Abeliovich, A.1
Schmitz, Y.2
Farinas, I.3
Choi-Lundberg, D.4
Ho, W.H.5
Castillo, P.E.6
Shinsky, N.7
Verdugo, J.M.8
Armanini, M.9
Ryan, A.10
Hynes, M.11
Phillips, H.12
Sulzer, D.13
Rosenthal, A.14
-
2
-
-
16444371982
-
Expression of α-synuclein in different brain parts of adult and aged rats
-
Adamczyk A., Solecka J., and Strosznajder J.B. Expression of α-synuclein in different brain parts of adult and aged rats. J. Physiol. Pharmacol. 56 (2005) 29-37
-
(2005)
J. Physiol. Pharmacol.
, vol.56
, pp. 29-37
-
-
Adamczyk, A.1
Solecka, J.2
Strosznajder, J.B.3
-
3
-
-
77950521882
-
-
Al-Wandi, A., Ninkina, N., Millership, S., Williamson, S.J., Jones, P.A., Buchman, V.L., in press. Absence of α-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice. Neurobiol. Aging.10.1016/j.neurobiolaging.2008.11.001
-
Al-Wandi, A., Ninkina, N., Millership, S., Williamson, S.J., Jones, P.A., Buchman, V.L., in press. Absence of α-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice. Neurobiol. Aging.10.1016/j.neurobiolaging.2008.11.001
-
-
-
-
4
-
-
33751118534
-
Age-associated increases of α-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: is this the target for Parkinson's disease?
-
Chu Y., and Kordower J.H. Age-associated increases of α-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: is this the target for Parkinson's disease?. Neurobiol. Dis. 25 (2007) 134-149
-
(2007)
Neurobiol. Dis.
, vol.25
, pp. 134-149
-
-
Chu, Y.1
Kordower, J.H.2
-
5
-
-
0032102455
-
The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
-
Clayton D.F., and George J.M. The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci. 21 (1998) 249-254
-
(1998)
Trends Neurosci.
, vol.21
, pp. 249-254
-
-
Clayton, D.F.1
George, J.M.2
-
6
-
-
0035834360
-
Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct
-
Conway K.A., Rochet J.C., Bieganski R.M., and Lansbury P.T. Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct. Science 294 (2001) 1346-1349
-
(2001)
Science
, vol.294
, pp. 1346-1349
-
-
Conway, K.A.1
Rochet, J.C.2
Bieganski, R.M.3
Lansbury, P.T.4
-
7
-
-
33947127695
-
Long-term consequences of human α-synuclein overexpression in the primate ventral midbrain
-
Eslamboli A., Romero-Ramos M., Burger C., Björklund T., Muzyczka N., Mandel R.J., Baker H., Ridley R.M., and Kirik D. Long-term consequences of human α-synuclein overexpression in the primate ventral midbrain. Brain 130 (2007) 799-815
-
(2007)
Brain
, vol.130
, pp. 799-815
-
-
Eslamboli, A.1
Romero-Ramos, M.2
Burger, C.3
Björklund, T.4
Muzyczka, N.5
Mandel, R.J.6
Baker, H.7
Ridley, R.M.8
Kirik, D.9
-
8
-
-
10744227740
-
Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications
-
Farrer M., Kachergus J., Forno L., Lincoln S., Wang D.S., Hulihan M., Maraganore D., Gwinn-Hardy K., Wszolek Z., Dickson D., and Langston J.W. Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications. Ann. Neurol. 55 (2004) 174-179
-
(2004)
Ann. Neurol.
, vol.55
, pp. 174-179
-
-
Farrer, M.1
Kachergus, J.2
Forno, L.3
Lincoln, S.4
Wang, D.S.5
Hulihan, M.6
Maraganore, D.7
Gwinn-Hardy, K.8
Wszolek, Z.9
Dickson, D.10
Langston, J.W.11
-
9
-
-
1542613781
-
α-Synuclein A53T substitution associated with Parkinson's disease also marks the divergence of Old World and New World primates
-
Hamilton B.A. α-Synuclein A53T substitution associated with Parkinson's disease also marks the divergence of Old World and New World primates. Genomics 83 (2004) 739-742
-
(2004)
Genomics
, vol.83
, pp. 739-742
-
-
Hamilton, B.A.1
-
10
-
-
0026543770
-
The relationships between aging, monoamine oxidase, striatal dopamine and the effects of MPTP in C57BL/6 mice: a critical reassessment
-
Irwin I., Finnegan K.T., DeLanney L.E., Di Monte D., and Langston J.W. The relationships between aging, monoamine oxidase, striatal dopamine and the effects of MPTP in C57BL/6 mice: a critical reassessment. Brain Res. 572 (1992) 224-231
-
(1992)
Brain Res.
, vol.572
, pp. 224-231
-
-
Irwin, I.1
Finnegan, K.T.2
DeLanney, L.E.3
Di Monte, D.4
Langston, J.W.5
-
11
-
-
0031990490
-
Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
-
Kruger R., Kuhn W., Muller T., Woitalla D., Graeber M., Kosel S., Przuntek H., Eppelen J.T., Schols L., and Reiss O. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat. Genet. 18 (1998) 106-108
-
(1998)
Nat. Genet.
, vol.18
, pp. 106-108
-
-
Kruger, R.1
Kuhn, W.2
Muller, T.3
Woitalla, D.4
Graeber, M.5
Kosel, S.6
Przuntek, H.7
Eppelen, J.T.8
Schols, L.9
Reiss, O.10
-
12
-
-
7244243876
-
Stabilization of α-synuclein protein with aging and familial Parkinson's disease-linked A53T mutation
-
Li W., Lesuisse C., Xu Y., Troncoso J.C., Price D.L., and Lee M.K. Stabilization of α-synuclein protein with aging and familial Parkinson's disease-linked A53T mutation. J. Neurosci. 24 (2004) 7400-7409
-
(2004)
J. Neurosci.
, vol.24
, pp. 7400-7409
-
-
Li, W.1
Lesuisse, C.2
Xu, Y.3
Troncoso, J.C.4
Price, D.L.5
Lee, M.K.6
-
13
-
-
33750597306
-
Levels of mRNA coding for α-, β-, and γ-synuclein in the brains of newborn, juvenile and adult rats
-
Malatynska E., Pinhasov A., Crooke J., Horowitz D., Brenneman D.E., and Ilyin S.E. Levels of mRNA coding for α-, β-, and γ-synuclein in the brains of newborn, juvenile and adult rats. J. Mol. Neurosci. 29 (2006) 269-277
-
(2006)
J. Mol. Neurosci.
, vol.29
, pp. 269-277
-
-
Malatynska, E.1
Pinhasov, A.2
Crooke, J.3
Horowitz, D.4
Brenneman, D.E.5
Ilyin, S.E.6
-
14
-
-
38849174979
-
Dopamine-modified α-synuclein blocks chaperone-mediated autophagy
-
Martinez-Vicente M., Talloczy Z., Kaushik S., Massey A.A., Mazzulli J., Mosharov E.V., Hodara R., Fredenburg R., Wu D.C., Follenzi A., Dauer W., Przedborski S., Ischiropoulos H., Lansbury P.T., Sulzer D., and Cuervo A.M. Dopamine-modified α-synuclein blocks chaperone-mediated autophagy. J. Clin. Invest. 118 (2008) 777-788
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 777-788
-
-
Martinez-Vicente, M.1
Talloczy, Z.2
Kaushik, S.3
Massey, A.A.4
Mazzulli, J.5
Mosharov, E.V.6
Hodara, R.7
Fredenburg, R.8
Wu, D.C.9
Follenzi, A.10
Dauer, W.11
Przedborski, S.12
Ischiropoulos, H.13
Lansbury, P.T.14
Sulzer, D.15
Cuervo, A.M.16
-
15
-
-
33645829816
-
Consequences of the selective blockage of chaperone-mediated autophagy
-
Massey A.C., Kaushik S., Sovak G., Kiffin R., and Cuervo A.M. Consequences of the selective blockage of chaperone-mediated autophagy. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 5805-5810
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 5805-5810
-
-
Massey, A.C.1
Kaushik, S.2
Sovak, G.3
Kiffin, R.4
Cuervo, A.M.5
-
16
-
-
70349481750
-
Enhanced α-synuclein expression in human neurodegenerative diseases: pathogenetic and therapeutic implications
-
McCormack A.L., and Di Monte D.A. Enhanced α-synuclein expression in human neurodegenerative diseases: pathogenetic and therapeutic implications. Curr. Protein Pept. Sci. 10 (2009) 476-482
-
(2009)
Curr. Protein Pept. Sci.
, vol.10
, pp. 476-482
-
-
McCormack, A.L.1
Di Monte, D.A.2
-
17
-
-
1642523445
-
Aging of the nigrostriatal system in the squirrel monkey
-
McCormack A.L., Di Monte D.A., Delfani K., Irwin I., DeLanney L.E., Langston W.J., and Janson A.A. Aging of the nigrostriatal system in the squirrel monkey. J. Comp. Neurol. 471 (2004) 387-395
-
(2004)
J. Comp. Neurol.
, vol.471
, pp. 387-395
-
-
McCormack, A.L.1
Di Monte, D.A.2
Delfani, K.3
Irwin, I.4
DeLanney, L.E.5
Langston, W.J.6
Janson, A.A.7
-
18
-
-
0032960760
-
Developmental expression of α-synuclein in rat hippocampus and cerebral cortex
-
Petersen K., Olesen O.F., and Mikkelsen J.D. Developmental expression of α-synuclein in rat hippocampus and cerebral cortex. Neuroscience 91 (1999) 651-659
-
(1999)
Neuroscience
, vol.91
, pp. 651-659
-
-
Petersen, K.1
Olesen, O.F.2
Mikkelsen, J.D.3
-
19
-
-
0030744876
-
Mutation in the α-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnston W.G., Lazzarini A.M., Duvoisin R.C., Di Iorio G., Golbi L.I., and Nussbaum R.L. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276 (1997) 2045-2047
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
Stenroos, E.S.11
Chandrasekharappa, S.12
Athanassiadou, A.13
Papapetropoulos, T.14
Johnston, W.G.15
Lazzarini, A.M.16
Duvoisin, R.C.17
Di Iorio, G.18
Golbi, L.I.19
Nussbaum, R.L.20
more..
-
20
-
-
27744450270
-
α-Synuclein expression in the substantia nigra of MPTP-lesioned non-human primates
-
Purisai M.G., McCormack A.L., Langston W.J., Johnston L.C., and Di Monte D.A. α-Synuclein expression in the substantia nigra of MPTP-lesioned non-human primates. Neurobiol. Dis. 20 (2005) 898-906
-
(2005)
Neurobiol. Dis.
, vol.20
, pp. 898-906
-
-
Purisai, M.G.1
McCormack, A.L.2
Langston, W.J.3
Johnston, L.C.4
Di Monte, D.A.5
-
21
-
-
0242300619
-
α-Synuclein locus triplication causes Parkinson's disease
-
Singleton A.B., Farrer M., Johnson J., Singleton A., Hague S., Kachergus J., Hulihan M., Peuralinna T., Dutra A., Nussbaum R., Lincoln S., Crawley A., Hanson M., Maraganore D., Adler C., Cookson M.R., Muenter M., Baptista M., Miller D., Blancato J., Hardy J., and Gwinn-Hardy K. α-Synuclein locus triplication causes Parkinson's disease. Science 302 (2003) 841
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
Lincoln, S.11
Crawley, A.12
Hanson, M.13
Maraganore, D.14
Adler, C.15
Cookson, M.R.16
Muenter, M.17
Baptista, M.18
Miller, D.19
Blancato, J.20
Hardy, J.21
Gwinn-Hardy, K.22
more..
-
22
-
-
0032568534
-
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
-
Spillantini M.G., Crowther R.A., Jakes R., Hasegawa M., and Goerdert M. α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 6469-6473
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Hasegawa, M.4
Goerdert, M.5
-
23
-
-
0042421940
-
Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype
-
Thiruchelvam M., McCormack A., Richfield E.K., Baggs R.B., Tank A.W., Di Monte D.A., and Cory-Slechta D.A. Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype. Eur. J. Neurosci. 18 (2003) 589-600
-
(2003)
Eur. J. Neurosci.
, vol.18
, pp. 589-600
-
-
Thiruchelvam, M.1
McCormack, A.2
Richfield, E.K.3
Baggs, R.B.4
Tank, A.W.5
Di Monte, D.A.6
Cory-Slechta, D.A.7
-
24
-
-
0031713491
-
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein
-
Tu P.H., Galvin J.E., Baba M., Giasson B., Tomita T., Leight S., Nakajo S., Iwatsubo T., Trojanowski J.Q., and Lee V.M. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein. Ann. Neurol. 44 (1998) 415-422
-
(1998)
Ann. Neurol.
, vol.44
, pp. 415-422
-
-
Tu, P.H.1
Galvin, J.E.2
Baba, M.3
Giasson, B.4
Tomita, T.5
Leight, S.6
Nakajo, S.7
Iwatsubo, T.8
Trojanowski, J.Q.9
Lee, V.M.10
-
25
-
-
10744230149
-
The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia
-
Zarranz J.J., Alegre J., Gomez-Esteban J.C., Lezcano E., Ros R., Ampuero I., Vidal L., Hoenicka J., Rodríguez O., Atares B., Llorens V., Gomez Tortosa E., del Ser T., Munoz D.G., and de Yerbenes J.G. The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol. 55 (2004) 164-173
-
(2004)
Ann. Neurol.
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
Vidal, L.7
Hoenicka, J.8
Rodríguez, O.9
Atares, B.10
Llorens, V.11
Gomez Tortosa, E.12
del Ser, T.13
Munoz, D.G.14
de Yerbenes, J.G.15
|