Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice

Cardiovascular Research

Volumn 84, Issue 2, 2009, Pages 292-299

  Zhuo, Ming Lei ^a   Huang, Yue ^a   Chen, Jing Zhou ^b   Sun, Li Hong ^a   Yang, Rui Feng ^a   Chen, Hou Zao ^a   Lv, Xiang ^a   Li, Hong Liang ^a   Wei, Yu Sheng ^a   Liu, Guang ^a   Zhang, Ran ^a   Ma, Tie Min ^c   Cai, Hua ^d   Hui, Ru Tai ^b   Liu, De Pei ^a   Liang, Chih Chuan ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b FUWAI HOSPITAL   (China)

^c PEKING UNIVERSITY   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Endothelium; Haemodynamics; Hypertension; Nitric oxide

Indexed keywords

BINDING PROTEIN; COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; BLOOD VESSEL TONE; CELL PROLIFERATION; CONTROL GROUP; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; EXPERIMENTAL MODEL; GENE; HEART; HUMAN; HUMAN CELL; HYPERTENSION; IC53 GENE; IN SITU HYBRIDIZATION; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYSTOLIC BLOOD PRESSURE; TRANSGENIC MOUSE; UPREGULATION; VASCULAR ENDOTHELIUM; VASODILATATION; WESTERN BLOTTING; WILD TYPE;

ANIMALS; ANTIGENS, CD; BLOOD PRESSURE; CADHERINS; CELLS, CULTURED; CLONING, MOLECULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENDOTHELIAL CELLS; ENDOTHELIN-1; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENOTYPE; HUMANS; HYPERTENSION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHENOTYPE; PROMOTER REGIONS, GENETIC; RNA INTERFERENCE; RNA, MESSENGER; SYSTOLE; VASODILATION; VASODILATOR AGENTS;

EID: 71549156556     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp204     Document Type: Article

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