Editorial: Ascorbic acid and tetrahydrobiopterin: Looking beyond nitric oxide bioavailability

Cardiovascular Research

Volumn 84, Issue 2, 2009, Pages 178-179

  Muller Delp, Judy M ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ASCORBIC ACID; CALCIUM; CALCIUM ION; CYCLOPIAZONIC ACID; HYDROGEN PEROXIDE; ION CHANNEL; NITRIC OXIDE; PROSTANOID; TETRAHYDROBIOPTERIN; 5,6,7,8-TETRAHYDROBIOPTERIN; BIOLOGICAL FACTOR; BIOPTERIN; DRUG DERIVATIVE; ENDOTHELIUM DEPENDENT HYPERPOLARIZATION FACTOR; ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION FACTOR; GAP JUNCTION PROTEIN; OXIDIZING AGENT; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; VASODILATOR AGENT;

CALCIUM CELL LEVEL; EDITORIAL; ENDOPLASMIC RETICULUM; GAP JUNCTION; PRIORITY JOURNAL; SMOOTH MUSCLE TONE; VASCULAR SMOOTH MUSCLE; VASODILATATION; ANIMAL; CELL JUNCTION; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; ILIAC ARTERY; METABOLISM; NOTE; SARCOPLASMIC RETICULUM;

ANIMALS; ASCORBIC ACID; BIOLOGICAL FACTORS; BIOPTERIN; CALCIUM; CONNEXINS; GAP JUNCTIONS; HUMANS; HYDROGEN PEROXIDE; ILIAC ARTERY; NITRIC OXIDE; OXIDANTS; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; VASODILATION; VASODILATOR AGENTS;

EID: 71549119182     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp307     Document Type: Editorial

References (15)

1. Drexler H. Nitric oxide and coronary endothelial dysfunction in humans. Cardiovasc Res 1999;43:572-579.
2. Gerhard M, Roddy MA, Creager SJ, Creager MA. Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension 1996;27:849-853.
3. Pannirselvam M, Verma S, Anderson TJ, Triggle CR. Cellular basis of endo-thelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db-/-) mice: role of decreased tetrahydrobiopterin bioavailability. Br J Pharmacol 2002;136:255-263.
4. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circulation Res 2000;87:840-844.
5. Heller R, Unbehaun A, Schellenberg B, Mayer B, Werner-Felmayer G, Werner ER. L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin. J Biol Chem 2001; 276:40-47
6. d'Uscio LV, Milstien S, Richardson D, Smith L, Katusic ZS. Long-term vitamin c treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circ Res 2003;92:88-95.
7. Gross SS, Jones CL, Hattori Y, Raman CS. Tetrahydrobiopterin: an essential cofactor of nitric oxide synthase with an elusive role. In: Ignarro LJ (ed), Nitric Oxide Biology and Pathobiology. San Diego, CA: Academic, 2000:167-185.
8. Eskurza I, Myerburgh LA, Kahn ZD, Seals DR. Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults. J Physiol 2005;568:1057-1065.
9. Shinozaki K, Nishio Y, Okamura T, Yoshida Y, Maegawa H, Kojima H et al. Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats. Circ Res 2000;87:566-573.
10. Moens AL, Kass DA. Tetrahydrobiopterin and cardiovascular disease. Arterioscler Thromb Vasc Biol 2006;26:2439-2444.
11. Garry A, Edwards DH, Fallis IF, Jenkins RL, Griffith TM. Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide. Cardiovasc Res 2009;84:218-226.
12. Edwards DH, Li Y, Griffith TM. Hydrogen peroxide potentiates the EDHF phenomenon by promoting endothelial Ca2+ mobilization. Arterioscler Thromb Vasc Biol 2008;28:1774-1781.
13. Park Y, Capobianco S, Gao X, Falck JR, Dellsperger KC, Zhang C. Role of EDHF in type 2 diabetes-induced endothelial dysfunction. Am J Physiol Heart Circ Physiol 2008;295:H1982-H1988.
14. Kajiya M, Hirota M, Inai Y, Kiyooka T, Morimoto T, Iwasaki T et al. Impaired NO-mediated vasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats. Am J Physiol Heart Circ Physiol 2007; 292:H2737-H2744.
15. Griffith TM, Chaytor AT, Bakker LM, Edwards DH. 5-Methyltetrahydrofolate and tetrahydrobiopterin can modulate electrotonically mediated endothelium-dependent vascular relaxation. Proc Natl Acad Sci USA 2005;102:7008-7013.