Missense mutations that cause Bruck syndrome affect enzymatic activity, folding, and oligomerization of lysyl hydroxylase 2

Journal of Biological Chemistry

Volumn 284, Issue 45, 2009, Pages 30917-30924

  Hyry, Marjo ^a   Lantto, Juha ^a   Myllyharju, Johanna ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

2-OXOGLUTARATE; BONE COLLAGEN; CATALYTIC PROPERTIES; CO-SUBSTRATE; COEXPRESSED; COLLAGEN FIBRILS; CONNECTIVE TISSUES; ENZYMATIC ACTIVITIES; FOLDING PROPERTIES; HYDROXYLASES; INSECT CELLS; MOLECULAR LEVELS; N-TERMINALS; POINT MUTATIONS; PROCOLLAGEN; RECOMBINANT POLYPEPTIDES; SKELETAL STRUCTURES; TELOPEPTIDES; WILD TYPES;

BONE; HYDROXYLATION; OLIGOMERIZATION; PLANTS (BOTANY); POLYPEPTIDES;

COLLAGEN;

2 OXOGLUTARIC ACID; HYDROXYLYSINE; PROCOLLAGEN LYSINE 2 OXOGLUTARATE 5 DIOXYGENASE; PROCOLLAGEN LYSINE 2 OXOGLUTARATE 5 DIOXYGENASE 2; RECOMBINANT PROCOLLAGEN 1 DOMAIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BONE STRUCTURE; BRUCK SYNDROME 2; CATALYSIS; CONTROLLED STUDY; CROSS LINKING; ENZYME ACTIVITY; ENZYME PURIFICATION; GENE MUTATION; INSECT; MISSENSE MUTATION; MUTANT; NONHUMAN; OLIGOMERIZATION; OSTEOGENESIS IMPERFECTA; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; WILD TYPE;

ANIMALS; CELL LINE; CONNECTIVE TISSUE DISEASES; HUMANS; KINETICS; MUTATION, MISSENSE; PROCOLLAGEN-LYSINE, 2-OXOGLUTARATE 5-DIOXYGENASE; PROTEIN FOLDING; RECOMBINANT PROTEINS; SPODOPTERA;

HEXAPODA;

EID: 71449127603     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.021238     Document Type: Article

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