Driving gradual endogenous c-myc overexpression by flow-sorting: Intracellular signaling and tumor cell phenotype correlate with oncogene expression

Archives of Toxicology

Volumn 83, Issue 12, 2009, Pages 1061-1074

  Knudsen, Kasper Jermiin ^a,b   Nelander Holm, Gitte Mai ^b   Krabbe, Jonas S ^b   Listov Saabye, Nicolai ^b   Kiehr, Benedicte ^b   Dufva, Martin ^a   Svendsen, Jette E ^b   Oleksiewicz, Martin B ^c  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c INTERCELL AG   (Austria)

Author keywords

C myc; Fluorescence activated cell sorting; Green fluorescent protein; Insulin mitogenicity; Molecular toxicology; Preclinical carcinogenicity safety assessment

Indexed keywords

HISTONE H3; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN S6; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BREAST ADENOCARCINOMA; CELL ADHESION; CELL CYCLE; CELL POPULATION; CELL SELECTION; CELL SIZE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; IN VITRO STUDY; MITOGENESIS; NONHUMAN; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TUMOR CELL;

ADENOCARCINOMA; ANIMALS; CELL ADHESION; CELL LINE, TUMOR; CELL SEPARATION; FEMALE; FLOW CYTOMETRY; HISTONES; INSULIN; MAMMARY NEOPLASMS, ANIMAL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHENOTYPE; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MYC; RATS; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION;

RATTUS;

EID: 71449092266     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-009-0463-6     Document Type: Article

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