Controversies on humoral immune markers of insulin-dependent diabetes mellitus

Journal of Pediatric Endocrinology and Metabolism

Volumn 11, Issue SUPPL. 2, 1998, Pages 307-317

  Falorni, Alberto ^a   Kassi, Georgia ^a   Murdolo, Giuseppe ^a   Calcinaro, Filippo ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Autoantibodies; Autoantigens; Gl utamic acid decarboxylase; Insulin; Prediction; Prevention; Protein tyrosine phosphatase; Radioimmunoassay

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; INSULIN;

ANTIBODY DETECTION; AUTOIMMUNITY; CONFERENCE PAPER; DIAGNOSTIC ACCURACY; HUMAN; HUMAN CELL; HUMAN TISSUE; HUMORAL IMMUNITY; IMMUNOFLUORESCENCE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; PREDICTION;

AUTOANTIBODIES; BIOLOGICAL MARKERS; DIABETES MELLITUS, TYPE 1; HUMANS; ISLETS OF LANGERHANS; SENSITIVITY AND SPECIFICITY;

EID: 7144242336     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (77)

1. Lernmark Å, Falorni A. Immunology of insulin-dependent diabetes mellitus. In: Pickup J, Williams G, eds. Textbook of Diabetes. Blackwell Science, 1997; 15.1-15.23.
2. Falorni A, Lernmark Å. Humoral autoimmunity. In: LeRoith D, Taylor SI, eds. Diabetes Mellitus. Philadelphia: Lippincott-Raven Publ, 1996; 298-307.
3. Bottazzo GF, Florin-Christensen A, Doniach D. Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 1974; II: 1279-1283.
4. McCuish AC, Irvine JW, Barnes EW, Duncan LJP. Antibodies to pancreatic islet cells in insulin-dependent diabetes with coexistent autoimmune disease. Lancet 1974; II: 1529-1531.
5. Lendrum R, Walker G, Gamble DR. Islet-cell antibodies in juvenile diabetes mellitus of recent onset. Lancet 1975; I: 880-883.
6. Bottazzo GF, Gleichmann H. Workshop report. Immunology and diabetes workshops: report of the first international workshop on the standardisation of cytoplasmic islet cell antibodies. Diabetologia 1986; 29: 125-126.
7. Bonifacio E, Lernmark Å, Dawkins RL. Serum exchange and use of dilutions have improved precision of measurement of islet cell antibodies. J Immunol Methods 1988; 106: 83-88.
8. Boitard C, Bonifacio E, Bottazzo GF, Gleichmann H, Molenaar J. Immunology and diabetes workshop: report on the third international (Stage 3) workshop on the standardisation of cytoplasmic islet cell antibodies. Diabetologia 1988; 31: 451-452.
9. Landin-Olsson M. Precision of the islet cell antibody assay depends on the pancreas. J Clin Lab Anal 1990; 4: 289-294.
10. Atkinson MA, Maclaren NK. Islet cell autoantigens in insulin-dependent diabetes. J Clin Invest 1993; 92; 1608-1616.
11. Sanjeevi CB, Falorni A, Robertson J, Lernmark Å. Glutamic acid decarboxylase (GAD) in insulin-dependent diabetes mellitus. Diab Nutr Metab 1996; 9: 167-182.
12. Bonifacio E, Christie MR. Tyrosin phosphatase-like proteins as autoantigens in insulin-dependent diabetes mellitus: The targets of 37/40k-antibodies. Diab Nutr Metab 1996; 9: 183-187.
13. Kuglin B, Kolb H, Greenbaum C, Maclaren NK, Lernmark Å, Palmer JP. The fourth international workshop on the standardisation of insulin autoantibody measurement. Diabetologia 1990; 33: 638-639.
14. Schmidli RS, Colman PG, Bonifacio E, Bottazzo GF, Harrison LC. High level of concordance between assays for glutamic acid decarboxylase antibodies. The First International Glutamic Acid Decarboxylase Antibody Workshop. Diabetes 1994; 43: 1005-1009.
15. Schmidli RS, Colman PG, Bonifacio E and participating laboratories. Disease sensitivity and specificity of 52 assays for glutamic acid decarboxylase antibodies: The Second International GADAb Workshop. Diabetes 1995; 44: 636-640.
16. Marner B, Agner T, Binder C, Lernmark Å, Nerup J, Mandrup-Poulsen T. Increased reduction in fasting C-peptide is associated with islet cell antibodies in type 1 (insulin-dependent) diabetic patients. Diabetologia 1985; 28: 875-880.
17. Landin-Olsson M, Palmer JP, Lernmark Å, Blom L, Sundkvist G, Nyström L, Dahlquist G. Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed and matched control children. Diabetologia 1992; 35: 1068-1073.
18. Vandewalle CL, Falorni A, Svanholm S, Lernmark Å, Pipeleers DG, Gorus FK, Belgian Diabetes Registry. High diagnostic sensitivity of glutamate decarboxylase autoantibodies in insulin-dependent diabetes mellitus with clinical onset between age 20 and 40 years. J Clin Endocrinol Metab 1995; 80: 846-851.
19. Wallensteen M, Dahlquist G, Persson B, Landin-Olsson M, Lernmark Å, Sundkvist G, Thalme B. Factors influencing the magnitude, duration, and rate of fall of B-cell function in type 1 (insulin-dependent) diabetes children followed for two years from their clinical diagnosis. Diabetologia 1988; 31: 664-669.
20. Schiffrin A, Ciampi A, Hendricks L, Rozen R, Weitzer G. Evidence for different clinical subtypes of type 1 diabetes mellitus: a prospective study. Diabetes Res Clin Pract 1994; 23: 95-102.
21. Palmer JP, Asplin CM, Clemons P, Lyen K, Tatpati O, Raghu PK, Paguette TL. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 1983; 222: 1337-1339.
22. Vandewalle CL, Decraene T, Schuit FC, De-Leeuw IH, Pipeleers DG, Gorus FK. Insulin autoantibodies and high titre islet cell antibodies are preferentially associated with the HLA-DQA1*0301-DQB1*0302 haplotype at clinicai onset of type 1 (insulin-dependent) diabetes mellitus before age 10, but not at onset between age 10 and 40 years. Diabetologia 1993; 36: 1155-1162.
23. Vardi P, Ziegler AG, Matthews JH, Diub S, Keller RJ, Ricker AT, Wolfsdorf JI, Herskowitz RD, Rabizadeh A, Eisenbarth GS. Concentration of insulin autoantibodies at onset of type I diabetes: inverse log-linear correlation with age. Diabetes Care 1988; 9: 736-739.
24. Pugliese A, Bugawan R, Moromisato R, Awdeh ZL, Alper CA, Jackson RA, Erlich HA, Eisenbarth GS. Two subsets of HLA-DQA1 alleles mark phenotypic variation in levels of insulin autoantibodies in first-degree relatives at risk for insulin-dependent diabetes. J Clin Invest 1994; 93: 2447-2452.
25. Gorus FK, Vandewalle CL, Dorchy H, Van Crombrugge P, Schuit FC, Pipeleers DG, Belgian Diabetes Registry. Influence of age on the associations among insulin autoantibodies, islet cell antibodies, and HLA DQA1*0301-DQB1*0302 and siblings of patients with type 1 (insulin-dependent) diabetes mellitus. J Clin Endocrinol Metab 1994; 78: 1172-1178.
26. Hagopian WA, Sanjeevi CB, Kockum I, Landin-Olsson M, Karlsen AE, Sundkvist G, Dahlquist G, Palmer J, Lernmark A. Glutamate decarboxylase-, insulin- and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J Clin Invest 1995; 95: 1505-1511.
27. Knip M, Ilonen J, Mustonen A, Åkerblom HK. Evidence of an accelerated beta-cell destruction in HLA-Dw3/Dw4 heterozygous children with type 1 (insulin-dependent) diabetes. Diabetologia 1986; 29: 347-351.
28. Baekkeskov S, Nielsen JH, Marner B, Bilde T, Ludvigsson J, Lernmark Å. Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature 1982; 298: 167-169.
29. Baekkeskov S, Aanstoot HL, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter-Olesen H, DeCamilli P. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990; 347: 151-156.
30. Karlsen AE, Hagopian WA, Grubin CE, Dube S, Disteche CM, Adler DA, Barmeier H, Mathewes S, Grant FJ, Foster D, Lernmark Å. Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. Proc Natl Acad Sci USA 1991; 88: 8337-8341.
31. Bu D-F, Erlander MG, Hitz BC, Tillakaratne NJK, Kaufman DL, Wagner-McPherson CB, Evans GA, Tobin AJ. Two human glutamate decarboxylase, 65-kDa and 67-kDa GAD, are each encoded by a single gene. Proc Natl Acad Sci USA 1992; 89: 2115-2119.
32. Petersen JS, Russel S, Marshall MO, Kofod H, Buschard K, Cambon N, Kerlsen AE, Boel E, Hagopian WA, Hejnaes KR, Lernmark Å, Michelsen BK. Differential expression of glutamic acid decarboxylase in rat and human islets. Diabetologia 1993; 42: 484-495.
33. Karlsen AE, Hagopian WA, Petersen JS, Boel E, Dyrberg T, Grubin CE, Michelsen BK, Madsen OD, Lernmark Å. Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64,000-Mr autoantibodies. Diabetes 1992; 41: 1355-1359.
34. Velloso LA, Kämpe O, Hallberg A, Christmanson L, Betsholtz C, Karlsson FA. Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type I diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression. J Clin Invest 1993; 91: 2084-2090.
35. Grubin CE, Daniels T, Toivola B, Landin-Olsson M, Hagopian WA, Li L, Karlsen AE, Boel E, Michelsen BK, Lernmark Å. A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia 1994; 37: 344-350.
36. Petersen JS, Hejnaes KR, Moody A, Karlsen AE, Marshall MO, Hoier-Madsen M, Boel E, Michelsen BK, Dyrberg T. Detection of GAD65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay. Diabetes 1994; 43: 459-467.
37. 3H recombinant human ligands. J Immunol Methods 1995; 186: 89-99.
38. Falomi A, Ackefors M, Carlberg C, Daniels T, Persson B, Robertson J, Lemmark Å. Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM. Diabetologia 1996; 39: 1091-1098.
39. Falorni A, Grubin CE, Takei I, Shimada A, Kasuga A, Maruyama T, Ozawa Y, Kasatani T, Saruta T, Li L, Lernmark Å. Radioimmunoassay detects the frequent occurrence of autoantibodies to the Mr 65,000 isoform of recombinant human glutamic acid decarboxylase in Japanese type 1 (insulin-dependent) diabetes. Autoimmunity 1994; 19: 113-125.
40. Sanjeevi CB, Falorni A, Kockum I, Hagopian W, Lernmark Å. HLA and glutamic acid decarboxylase in human insulin-dependent diabetes mellitus. Diabetic Med 1996; 13: 209-217.
41. Serjeantson SW, Court J, Mackay IR, Matheson B, Rowley MJ, Tuomi T, Wilson JD, Zimmet P. HLA-DQ genotypes are associated with autoimmunity to glutamic acid decarboxylase in insulin-dependent diabetes mellitus patients. Hum Immunol 1993; 38: 97-104.
42. Vandewalle CL, Falorni A, Lernmark Å, Goubert P, Dorchy H, Coucke W, Semakula C, Van Der Auwera B, Kaufman L, Schuit FC, Pipeleers DG, Gorus FK. Associations of GAD65- and IA2-autoantibodies with genetic markers in new-onset IDDM patients and their siblings. The Belgian Diabetes Registry. Diabetes Care 1997; 20: 1547-1552.
43. Kasuga A, Falorni A, Maruyama T, Ozawa Y, Grubin CE, Matsubara K, Takei I, Saruta T, Scheynius A, Lernmark Å. HLA class II is associated with the frequency of glutamic acid decarboxylase Mr 65,000 autoantibodies in Japanese patients with insulin-dependent diabetes mellitus. Acta Diabetol 1996; 33: 108-113.
44. Serjeantson SW, Kohonen-Corish MRJ, Rowley MJ, Mackay IR, Knowles W, Zimmet P. Antibodies to glutamic acid decarboxylase are associated with HLA-DR genotypes in both Australians and Asians with type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1992; 35: 996-1001.
45. Kawasaki E, Takino H, Yano M, Uotani S, Matsumoto K, Takao Y, Yamaguchi Y, Akazawa S, Nagataki S. Autoantibodies to glutamic acid decarboxylase in patients with IDDM and autoimmune thyroid disease. Diabetes 1994; 43: 80-86.
46. Sanjeevi CB, Sthauvere A, Ramachandran A, Snehalatha C, Falorni A. Prevalence of GAD65 autoantibodies in South Indian patients with insulin-dependent diabetes mellitus, and in their parents. Diabetes Nutr Metab 1997; 10: 60-64.
47. Tuomi T, Zimmet P, Rowley MJ, Min HK, Vichayanrat A, Lee HK, Rhee BD, Vannasaeng S, Humphrey AR, Mackay IR. Differing frequency of autoantibodies to glutamic acid decarboxylase among Koreans, Thais and Australians with diabetes mellitus. Clin Exp Immunol 1995; 74: 202-206.
48. Zimmet PZ, Rowley MJ, Mackay IR, Knowles WJ, Chen Q-Y, Chapman LH, Serjeantson SW. The ethnic distribution of antibodies to glutamic acid decarboxylase: Presence and levels in insulin-dependent diabetes mellitus in Europid and Asian subjects. Lancet 1993; 340: 1-7.
49. Groop LC, Bottazzo GF, Doniach D. Islet cell antibodies identify latent type 1 diabetes in patients aged 35-75 years at diagnosis. Diabetes 1986; 35: 237-241.
50. Kobayashi T, Tamemoto K, Nakanishi K, Kato N, Okubo M, Kajio H, Sugimoto T, Murase T, Kosaka K. Immunogenetic and clinical characterization of slowly progressive IDDM. Diabetes Care 1993; 16: 780-788.
51. Kasuga A, Maruyama T, Ozawa Y, Takei I, Falorni A, Lernmark Å, Saruta T. Antibodies to the Mr 65,000 isoform of glutamic acid decarboxylase are detected in non-insulin-dependent diabetes in Japanese. J Autoimmun 1996; 9: 105-111.
52. Hagopian WA, Karlsen AE, Gottsaeter A, Landin-Olsson ML, Grubin CE, Sundkvist G, Petersen JS, Boel E, Dyrberg T, Lernmark Å. Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type. J Clin Invest 1993; 91: 368-374.
53. Tuomi T, Groop LC, Zimmet P, Rowley MJ, Knowles W, Mackay IR. Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes 1993; 42: 359-362.
54. Christie MR, Vohra G, Champagne P, Daneman D, Delovitch TL. Distinct antibody specificities to a 64-kD islet cell antigen in type 1 diabetes as revealed by trypsin treatment. J Exp Med 1990; 172: 789-794.
55. Christie MR, Hollands JA, Brown TJ, Michelsen BK, Delovitch TL. Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. J Clin Invest 1993; 92: 240-248.
56. Payton MA, Hawkes CJ, Christie MR. Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J Clin Invest 1995; 96: 1506-1511.
57. Bonifacio E, Lampasona V, Genovese S, Ferrari M, Bosi E. Identification of protein tyrosine phosphatase-like IA2 (Islet Cell Antigen 512) as the insulin-dependent diabetes-related 37/40K autoantigen and a target of islet-cell antibodies. J Immunol 1995; 155: 5419-5426.
58. Lu J, Li Q, Xie H, Chen Z, Borovitskaya AE, Maclaren NK, Notkins AL, Lan MS. Identification of a second transmembrane protein tyrosine phosphatase, IA-2, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment. Proc Natl Acad Sci USA 1996; 93: 2307-2312.
59. Genovese S, Bonfanti R, Bazzigaluppi E, Lampasona V, Benazzi E, Bosi E, Chiumello G, Bonifacio E. Association of IA-2 autoantibodies with HLA DR4 phenotypes in IDDM. Diabetologia 1996; 39: 1223-1226.
60. Gorus FK, Goubert P, Semakula C, Vandewalle CL, De Schepper J, Scheen A, Christie MR, Pipeleers DG, Belgian Diabetes Registry. IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia 1997; 40: 95-99.
61. Landin-Olsson M, Karlsson A, Dahlquist G, Blom L, Lernmark Å, Sundkvist G. Islet cell and other organspecific autoantibodies in all children developing type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched controls. Diabetologia 1989; 32: 387-395.
62. Bosi E, Becker F, Bonifacio E, Wagner R, Collins P, Gale EAM, Bottazzo GF. Progression to type 1 diabetes in autoimmune endocrine patients with islet cell antibodies. Diabetes 1991; 40: 977-984.
63. Wagner R, Genovese S, Bosi E, Becker F, Bingley PJ, Bonifacio E, Miles KA, Christie MR, Bottazzo GF, Gale EA. Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with auto-immune polyendocrine disease. Diabetologia 1994; 37: 365-371.
64. Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P. Autoantibodies to GABA-ergic neurons and pancreatic beta cells in Stiff-Man syndrome. N Engl J Med 1990; 322: 1555-1560.
65. Hallengren B, Falorni A, Landin-Olsson M, Lernmark Å, Papadopoulos KI, Sundkvist G. Islet cell and glutamic acid decarboxylase antibodies in hyperthyroid patients at diagnosis and following treatment. J Intern Med 1996; 239: 63-68.
66. Tuomi T, Björses P, Falorni A, Partanen J, Perheentupa J, Lernmark Å, Miettinen A. Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with APS 1 (autoimmune polyendocrine syndrome type 1). J Clin Endocrinol Metab 1996; 81: 1488-1494.
67. Butler MH, Solimena M, Dirkx R, Hayday A, De Camilli P. Identification of a dominant epitope of glutamic acid decarboxylase (GAD65) recognized by autoantibodies in stiff-man syndrome. J Exp Med 1993; 178: 2097-2106.
68. Björk E, Velloso LA, Kämpe O, Karlsson FA. GAD-autoantibodies in insulin-dependent diabetes mellitus, stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes. Diabetes 1994; 43: 161-165.
69. Richter W, Shi Y, Baekkeskov S. Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase. Proc Natl Acad Sci USA 1993; 90: 2832-2836.
70. Daw K, Powers A. Two distinct glutamic acid decarboxylase autoantibody specificities in IDDM target different epitopes. Diabetes 1995; 44: 216-220.
71. Petersen J, Dyrberg T, Karlsen A, Mölvig J, Michelsen B, Nerup J, Mandrup-Poulsen T. Glutamic acid decarboxylase (GAD65) autoantibodies in prediction of beta-cell function and remission in recent-onset IDDM after cyclosporin treatment. Diabetes 1994; 43: 1291-1296.
72. Peig M, Gomis R, Ercilla G, Casamitjana R, Bottazzo GF, Pujol-Borrell R. Correlation between residual beta-cell function and islet cell antibodies in newly diagnosed type 1 diabetes. Diabetes 1989; 38: 1396-1401.
73. Örtqvist E, Falorni A, Scheynius A, Persson B, Lernmark Å. Age controls gender-dependent islet autoreactivity and predicts the clinical course in childhood IDDM. Acta Paediatr 1997; 86: 1166-1171.
74. Ziegler AJ, Ziegler R, Vardi P, Jackson RA, Soeldner JS, Eisenbarth GS. Life-table analysis of progression to diabetes of anti-insulin autoantibody positive relatives of individuals with type I diabetes. Diabetes 1989; 38: 1320-1325.
75. Bingley P, Bonifacio E, Gale EAM. Can we really predict IDDM? Diabetes 1993; 42: 213-220.
76. Bingley PJ, Christie MR, Bonifacio E, Bonfanti R, Shattock M, Fonte MT, Bottazzo GF, Gale EAM. Combined analysis of IDDM-related autoantibodies improves prediction of IDDM in islet cell antibody positive relatives. Diabetes 1994; 43: 1304-1310.
77. Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, Chase HP, Eisenbarth GS. Prediction of type I diabetes in first-degree relatives using a combination of insulin, glutamic acid decarboxylase and ICA512 autoantibodies. Diabetes 1996; 45: 926-933.