HLA class II is associated with the frequency of glutamic acid decarboxylase M(r) 65,000 autoantibodies in Japanese patients with insulin dependent diabetes mellitus

Acta Diabetologica

Volumn 33, Issue 2, 1996, Pages 108-113

  Kasuga, A ^a,b   Falorni, A ^a   Maruyama, T ^c   Ozawa, Y ^b   Grubin, C E ^d   Matsubara, K ^e   Takei, I ^b   Saruta, T ^b   Scheynius, A ^a   Lernmark, A ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KEIO UNIVERSITY   (Japan)

^c Social Insurance Saitama Chuo Hosp   (Japan)

^d UNIVERSITY OF WASHINGTON   (United States)

^e Chugai Pharmaceutical   (Japan)

Author keywords

Autoantigen; Autoimmunity; Human leukocyte antigen; Insulin dependent diabetes mellitus

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; C PEPTIDE; GLUTAMATE DECARBOXYLASE; HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN; HLA DR ANTIGEN; PANCREAS ISLET CELL ANTIBODY;

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOIMMUNITY; CHILD; CONTROLLED STUDY; DISEASE DURATION; ETIOLOGY; GENE FREQUENCY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; JAPAN; MAJOR CLINICAL STUDY; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 9444231788     PISSN: 09405429     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00569419     Document Type: Article

References (28)

1. Rossini AA, Greiner DL, Friedman HP, Mordes JP, Immunopathogenesis of diabetes mellitus. Diaheles Rev 1:43-75, 1993
2. Colman PG, Nayak RC, Campbell IL, Eisenbarth GS, Binding of cytoplasmic islet cell antibodies is blocked by human pancreatic glycolipid extracts. Diabetes 37-645-652, 1988
3. Palmer JP, Predicting IDDM: use of humoral immune markers. Diabetes Rev 1:104-115, 1993
4. Baekkeskoy S, Nielsen JH, Marner B, Bilde T, Ludvigsson J, Lernmark Å, Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature 298:167-169, 1982
5. Baekkeskov S, Aanstoot HJ, Cristgau S, Reeiz A, Solimena M, Cascalho M, Folli F, Richter-Olesen H, De Camilli P, Identification of the 64 K autoantigen in insulin-dependent diabetes as the GABA-synthesizmg enzyme glutamic acid decarboxylase. Nature 347:151-156, 1991
6. Karlsen AE, Hagopian WA, Grubin CE, Dube S, Disteche CM, Adler DA, Barmeier H, Mathewes S, Grant FJ, Foster D, Lernmark Å, Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. Proc Natl Acad Sci USA 88:8337-8341, 1991
7. Michelsen BK, Petersen JS, Boel E, Møldrup A, Dyrberg T, Madsen OD, Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 88:8754-8758, 1991
8. Bu DF, Erlander MG, Hitz BC, Tillakaratne NJK, Kaufman DL, Wagner-McPherson GB, Evans MG, Tobin AJ, Two human glutamate decarboxylase, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene. Proc Natl Acad Sci USA 89:2115- 2119, 1992
9. Petersen JS, Russel S, Marshall MO, Kofod H, Buschard K, Cambon N, Karlsen AE, Boel E, Hagopian WA, Hejnaes KR, Moody A, Dyrberg T, Lernmark Å, Madsen OD, Michelsen B, Differential expression of glutamic acid decarboxylase in rat and human islets. Diabetes 42:484-495, 1993
10. Hagopian WA, Michelsen B, Karlsen AE, Larsen F, Moody A, Grubin CE, Rowe R, Petersen JS, McEvoy R, Lernmark Å, Auto- antibody in insulin-dependent diabetes primarily recognize the M, 65,000 rather than the M, 67,000 isoform of glutamic acid decarboxylase. Diabetes 42:631-636, 1993
11. Velloso LA, Kampe O, Hallberg A, Chirsrmanson I., Betsholtz C, Karlsson FA, Demonstration of GAD65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression. J Clin Invest 91:2084-2090, 1993
12. Seissler J, Amann J, Mauch L, Haubruck H, Wolfahrt S, Bieg S, Richter W, Holl R, Heinze E, Northemann W, Scherbaum WA, Prevalence of autoantibodies to the 65- and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest 92:1394-1399, 1993
13. T 65,000 isoform of glutamate decarboxylase in Japanese insulin-dependent diabetes. Autoimmunity 19:113-125, 1994
14. Kobayashi T, Tamemoto K, Nakanishi K, Kato N, Okubo M, Kajio H, Sugimoto T, Murase T, Kosaka K, Immunogenetic and clinical characterization of slowly progressive IDDM. Diabetes Care 16:780-788, 1993
15. Schmidli RS, Colman PG, Bonifacio E, Bottazzo GF, Harrison LC, participating laboratories, High level of concordance between assays for glutamic acid decarboxylase antibodies: the first International Glutamic Acid Decarboxylase Antibody Workshop. Diabetes 43:1005-1009, 1994
16. Schmidli RS, Colman PG, Bonifacio E, participating laboratories, Disease sensitivity and specificity of 52 assays for glutamic acid decarboxylase antibodies. The second International GADAb Workshop. Diabetes 44:636-640, 1995
17. Hamaguchi K, Kimura A, Ping Dong R, Noda N, Okeda T, Chikuba N, Nunoi K, Fujishima M, Nagataki S, Takaki R, Sasazuki T, Specific combinations of HLA-DRB and -DQB alleles confer susceptibility while the DQB gene determines resistance to insulin-dependent diabetes mellitus in Japanese. In: Tsuji K, Aizawa M, Sasazuki T (eds) Disease and reproduction studies. HLA 1991: Proceedings of the 11th International Histocompatibility Workshop and Conference. Oxford Science Publications, Oxford, pp488-492, 1992
18. Maruyama T, Shimada A, Kasuga A, Kasatani T, Ozawa Y, Ishii M, Takei I, Suzuki Y, Kobayashi A, Takeda S, Matsubara K, Saruta T, Analysis of MHC class II antigens in Japanese IDDM by novel HLA-typing method, hybridization protection assay. Diabetes Res Clin Pract 23:77-84, 1994
19. Thomson G, Robinson WP, Kuhner MK, Joe S, MacDonald MJ, Gottschall JL, Barbosa J, Rich S, Bertrams J, Baur MP, Partanen J, Tait BD, Schober E, Mayr WR, Ludvigsson J, Lindbolm B, Faird NR, Thompson C, Deschamps I, Modes of inheritance and risk estimates for a joint study of Caucasians with insulin dependent diabetes mellitus. Am J Hum Genet 43:799-816, 1988
20. Todd JA, Bell JI, McDevitt HO, HLA-DQB gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329:599-604, 1987
21. Serjeantson SW, Kohonen-Corish MRJ, Rowley MJ, Mackay IR, Knowles W, Zimmet P, Antibodies to glutamic acid decarboxylase are associated with HLA-DR genotypes in both Australians and Asians with type 1 (insulin-dependent) diabetes mellitus. Diabetologia 35:996-1001, 1992
22. National Diabetes Data Group, Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039-1057, 1979
23. Grubin CE, Daniels T, Toivola B, Landin-Olsson M, Hagopian WA, Li L, Karlsen AE, Boel E, Michelsen B, Lernmark Å, A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase anti- bodies in childhood type 1 diabetes. Diabetologia 37:344-350, 1994
24. Kasuga A, Maruyama T, Ozawa Y, Takei I, Falorni A, Lernmark Å, Saruta T, Antibody to the M 65,000 isoform of glutamic acid decarboxylase are detected in non-insulin-dependent diabetes in Japanese. J Autoimmun 9:105-111, 1996
25. Landin-Olsson M, Nilsson KO, Lernmark Å, Sundkvist G, Islet cell antibodies and fasting C-peptide predict insulin requirement at diagnosis of diabetes mellitus. Diabetologia 33:534-535, 1991
26. Bonifacio E, Lernmark Å, Dawkins RL, Serum exchange and use of dilutions have improved precision of measurement of islet cell antibodies. J Immunol Methods 106:83-88, 1988
27. Kawasaki E, Takino H, Yano M, Uotani S, Matsumoto K, Takao Y, Yamaguchi Y, Akazawa S, Nagataki S, Autoantibodies to glutamatic acid decarboxylase in patients with IDDM and autoimmune thyroid disease. Diabetes 43:80-86, 1994
28. Gorus FK, Vandewalle CL, Dorchy H, Crombrugge PV, Schuit FC, Pipeleers DG, The Belgian Diabetes Registry, Influence of age on the association among insulin autoantibodies, islet cell antibodies, and HLA DQA1*0301-DQB1*0302 in siblings of patients with type 1 (insulin-dependent) diabetes mellitus. J Clin Endocrinol Metab 78:1172-1178, 1994