Age governs gender-dependent islet cell autoreactivity and predicts the clinical course in childhood IDDM

Acta Paediatrica, International Journal of Paediatrics

Volumn 86, Issue 11, 1997, Pages 1166-1171

  Ortqvist E ^a,c   Falorni, A ^a   Scheynius, A ^a   Persson, B ^a   Lernmark, A ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF WASHINGTON   (United States)

^c ST GÖRAN S HOSPITAL   (Sweden)

Author keywords

Autoantibodies; Childhood IDDM; Clinical remission; GAD65Ab; ICA

Indexed keywords

AUTOANTIBODY;

ADOLESCENT; AGE; ANTIBODY RESPONSE; ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; INSULIN RESPONSE; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MALE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PUBERTY; REMISSION; SEX DIFFERENCE; TREATMENT OUTCOME;

EID: 0030716341     PISSN: 08035253     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1651-2227.1997.tb14837.x     Document Type: Article

References (30)

1. Ludvigsson J, Heding LG. C-peptide in children with juvenile diabetes. Diabetologia 1976; 12: 627-30
2. Knig M, Säkkinen A, Huttunen N-P, Käär M-L, Länkelä S, Mustonen A, Åkerblom HK. Postinitial remission in diabetic children - an analysis of 178 cases. Acta Paediatr Scand 1982; 71: 901-8
3. Madsbad S. Prevalence of residual β cell function and its metabolic consequences in Type 1 (insulin-dependent) diabetes. Diabetologia 1983; 24: 141-7
4. Mustonen A, Knip M, Huttunen N-P, Puukka R, Käär M-L, Åkerblom HK. Evidence of delayed B-cell destruction in Type 1 (insulin-dependent) diabetic patients with persisting complement-fixing cytoplasmatic islet cell antibodies. Diabetologia 1984; 27: 421-6
5. Knip M, Ilonen J, Mustonen A, Åkerblom HK. Evidence of accelerated B-cell destruction in HLA-Dw3/Dw4 heterogzygous children with Type 1 (insulin-dependent) diabetes. Diabetologia 1986; 29: 347-51
6. Marner B, Sagner T, Binder C, Lernmark A, Mandrup-Poulsen T, Walldorff S. Increased reduction in fasting C-peptide is associated with islet cell antibodies in type 1 (insulin-dependent) diabetic patients. Diabetologia 1985; 28: 875-80
7. Sochett EB, Daneman D, Clarson C, Erlich RM. Factors affecting and patterns of residual insulin secretion during the first year of Type 1 (insulin-dependent) diabetes mellitus in children. Diabetologia 1987; 30: 453-9
8. Wallensteen M, Dahlqvist G, Persson B, Landin-Olsson M, Lernmark A, Sundqvist G, et al. Factors influencing the magnitude, duration and rate of fall of B-cell function in type I (insulin-dependent) diabetic children followed for two years from their clinical diagnosis. Diabetologia 1988; 31: 664-9
9. Petersen J, Dyrberg T, Karlsen A, Mölvig J, Michelsen B, Nerup J, et al. Glutamic acid decarboxylase (GAD65) autoantibodies in prediction of beta-cell function and remission in recent-onset IDDM after cyclosporin treatment. Diabetes 1994; 43: 1291-6
10. Gorsuch AN, Spencer KM, Lister J, McNally JM, Dean BM, Bottazzo GF, et al. Evidence for a long prediabetic period in type 1 (insulin-dependent) diabetes mellitus. Lancet 1981; 19 : 1363-5
11. 65 combined with islet cell cytoplasmatic antibodies for predicting IDDM in a childhood population. Diabetologia 1994; 37: 917-24
12. Baekkeskov S, Aanstoot H-K, Christgau S, Reetz A, Solimena M, Cascalho M, et al. Identification of the 64K autoantigen in insulin dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990; 347: 151-6
13. Karlsen AE, Hagopian WA, Petersen JS, et al. Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64,000-M(r) autoantibodies. Diabetes 1992; 41: 1355-9
14. Karlsen AE, Hagopian WA, Grubin CE, et al. Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. Proc Natl Acad Sci USA 1991; 88: 8337-341
15. Grubin CE, Daniels T, Toivola B, Landin-Olsson M, Hagopian WA, Li L, et al. A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia 1994; 37: 344-50
16. Kämpe O, Andesson A, Björk E, Hallberg A, Karlsson FA. High glucose stimulation of 64, 000-Mr islet cell autoantigen expression. Diabetes 1989; 38: 1326-8
17. Björk E, Kämpe O, Karlsson FA, Pipeleers DG, Andersson A. Hellerström C, et al. Glucose regulation of the autoantigen GAD65in human pancreatic islets. J Clin Endocrin Metabol 1992; 75: 1574-6
18. Baekkeskov S, Landin M, Kristensen JK, Srikanta S, Bruining J, Mandrup-Poulsen T, et al. Antibodies to a 64, 000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes. J Clin Invest 1987; 79: 926-34
19. Christie M, Landin-Olsson M, Sundqvist G, Lernmark A, Baekkeskov S. Antibodies to a Mr-64000 islet cell protein in Swedich children with newly diagnosed type 1 (insulin-dependent) diabetes. Diabetologia 1988; 31: 597-602
20. Vandewalle CL, Falorni A, Svanholm S, Lernmark Å, Pipeleers DG, Gorus FK. High diagnostic sensitivity of glutamate decarboxylase autoantibodies in insulin-dependent diabetes mellitus with clinical onset between age 20 and 40 years. J Clin Endocrinol Metab 1995 ; 80: 846-51
21. 3H recombinant human ligands. J Immun Meth 1995; 186: 89-99
22. Schmidli RS, Colman PG, Bonifacio E, Bottazzo GF, Harrison LC. and participating laboratories. High level of concordance between assays for glutamic acid decarboxylase: the First International Glutamic Acid Decarboxylase Antibody Workshop. Diabetes 1994; 43: 1005-9
23. Landin-Olsson M, Nilsson KO, Lernmark Å, Sundqvist G. Islet cell antibodies and fasting C-peptide predict insulin requirement at diagnosis of diabetes mellitus. Diabetologia 1990; 33: 561-8
24. Bonifacio E, Lernmark Å, Dawkins RL, et al. Serum exchange and use of dilutions have improved precision of measurment of islet cell antibodies. J Immun Meth 1988; 106: 83-8
25. Lernmark Å, Molenaar JL, van Beers WAM, Yamaguchi Y, Nagataki S, Ludvigsson J, et al. The fourth International Serum Exchange Workshop to standardize cytoplasmatic islet cell antibodies. Workshop report. Diabetologia 1991; 34: 534-5
26. Heding L. Radioimmunological determination of human C-peptide in serum. Diabetologia 1975; 11: 541-8
27. Makesa K, Parmar B, Machin D. Survival analysis, a practical approach. Wiley & Sons, 1995
28. Statistical principles in experimental design. 2nd Ed. Winer, 1971
29. Kockum I, Lernmark Å, Sanjeevi C, Wassmuth R, Landin-Olsson M, Sundkvist G, et al. The risk for insulin-dependent diabetes mellitus associated with HLA-DR, -DQA1, -DQB1 and islet cell antibodies varies with age as well as season at onset and gender of patients. Dissertation, Karolinska Institute, 1995
30. Arslanian S, Heil B, Becker D, Drash A. Sexual dimorphism in insulin sensitivity in adolescents with insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1991; 72: 920-6