Activity of the novel peptide arminin against multiresistant human pathogens shows the considerable potential of phylogenetically ancient organisms as drug sources

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 12, 2009, Pages 5245-5250

  Augustin, René ^a   Anton Erxleben, Friederike ^a   Jungnickel, Stephanie ^a   Hemmrich, Georg ^a   Spudy, Björn ^a   Podschun, Rainer ^a   Bosch, Thomas C G ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; ANTIINFECTIVE AGENT; C ARMININ 1A FUSION PROTEIN; POLYPEPTIDE ANTIBIOTIC AGENT; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS MEGATERIUM; BACTERIAL CELL WALL; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; CELL DISRUPTION; COELENTERATE; DRUG ACTIVITY; ELECTRON MICROSCOPY; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ERYTHROCYTE MEMBRANE; ESCHERICHIA COLI; IN SITU HYBRIDIZATION; KLEBSIELLA PNEUMONIAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MULTIDRUG RESISTANCE; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN DEGRADATION; SEQUENCE HOMOLOGY; ULTRASTRUCTURE; VANCOMYCIN RESISTANT ENTEROCOCCUS;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; CELL WALL; COMPUTATIONAL BIOLOGY; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ERYTHROCYTES; HEMOLYSIS; HUMANS; IN SITU HYBRIDIZATION; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR SEQUENCE DATA; PEPTIDES; PHYLOGENY; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 71249163432     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00826-09     Document Type: Article

References (29)

1. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
2. Augustin, R., A. Franke, K. Khalturin, R. Kiko, S. Siebert, G. Hemmrich, and T. C. Bosch. 2006. Dickkopf related genes are components of the positional value gradient in Hydra. Dev. Biol. 296:62-70.
3. Augustin, R., S. Siebert, and T. C. Bosch. 2009. Identification of a kazal-type serine protease inhibitor with potent anti-staphylococcal activity as part of Hydra's innate immune system. Dev. Comp. Immunol. 33:830-837.
4. Bendtsen, J. D., H. Nielsen, G. von Heijne, and S. Brunak. 2004. Improved prediction of signal peptides: SignalP 3.0. J. Mol. Biol. 340:783-795.
5. Bosch, T. C., R. Augustin, F. Anton-Erxleben, S. Fraune, G. Hemmrich, H. Zill, P. Rosenstiel, G. Jacobs, S. Schreiber, M. Leippe, M. Stanisak, J. Grotzinger, S. Jung, R. Podschun, J. Bartels, J. Harder, and J. M. Schroder. 2009. Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence. Dev. Comp. Immunol. 33:559-569.
6. Chenna, R., H. Sugawara, T. Koike, R. Lopez, T. J. Gibson, D. G. Higgins, and J. D. Thompson. 2003. Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res. 31:3497-3500. (Pubitemid 37442184)
7. Clark, D. P., S. Durell, W. L. Maloy, and M. Zasloff. 1994. Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin. J. Biol. Chem. 269:10849-10855.
8. Fedders, H., and M. Leippe. 2008. A reverse search for antimicrobial peptides in Ciona intestinalis: identification of a gene family expressed in hemocytes and evaluation of activity. Dev. Comp. Immunol. 32:286-298.
9. Fraune, S., Y. Abe, and T. Bosch. 2009. Disturbing epithelial homeostasis in the metazoan Hydra leads to drastic changes in associated microbiota. Environ. Microbiol. 11:2361-2369.
10. Fraune, S., and T. C. Bosch. 2007. Long-term maintenance of species-specific bacterial microbiota in the basal metazoan Hydra. Proc. Natl. Acad. Sci. USA 104:13146-13151.
11. Harder, J., J. Bartels, E. Christophers, and J. M. Schroder. 2001. Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem. 276:5707-5713.
12. Hemmrich, G., and T. C. Bosch. 2008. Compagen, a comparative genomics platform for early branching metazoan animals, reveals early origins of genes regulating stem-cell differentiation. Bioessays 30:1010-1018.
13. Hemmrich, G., D. J. Miller, and T. C. Bosch. 2007. The evolution of immunity: a low-life perspective. Trends Immunol. 28:449-454.
14. Hughes, D. 2003. Exploiting genomics, genetics and chemistry to combat antibiotic resistance. Nat. Rev. Genet. 4:432-441.
15. Jones, D. E., and C. L. Bevins. 1992. Paneth cells of the human small intestine express an antimicrobial peptide gene. J. Biol. Chem. 267:23216-23225.
16. Jung, S., A. J. Dingley, R. Augustin, F. Anton-Erxleben, M. Stanisak, C. Gelhaus, T. Gutsmann, M. U. Hammer, R. Podschun, A. M. Bonvin, M. Leippe, T. C. Bosch, and J. Grotzinger. 2009. Hydramacin-1, structure and antibacterial activity of a protein from the basal metazoan Hydra. J. Biol. Chem. 284:1896-1905.
17. Khalturin, K., F. Anton-Erxleben, S. Sassmann, J. Wittlieb, G. Hemmrich, and T. C. Bosch. 2008. A novel gene family controls species-specific morphological traits in Hydra. PLoS Biol. 6:e278.
18. Lai, Y., and R. L. Gallo. 2009. AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol. 30:131-141.
19. Leclercq, R. 2009. Epidemiological and resistance issues in multidrug-resistant staphylococci and enterococci. Clin. Microbiol. Infect. 15:224-231.
20. Li, M., B. A. Diep, A. E. Villaruz, K. R. Braughton, X. Jiang, F. R. DeLeo, H. F. Chambers, Y. Lu, and M. Otto. 2009. Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus. Proc. Natl. Acad. Sci. USA 106:5883-5888.
21. Li, S. J., and M. Hochstrasser. 1999. A new protease required for cell-cycle progression in yeast. Nature 398:246-251. (Pubitemid 29142860)
22. Livermore, D. 2004. Can better prescribing turn the tide of resistance? Nat. Rev. Microbiol. 2:73-78.
23. Miller, D. J., G. Hemmrich, E. E. Ball, D. C. Hayward, K. Khalturin, N. Funayama, K. Agata, and T. C. Bosch. 2007. The innate immune repertoire in cnidaria - ancestral complexity and stochastic gene loss. Genome Biol. 8:R59.
24. Payne, D. J., M. N. Gwynn, D. J. Holmes, and D. L. Pompliano. 2007. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 6:29-40.
25. Rosenstiel, P., E. E. R. Philipp, S. Schreiber, and T. C. G. Bosch. 2009. Evolution and function of innate immune receptors-insights from marine invertebrates. J. Innate Immun. 1:291-300.
26. Sahly, H., S. Schubert, J. Harder, P. Rautenberg, U. Ullmann, J. Schroder, and R. Podschun. 2003. Burkholderia is highly resistant to human betadefensin 3. Antimicrob. Agents Chemother. 47:1739-1741.
27. Sass, V., U. Pag, A. Tossi, G. Bierbaum, and H. G. Sahl. 2008. Mode of action of human beta-defensin 3 against Staphylococcus aureus and transcriptional analysis of responses to defensin challenge. Int. J. Med. Microbiol. 298:619-633.
28. Walsh, C. 2003. Where will new antibiotics come from? Nat. Rev. Microbiol. 1:65-70.
29. Zhao, C., L. Liaw, I. H. Lee, and R. I. Lehrer. 1997. cDNA cloning of clavanins: antimicrobial peptides of tunicate hemocytes. FEBS Lett. 410:490-492. (Pubitemid 27304123)