Proliferating cells in HIV and pamidronate-associated collapsing focal segmental glomerulosclerosis are parietal epithelial cells

Kidney International

Volumn 70, Issue 2, 2006, Pages 338-344

  Dijkman, H B P M ^a   Weening, J J ^b   Smeets, B ^a   Verrijp, K C N ^a   Van Kuppevelt, T H ^a   Assmann, K K J M ^a   Steenbergen, E J ^a   Wetzels, J F M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Collapsing lesions and glomerulosclerosis; Epithelial cell proliferation; HIV; Pamidronate; Parietal epithelial cell; Podocyte

Indexed keywords

CELL MARKER; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; HEPARAN SULFATE; KI 67 ANTIGEN; PAMIDRONIC ACID; SYNAPTOPODIN; TRANSCRIPTION FACTOR PAX2; VASCULOTROPIN;

ARTICLE; BIOPSY; CELL PROLIFERATION; EPITHELIUM CELL; EXTRACELLULAR MATRIX; GLOMERULOSCLEROSIS; GLOMERULUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN TISSUE; IMMUNOCHEMISTRY; MICROSCOPY; NEPHRECTOMY; PHENOTYPE; PODOCYTE; PRIORITY JOURNAL;

AIDS-ASSOCIATED NEPHROPATHY; ANTINEOPLASTIC AGENTS; BIOLOGICAL MARKERS; BIOPSY; CELL DIVISION; DIPHOSPHONATES; EPITHELIAL CELLS; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; KIDNEY GLOMERULUS; PODOCYTES;

EID: 33746133167     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5001574     Document Type: Article

References (26)

1. Haas M, Meehan SM, Karrison TG et al. Changing etiologies of unexplained adult nephrotic syndrome: a comparison of renal biopsy findings from 1976-1979 and 1995-1997. Am J Kidney Dis 1997; 30: 621-631.
2. D'Agati V. Pathologic classification of focal segmental glomerulosclerosis. Semin Nephrol 2003; 23: 117-134.
3. Kriz W, Elger M, Nagata M et al. The role of podocytes in the development of glomerular sclerosis. Kidney Int Suppl 1994; 45: S64-S72.
4. Kriz W, Kretzler M, Nagata M et al. A frequent pathway to glomerulosclerosis: deterioration of tuft architecture-podocyte damage-segmental sclerosis. Kidney Blood Press Res 1996; 19: 245-253.
5. Kriz W, Gretz N, Lemley KV. Progression of glomerular diseases: is the podocyte the culprit? Kidney Int 1998; 54: 687-697.
6. Mundel P, Shankland SJ. Podocyte biology and response to injury. J Am Soc Nephrol 2002; 13: 3005-3015.
7. Barisoni L, Kriz W, Mundel P et al. The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol 1999; 10: 51-61.
8. Barisoni L, Mokrzycki M, Sablay L et al. Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies. Kidney Int 2000; 58: 137-143.
9. Bariety J, Nochy D, Mandet C et al. Podocytes undergo phenotypic changes and express macrophagic-associated markers in idiopathic collapsing glomerulopathy. Kidney Int 1998; 53: 918-925.
10. Bariety J, Bruneval P, Hill G et al. Posttransplantation relapse of FSGS is characterized by glomerular epithelial cell transdifferentiation. J Am Soc Nephrol 2001; 12: 261-274.
11. Barisoni L, Kopp JB. Modulation of podocyte phenotype in collapsing glomerulopathies. Microsc Res Tech 2002; 57: 254-262.
12. Nagata M, Horita S, Shu Y et al. Phenotypic characteristics and cyclin-dependent kinase inhibitors repression in hyperplastic epithelial pathology in idiopathic focal segmental glomerulosclerosis. Lab Invest 2000; 80: 869-880.
13. Nagata M, Tomari S, Kanemoto K et al. Podocytes, parietal cells, and glomerular pathology: the role of cell cycle proteins. Pediatr Nephrol 2003; 18: 3-8.
14. Kihara I, Yaoita E, Kawasaki K et al. Origin of hyperplastic epithelial cells in idiopathic collapsing glomerulopathy. Histopathology 1999; 34: 537-547.
15. Smeets B, Te Loeke NA, Dijkman HB et al. The parietal epithelial cell: a key player in the pathogenesis of focal segmental glomerulosclerosis in Thy-1.1 transgenic mice. J Am Soc Nephrol 2004; 15: 928-939.
16. Asano T, Niimura F, Pastan I et al. Permanent genetic tagging of podocytes: fate of injured podocytes in a mouse model of glomerular sclerosis. J Am Soc Nephrol 2005; 16: 2257-2262.
17. Dijkman H, Smeets B, van der Laak J et al. The parietal epithelial cell is crucially involved in human idiopathic focal segmental glomerulosclerosis. Kidney Int 2005; 68: 1562-1572.
18. Ronco P, Ardaillou N, Verroust P et al. Pathophysiology of the podocyte: a target and a major player in glomerulonephritis. Adv Nephrol Necker Hosp 1994; 23: 91-131.
19. He JC, Husain M, Sunamoto M et al. Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. J Clin Invest 2004; 114: 643-651.
20. Husain M, D'Agati VD, He JC et al. HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. AIDS 2005; 19: 1975-1980.
21. Zhong J, Zuo Y, Ma J et al. Expression of HIV-1 genes in podocytes alone can lead to the full spectrum of HIV-1-associated nephropathy. Kidney Int 2005; 68: 1048-1060.
22. Platt JL, LeBien TW, Michael AF. Stages of renal ontogenesis identified by monoclonal antibodies reactive with lymphohemopoietic differentiation antigens. J Exp Med 1983; 157: 155-172.
23. Assmann KJ, Tangelder MM, Lange WP et al. Membranous glomerulonephritis in the mouse. Kidney Int 1983; 24: 303-312.
24. van Kuppevelt TH, Dennissen MA, van Venrooij WJ et al. Generation and application of type-specific anti-heparan sulfate antibodies using phage display technology. Further evidence for heparan sulfate heterogeneity in the kidney. J Biol Chem 1998; 273: 12960-12966.
25. Dennissen MA, Jenniskens GJ, Pieffers M et al. Large, tissue-regulated domain diversity of heparan sulfates demonstrated by phage display antibodies. J Biol Chem 2002; 277: 10982-10986.
26. Leenders WP, Kusters B, Verrijp K et al. Antiangiogenic therapy of cerebral melanoma metastases results in sustained tumor progression via vessel co-option. Clin Cancer Res 2004; 10: 6222-6230.