In vivo quantification of intraarticular cytokines in knees during natural and surgically induced cartilage repair

Cytotherapy

Volumn 11, Issue 8, 2009, Pages 1065-1075

  Schmal, Hagen ^a   Mehlhorn, Alexander ^a   Stoffel, Fabian ^a   Kstler, Wolfgang ^a   Sdkamp, Norbert P ^a   Niemeyer, Philipp ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Cartilage repair; Clinical trial; Cytokine; Intraarticular; Prospective .

Indexed keywords

AGGRECAN; BASIC FIBROBLAST GROWTH FACTOR; CYTOKINE; INTERLEUKIN 1BETA; SOMATOMEDIN;

ADULT; ARTICLE; CHONDROCYTE IMPLANTATION; CHONDROPATHY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; INFLAMMATION; KNEE; KNEE SURGERY; MICROFRACTURE; PRIORITY JOURNAL;

EID: 71149104044     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.3109/14653240903219130     Document Type: Article

References (44)

1. Cicuttini F, Ding C, Wluka A, Davis S, E beling PR, J ones G. Association of cartilage defects with loss of knee cartilage in healthy, middle-age adults: a prospective study. Arthritis Rheum 2005; 52: 2033-2039 (Pubitemid 40994326)
2. Knutsen G, Drogset JO, Engebretsen L, Grontvedt T, Isaksen V, Ludvigsen TC, et al. A randomized trial com paring autologous chondrocyte implantation with micro fracture. Findings at fi ve years. J Bone Joint Surg Am 2007; 89: 2105-2112
3. Schmal H, M ehlhorn AT, Z wingmann J, M uller CA, S tark GB, Sudkamp NP. Stimulation of chondrocytes in vitro by gene transfer with plasmids coding for epidermal growth factor (hEGF) and basic fibroblast growth factor (bFGF). Cytotherapy 2005; 7: 292-300.
4. Vincent T, H ermansson M, B olton M, W ait R, S aklatvala J. Basic FGF mediates an immediate response of articular cartilage to mechanical injury. Proc Natl Acad Sci USA 2002; 99: 8259-8264
5. Wang X, M anner PA, H orner A, S hum L, T uan RS, N uckolls GH. Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage. Osteoarthritis Cartilage 2004; 12: 963-973
6. Gospodarowicz D. Purification of a fibroblast growth factor from bovine pituitary. J Biol Chem 1975; 250: 2515-2520
7. Praul CA, F ord BC, L each RM. Effect of fibroblast growth factors 1, 2, 4, 5, 6, 7, 8, 9, and 10 on avian chondrocyte proliferation. J Cell Biochem 2002; 84: 359-366
8. Schmal H, Z wingmann J, F ehrenbach M, F inkenzeller G, Stark GB, Sudkamp NP, et al. bFGF influences human articular chondrocyte differentiation. Cytotherapy 2007; 9: 184-193
9. Gaissmaier C, K oh JL, W eise K. Growth and differentiation factors for cartilage healing and repair. Injury 2008; 39 ( Suppl 1 ): S88 - 96.
10. Loeser RF, Pacione CA, C hubinskaya S. The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes. Arthritis Rheum 2003; 48: 2188-2196
11. Thenson FM, Davenport C, Butler L, Moran I, Shingleton WD, Jeffcott LB, Schofi eld PN. Effects of insulin and insulin-like growth factors I and II on the growth of equine fetal and neonatal chondrocytes. Equine Vet J 1997; 29: 441-447
12. Tsukazaki T, Usa T, Matsumoto T, Enomoto H, Ohtsuru A, Namba H, et al. Effect of transforming growth factor-beta on the insulin-like growth factor-I autocrine/paracrine axis in cultured rat articular chondrocytes. Exp Cell Res 1994; 215: 9-16.
13. Li Y, Xiang J, Duan C. Insulin-like growth factor-binding protein-3 plays an important role in regulating pharyngeal skeleton and inner ear formation and differentiation. J Biol Chem 2005; 280: 3613-3620
14. Li M, L i Y, L u L, W ang X, G ong Q, D uan C. Structural, gene expression, and functional analysis of the fugu (Takifugu rubripes) insulin-like growth factor binding protein-4 gene. Am J Physiol Regul Integr Comp Physiol 2009; 296: R558 - 66.
15. Purple CR, Untermann TG, P ichika R, Homandberg GA. Fibronectin fragments upregulate insulin-like growth factor binding proteins in chondrocytes. Osteoarthritis Cartilage 2002; 10: 734-746
16. Martin JA, M iller BA, S cherb MB, Lembke LA, B uckwalter JA. Co-localization of insulin-like growth factor binding protein 3 and fi bronectin in human articular cartilage. Osteoarthritis Cartilage 2002; 10: 556-563
17. Zhang M, Zhou Q, Liang Q, Li C, Holz JD, Tang D, e t al. IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways. Osteoarthritis Cartilage 2009; 17: 100-106
18. Verbruggen G. Chondroprotective drugs in degenerative joint diseases. Rheumatology (Oxford) 2006; 45: 129-138
19. Marks PH, D onaldson MLC. Inflammatory cytokine profi les associated with chondral damage in the anterior cruciate ligament-defi cient knee. Arthroscopy 2005; 21: 1342-1347
20. Pujol J, C hadjichristos C, L egendre F, Bauge C, B eauchef G, Andriamanalijaona R, et al. Interleukin-1 and transforming growth factor-beta 1 as crucial factors in osteoarthritic cartilage metabolism. Connect Tissue Res 2008; 49: 293-297
21. Huang K, W u LD. A ggrecanase and aggrecan degradation in osteoarthritis: a review. J Int Med Res 2008; 36: 1149-1160
22. Evaluation of cartilage injuries and repair. Brittberg M, Winalski CS. J Bone Joint Surg Am 2003;85-A Suppl 2:58-69.
23. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994; 331: 889-895
24. Gillogly SD, M yers TH, R einold MM. Treatment of full-thickness chondral defects in the knee with autologous chondrocyte implantation. J Orthop Sports Phys Ther 2006; 36: 751-764
25. Steinwachs M. New technique for cell-seeded collagen matrix-supported autologous chondrocyte transplantation. Arthroscopy 2009; 25: 208-211
26. Steinwachs MR, Guggi T, K reuz PC. M arrow stimulation techniques. Injury 2008; 39 ( Suppl 1 ): S26 - 31.
27. Kreuz PC, Erggelet C, S teinwachs MR, Krause SJ, Lahm A, Niemeyer P, et al. Is microfracture of chondral defects in the knee associated with different results in patients aged 40 years or younger? Arthroscopy 2006; 22: 1180-1186 (Pubitemid 44648675)
28. Geborek P, S axne T, H einegard D, Wollheim FA. M easurement of synovial fluid volume using albumin dilution upon intraarticular saline injection. J Rheumatol 1988; 15: 91-94
29. Wright RW. K nee injury outcomes measures. J Am Acad Orthop Surg 2009; 17: 31-39
30. Niki Y, M atsumoto H, Otani T, Yatabe T, Funayama A, Maeno S, et al. Phenotypic characteristics of joint fluid cells from patients with continuous joint effusion after total knee arthroplasty. Biomaterials 2006; 27: 1558-1565
31. Thenderson I, F rancisco R, Oakes B, Cameron J. Autologous chondrocyte implantation for treatment of focal chondral defects of the knee: a clinical, arthroscopic, MRI and histologic evaluation at 2 years. Knee 2005; 12: 209-216
32. Lohmander LS, D ahlberg L, R yd L, H einegard D. Increased levels of proteoglycan fragments in knee joint fluid after injury. Arthritis Rheum 1989; 32: 1434-1442
33. Pelletier JP, Roughley PJ, DiBattista JA, McCollum R, Martel-Pelletier J. Are cytokines involved in osteoarthritic pathophysiology? Semin Arthritis Rheum 1991; 20 ( Suppl 2 ): 12-25.
34. Outerbridge RE. The etiology of chondromalacia patellae. J Bone Joint Surg Br 1 961; 43: B752 - 7.
35. Sandell LJ, Aigner T. Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res 2001; 3: 107-113
36. Cameron ML, F u FH, Paessler HH, S chneider M, Evans CH. Synovial fluid cytokine concentrations as possible prognostic indicators in the ACL-defi cient knee. Knee Surg Sports Traumatol Arthrosc 1994; 2: 38-44.
37. Thedbom E, H auselmann HJ. Molecular aspects of pathogenesis in osteoarthritis: the role of inflammation. Cell Mol Life Sci 2002; 59: 45-53.
38. Tucci MA, T sao AK, L emos MB, H ughes JL. B iochemical and immunochemical evaluation of tissues and synovial fluid from patients undergoing total joint arthroplasty. Biomed Sci Instrum 1997; 33: 530-534
39. Neidel J, Schulze M, Lindschau J. A ssociation between degree of bone-erosion and synovial fluid-levels of tumor necrosis factor alpha in the knee-joints of patients with rheumatoid arthritis. Infl amm Res 1995; 44: 217-221
40. Noyes FR, M atthews DS, M ooar PA, Grood ES. The symptomatic anterior cruciate-defi cient knee. II. The results of rehabilitation, activity modification, and counseling on functional disability. J Bone Joint Surg Am 1983; 65: 163-174
41. Hawkins RJ, Misamore GW, M erritt TR. Followup of the acute nonoperated isolated anterior cruciate ligament tear. Am J Sports Med 1986; 14: 205-210
42. Ferretti A, C onteduca F, D e Carli A, F ontana M, M ariani PP. Osteoarthritis of the knee after ACL reconstruction. Int Orthop 1991; 15: 367-371
43. Davies LC, Blain EJ, Gilbert SJ, Caterson B, Duance VC. The potential of IGF-1 and TGFbeta1 for promoting 'adult' articular cartilage repair: an in vitro study. Tissue Eng Part A 2008; 14: 1251-1261
44. Gobbi A, B athan L. Biological approaches for cartilage repair. J Knee Surg 2009; 22: 36-44.