IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways

Osteoarthritis and Cartilage

Volumn 17, Issue 1, 2009, Pages 100-106

  Zhang, M ^a   Zhou, Q ^a   Liang, Q Q ^a   Li, C G ^a   Holz, J D ^b   Tang, D ^a   Sheu, T J ^b   Li, T F ^b   Shi, Q ^a   Wang, Y J ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Col2a1; Endplate chondrocyte; ERK MAPK; IGF 1; MMP 13; PI3K

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; COLLAGEN TYPE 2; COLLAGEN TYPE 2 ALPHA 1; COLLAGENASE 3; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOMEDIN C; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CERVICAL SPINE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; INTERVERTEBRAL DISK DEGENERATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPONDYLARTHRITIS; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CELLS, CULTURED; CERVICAL VERTEBRAE; CHONDROCYTES; COLLAGEN TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INSULIN-LIKE GROWTH FACTOR I; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 13; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 57349099369     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2008.05.007     Document Type: Article

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