Histone deacetylase and microtubules as targets for the synthesis of releasable conjugate compounds

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 22, 2009, Pages 6358-6363

  Passarella, Daniele ^a   Comi, Daniela ^a   Vanossi, Andrea ^a   Paganini, Gianfranco ^a   Colombo, Francesco ^a   Ferrante, Luca ^a   Zuco, Valentina ^b   Danieli, Bruno ^a   Zunino, Franco ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Anticancer compounds; Disulfide bond; HDAC inhibitors; Releasable conjugate compounds; Tubulin binders

Indexed keywords

CAMPHORSULFONIC ACID; CEPHALOMANNINE; COLCHICINE DERIVATIVE; GLUTATHIONE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; PACLITAXEL; PANOBINOSTAT; SULFONIC ACID DERIVATIVE; THIOCOLCHICINE; TUBULIN; UNCLASSIFIED DRUG;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL; CELL CYCLE REGULATION; CONTROLLED STUDY; CROSS REACTION; CYTOTOXICITY; DRUG CONJUGATION; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROTUBULE; MITOSIS RATE;

ACETYLATION; ANTINEOPLASTIC AGENTS; CELL CYCLE; DRUG DESIGN; GLUTATHIONE; HELA CELLS; HISTONE DEACETYLASE 2; HISTONE DEACETYLASES; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 71049188845     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.075     Document Type: Article

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