Synthesis and biological evaluation of p38α kinase-targeting dialkynylimidazoles

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 22, 2009, Pages 6293-6297

  Li, Jing ^a   Kaoud, Tamer S ^a   Laroche, Christophe ^a   Dalby, Kevin N ^a   Kerwin, Sean M ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Carbene; Diradical; Inflammation; MAPK

Indexed keywords

CYTOCHROME P450 2D6; IMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 14;

ARTICLE; BIOLOGY; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; SYNTHESIS;

ALLOSTERIC REGULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; IMIDAZOLES; MITOGEN-ACTIVATED PROTEIN KINASE 14; MODELS, CHEMICAL; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; SUBSTRATE SPECIFICITY;

EID: 71049179053     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.094     Document Type: Article

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