Protracted exposure to supraphysiological levels of corticosterone does not cause neuronal loss or damage and protects against kainic acid-induced neurotoxicity in the hippocampus of C57BL/6J mice

NeuroToxicology

Volumn 30, Issue 6, 2009, Pages 965-976

  Benkovic, Stanley A ^a   O'Callaghan, James P ^a   Miller, Diane B ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Blood brain barrier; Excitotoxicity; Glia; Neurodegeneration; Neuroprotection; Stress

Indexed keywords

ADAPTOR PROTEIN; CORTICOSTERONE; GLIAL FIBRILLARY ACIDIC PROTEIN; IBA 1 PROTEIN; IMMUNOGLOBULIN G; KAINIC ACID; PLACEBO; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARGYROPHILIA; ARTICLE; ASTROCYTOSIS; BLOOD BRAIN BARRIER; BODY WEIGHT; CELL ACTIVATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG MEGADOSE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXCITOTOXICITY; GLIOSIS; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LOW DRUG DOSE; MALE; MICROGLIA; MORTALITY; MOUSE; NERVE CELL LESION; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPHARMACOLOGY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SEIZURE; SILVER STAINING; SPLEEN WEIGHT; SUSTAINED DRUG RELEASE; THYMUS;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ANTI-INFLAMMATORY AGENTS; BLOOD-BRAIN BARRIER; CALCIUM-BINDING PROTEINS; CORTICOSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXCITATORY AMINO ACID AGONISTS; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; KAINIC ACID; MICE; MICE, INBRED C57BL; NEUROTOXICITY SYNDROMES; TIME FACTORS;

MUS; RATTUS;

EID: 71049176231     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2009.07.005     Document Type: Article

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