A simplified [11C]phosgene synthesis

Tetrahedron Letters

Volumn 51, Issue 2, 2010, Pages 313-316

  Bramoullé, Yann ^a   Roeda, Dirk ^a   Dollé, Frédéric ^a  

^a SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

Author keywords

Carbon 11; Phosgene; Radiolabelling

Indexed keywords

OXYGEN; PHOSGENE;

ARTICLE; CONTROLLED STUDY; CYCLOTRON; ISOTOPE LABELING; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; SYNTHESIS;

EID: 71049173279     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.11.011     Document Type: Article

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48. 2 can be reused an indefinite number of times. The system is thoroughly flushed with helium while the ovens are heating the quartz tubes. The helium flow is finally stopped and the helium in vessel M is replaced by chlorine gas (99.99%, Air Liquide) by way of a 3 mL syringe. Vessel M is isolated from the rest of the system by valves as is the system as a whole from the exterior.
49. 4: 14.0 min.
50. 2: 990/9.6/0.2/0.2 (v:v:v:v); flow rate: 8.0 mL/min; temperature: rt; absorbance detection at λ = 254 nm. Capacity factors: phenyl isocyanate: 6.45, N,N′-diphenylurea: 1.73, chloromethanes: 1.00.