Synthesis of 11C labeled uracil derivative for a PET tracer targeting thymidine phosphorylase

Heterocycles

Volumn 76, Issue 1, 2008, Pages 237-241

  Takahashi, Masayuki ^a   Seki, Koh Ichi ^b   Nishijima, Ken Ichi ^a   Kuge, Yuji ^b   Tamaki, Nagara ^b   Ohkura, Kazue ^a  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

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Indexed keywords

EID: 71049139937     PISSN: 03855414     EISSN: 18810942     Source Type: Journal    
DOI: 10.3987/COM-08-S(N)61     Document Type: Article

References (16)

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12. 3: C, 33.24; H, 3.14; N, 19.38. Found: C, 33.33; H, 3.09; N, 19.39.
13. 3: 247.0412. Found: 247.0421.
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15. 11C nuclear reaction on nitrogen containing hydrogen (5%) in an aluminum target. Bombardment was performed using a 20 μA beam of 18 MeV protons for 20 min.
16. 2 was bubbled with helium flow into a reaction vial containing a solution of 1a (1 mg) in t-BuOH (0.5 mL) in the presence of t-BuOK at 30 °C for 1min. The reaction mixture was subjected to reverse-phase HPLC equipped with UV monitor and radio detector: Megapak CIL C18, 25 cm × 1.0 cm i.d., 10% EtOH in water containing phosphoric acid (pH 2.32), flow rate 5.0 mL/min.